Have a personal or library account? Click to login
Application of network pharmacology, bioinformatics, computational molecular docking, and experimental validation to study the anticancer effects of oleanolic acid in oral squamous carcinoma cells
E. Gudoityte, O. Arandarcikaite, I. Mazeikiene, V. Bendokas and J. Liobikas, Ursolic and oleanolic acids: Plant metabolites with neuroprotective potential, Int. J. Mol. Sci.22(9) (2021) Article ID 4599 (15 pages); https://doi.org/10.3390/ijms22094599
T. Shan, J. Ye, J. Jia, Z. Wang, Y. Jiang, Y. Wang, Y. Wang, K. Zheng, and Z. Ren, Viral UL8 is involved in the antiviral activity of oleanolic acid against HSV-1 infection, Front. Microbiol.12 (2021) Article ID 689607 (12 pages); https://doi.org/10.3389/fmicb.2021.689607
N. Gupta, A review on recent developments in the anticancer potential of oleanolic acid and its analogs (2017-2020), Mini Rev. Med. Chem.22(4) (2022) 600–616; https://doi.org/10.2174/1389557521666210810153627
Y. Han, C. Wang, X. Li and G. Liang, Oleanolic acid reduces oxidative stress and neuronal apoptosis after experimental subarachnoid hemorrhage by regulating Nrf2/HO-1 pathway, Drug Dev. Res.83(3) (2022) 680–687; https://doi.org/10.1002/ddr.21899
E. Saberian, A. Jenča, A. Petrášová, J. Jenčová, R. A. Jahromi and R. Seiffadini, Oral cancer at a Glance, Asian Pac. J. Cancer Biol.8(4) (2023) 379–386; https://doi.org/10.31557/apjcb.2023.8.4.379-386
D. Jagadeesan, K. V. Sathasivam, N. K. Fuloria, V. Balakrishnan, G. H. Khor, M. Ravichandran, M. Solyappan, S. Fuloria, G. Gupta and G. Yadav, Comprehensive insights into oral squamous cell carcinoma: Diagnosis, pathogenesis, and therapeutic advances, Pathol. Res. Pract.261 (2024) Article ID 155489; https://doi.org/10.1016/j.prp.2024.155489
A. Capote-Moreno, P. Brabyn, M. F. Muñoz-Guerra, J. Sastre-Pérez, V. Escorial-Hernandez, F. J. Rodríguez-Campo, T. García and L. Naval-Gías, Oral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series, Int. J. Oral Maxillofac. Surg.49(12) (2020) 1525–1534; https://doi.org/10.1016/j.ijom.2020.03.009
D. Vemula, P. Jayasurya, V. Sushmitha, Y. N. Kumar and V. Bhandari, CADD, AI and ML in drug discovery: A comprehensive review, Eur. J. Pharm. Sci.181 (2023) Article ID 106324 (23 pages); https://doi.org/10.1016/j.ejps.2022.106324
M. T. Muhammed and E. Aki-Yalcin, Molecular docking: principles, advances, and its applications in drug discovery, Lett. Drug Des. Discov.21(3) (2024) 480–495; https://doi.org/10.2174/1570180819666220922103109
L. Zhao, H. Zhang, N. Li, J. Chen, H. Xu, Y. Wang and Q. Liang, Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula, J. Ethnopharmacol.309 (2023) Article ID 116306; https://doi.org/10.1016/j.jep.2023.116306
P. H. Patel, A. Jha and G. S. Chakraborthy, Role of Bioinformatics in Drug Design and Discovery, in CADD and Informatics in Drug Discovery (Part of the book series: Interdisciplinary Biotechnological Advances (IBA)), Springer Nature Singapore, Singapore 2023, pp. 1–33.
A. Daina, O. Michielin and V. Zoete, SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules, Sci. Rep.7(1) (2017) Article ID 42717 (13 pages); https://doi.org/10.1038/srep42717
A. Daina, O. Michielin and V. Zoete, SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules, Nucleic Acids Res.47(W1) (2019) W357–W364; https://doi.org/10.1093/nar/gkz382
Y. Liu, X. Yang, J. Gan, S. Chen, Z. X. Xiao and Y. Cao, CB-Dock2: Improved protein-ligand blind docking by integrating cavity detection, docking, and homologous template fitting, Nucleic Acids Res.50(W1) (2022) W159–W164; https://doi.org/10.1093/nar/gkac394
C. M. McBride, B. Levine, Y. Xia, C. Bellamacina, T. Machajewski, Z. Gao, P. Renhowe, W. Antonios-McCrea, P. Barsanti, K. Brinner and A. Costales, Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990, J. Med. Chem.57(21) (2014) 9124–9129; https://doi.org/10.1021/jm501107q
T. Hu, J. E. Yeh, L. Pinello, J. Jacob, S. Chakravarthy, G. C. Yuan, R. Chopra and D. A. Frank, Impact of the N-terminal domain of STAT3 in STAT3-dependent transcriptional activity, Mol. Cell. Biol.35(19) (2015) 3284–3300; https://doi.org/10.1128/MCB.00060-15
G. Q. Gong, B. Bilanges, B. Allsop, G. R. Masson, V. Roberton, T. Askwith, S. Oxenford, R. R. Madsen, S. E. Conduit, D. Bellini and M. Fitzek, A small-molecule PI3Kα activator for cardioprotection and neuroregeneration, Nature618(7963) (2023) 159–168; https://doi.org/10.1038/s41586-023-05972-2
J. R. López-Blanco, J. I. Aliaga, E. S. Quintana-Ortí and P. Chacón, iMODS: internal coordinates normal mode analysis server, Nucleic Acids Res.42(W1) (2014) W271–W276; https://doi.org/10.1093/nar/gku339
A. Kuriata, A. M. Gierut, T. Oleniecki, M. P. Ciemny, A. Kolinski, M. Kurcinski and S. Kmiecik, CABS-flex 2.0: A web server for fast simulations of flexibility of protein structures, Nucleic Acids Res.46(W1) (2018) W338–W343; https://doi.org/10.1093/nar/gky356
A. Maharati and M. Moghbeli, PI3K/AKT signaling pathway as a critical regulator of epithelial--mesenchymal transition in colorectal tumor cells, Cell Commun. Signal.21(1) (2023) Article ID 201 (15 pages); https://doi.org/10.1186/s12964-023-01225-x
Y. Cheng, J. Chen, Y. Shi, X. Fang and Z. Tang, MAPK signaling pathway in oral squamous cell carcinoma: biological function and targeted therapy, Cancers14(19) (2022) Article ID 4625; https://doi.org/10.3390/cancers14194625
D. B. Doroshow, S. Bhalla, M. B. Beasley, L. M. Sholl, K. M. Kerr, S. Gnjatic, I. I. Wistuba, D. L. Rimm, M. S. Tsao and F. R. Hirsch, PD-L1 as a biomarker of response to immune-checkpoint inhibitors, Nat. Rev. Clin. Oncol.18(6) (2021) 345–362; https://doi.org/10.1038/s41571-021-00473-5
M. E. Youssef, S. Cavalu, A. M. Hasan, G. Yahya, M. A. Abd-Eldayem and S. A. Saber, Role of ganetespib, an HSP90 inhibitor, in cancer therapy: from molecular mechanisms to clinical practice, Int. J. Mol. Sci.24(5) (2023) Article ID 5014; https://doi.org/10.3390/ijms24055014
M. Niu, B. Zhang, L. Li, Z. Su, W. Pu, C. Zhao, L. Wei, P. Lian, R. Lu, R. Wang and J. Wazir, Q. Gao, S. Song and H. Wang, Targeting HSP90 inhibits proliferation and induces apoptosis through AKT1/ERK pathway in lung cancer, Front. Pharmacol.12 (2022) Article ID 724192 (13 pages); https://doi.org/10.3389/fphar.2021.724192
H. A. Amissah, S. E. Combs and M. Shevtsov, Tumor dormancy and reactivation: the role of heat shock proteins, Cells13(13) (2024) Article ID 1087; https://doi.org/10.3390/cells13131087
A. Bahmei, F. Karimi, S. M. Mahini, H. Irandoost, P. Tandel, H. Niknam and G. Tamaddon, Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line, Med. Oncol.41(11) (2024) Article ID 267; https://doi.org/10.1007/s12032-024-02412-7
M. Tolomeo and A. Cascio, The multifaceted role of STAT3 in cancer and its implication for anticancer therapy, Int. J. Mol. Sci.22(2) (2021) Article ID 603; https://doi.org/10.3390/ijms22020603
Y. Hu, Z. Dong and K. Liu, Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery, J. Exp. Clin. Cancer Res. 43(1) (2024) Article ID 23 (29 pages); https://doi.org/10.1186/s13046-024-02949-5
S. Zou, Q. Tong, B. Liu, W. Huang, Y. Tian and X. Fu, Targeting STAT3 in cancer immunotherapy, Mol. Cancer19 (2020) Article ID 145 (19 pages); https://doi.org/10.1186/s12943-020-01258-7
A. Jha, M. Alam, T. Kashyap, N. Nath, A. Kumari, K. K. Pramanik, S. Nagini and R. Mishra, Crosstalk between PD-L1 and Jak2-Stat3/MAPK-AP1 signaling promotes oral cancer progression, invasion, and therapy resistance, Int. Immunopharmacol. 124(Part A) (2023) Article ID 110894; https://doi.org/10.1016/j.intimp.2023.110894
S. Sharma and P. Kumar, Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening, Neuropeptides102 (2023) Article ID 102383; https://doi.org/10.1016/j.npep.2023.102383
Y. J. Zhang and D. H. Yi, CDK1-SRC Interaction-dependent transcriptional activation of HSP90AB1 promotes antitumor immunity in hepatocellular carcinoma, J. Proteome Res.22(12) (2023) 3714–3729; https://doi.org/10.1021/acs.jproteome.3c00379
X. Sun, K. Li, M. Hase, R. Zha, Y. Feng, B.-Y. Li and H. Yokota, Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling, Theranostics12(2) (2022) 929–943; https://doi.org/10.7150/thno.66148
P. Castel, E. Toska, J. A. Engelman and M. Scaltriti, The present and future of PI3K inhibitors for cancer therapy, Nat. Cancer2(6) (2021) 587–597; https://doi.org/10.1038/s43018-021-00218-4