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Total phenolic content, flavonoid content and antioxidant potential of Petasites hybridus and related species from Croatia and considerations regarding their pharmaceutical significance Cover

Total phenolic content, flavonoid content and antioxidant potential of Petasites hybridus and related species from Croatia and considerations regarding their pharmaceutical significance

Open Access
|Jan 2025

References

  1. Ł. Kulinowski, S. V. Luca, M. Minceva and K. Skalicka-Woźniak, A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.), J. Ethnopharmacol. 293 (2022) Article ID 115263 (24 pages); https://doi.org/10.1016/j.jep.2022.115263
  2. M. Ożarowski, J. Przystanowicz and A. Adamczak, Phytochemical, pharmacological and clinical studies of Petasites hybridus (L.) P. Gaertn., B. Mey. & Scherb. A review, Herba Pol. 59(4) (2013) 108–128; https://doi.org/10.2478/hepo-2013-0028
  3. M. Avarsaji, Z. Hossaini, A. Varasteh Moradi, H. R. Jalilian and R. Z. Mehrabian, Synthesis and biological activity investigation of new oxazolopyrimidoazepine derivatives: Application of Ag/Fe3O4/TiO2/CuO@MWCNTs MNCs in the reduction of organic pollutants, Polycycl. Aromat. Comp. 43(7) (2023) 5996–6017; https://doi.org/10.1080/10406638.2022.2110903
  4. Z. Hossaini, N. Tabarsaei, S. Khandan, P. Valipour and M. Ghorchibeigi, ZnO/Ag/Fe3O4 nanoparticles supported on carbon nanotubes employing Petasites hybridus rhizome water extract: A novel organometallic nanocatalyst for the synthesis of new naphthyridines, Appl. Organomet. Chem. 35(3) (2021) Article ID e6114 (15 pages); https://doi.org/10.1002/aoc.6114
  5. J. Borlak, H.-C. Diener, J. Kleeberg-Hartmann, K. Messlinger and S. Silberstein, Petasites for migraine prevention: New data on mode of action, pharmacology and safety. A narrative review, Front. Neurol. 13 (2022) Article ID 864689 (16 pages); https://doi.org/10.3389/fneur.2022.864689
  6. X. Y. Lim, M. S. Lau, N. A. Zolkifli, U. R. Sastu Zakaria, N. S. Mohd Rahim, N. M. Lai and T. Y. C. Tan, Medicinal plants for allergic rhinitis: A systematic review and meta-analysis, PLoS One 19(4) (2024) Article ID e0297839 (32 pages); https://doi.org/10.1371/journal.pone.0297839
  7. K. Forsch, V. Schöning, G. M. Assmann, C. Moser, B. Siewert, V. Butterweck and J. Drewe, In vitro hepatotoxicity of Petasites hybridus extract (Ze 339) depends on the concentration, the cytochrome activity of the cell system, and the species used, Phytother. Res. 34(1) (2020) 184–192; https://doi.org/10.1002/ptr.6516
  8. S. Park, J. Lim, K. T. Lee, M. S. Oh and D. S. Jang, Single and repeated oral dose toxicity and genotoxicity of the leaves of butterbur, Foods 10(8) (2021) Article ID 1963 (13 pages); https://doi.org/10.3390/foods10081963
  9. E. Wildi, T. Langer, W. Schaffner and K. Berger Büter, Quantitative analysis of petasin and pyrrolizidine alkaloids in leaves and rhizomes of in situ grown Petasites hybridus plants, Planta Med. 64(3) (1998) 264–267; https://doi.org/10.1055/s-2006-957422
  10. R. Chizzola, B. Ozelsberger and T. Langer, Variability in chemical constituents in Petasites hybridus from Austria, Biochem. Syst. Ecol. 28(5) (2000) 421–432; https://doi.org/10.1016/S0305-1978(99)00077-0
  11. M. Friščić, I. Jerković, Z. Marijanović, S. Dragović, K. Hazler Pilepić and Ž. Maleš, Essential oil composition of different plant parts from Croatian Petasites albus (L.) Gaertn. and Petasites hybridus (L.) G. Gaertn., B. Mey. & Scherb. (Asteraceae), Chem. Biodiversity 16(3) (2019) Article ID e1800531 (13 pages); https://doi.org/10.1002/cbdv.201800531
  12. M. Gündüz, Ş. Karabiyikli Çiçek and S. Topuz, Extraction and optimization of phenolic compounds from butterbur plant (Petasites hybridus) by ultrasound-assisted extraction and determination of antioxidant and antimicrobial activity of butterbur extracts, J. Appl. Res. Med. Aromat. Plants 35 (2023) Article ID 100491; https://doi.org/10.1016/j.jarmap.2023.100491
  13. M. Dal Cero, R. Saller, M. Leonti and C. S. Weckerle, Trends of medicinal plant use over the last 2000 years in Central Europe, Plants 12(1) (2023) Article ID 135 (17 pages); https://doi.org/10.3390/plants12010135
  14. M. Hiemori-Kondo, Antioxidant compounds of Petasites japonicus and their preventive effects in chronic diseases: a review, J. Clin. Biochem. Nutr. 67(1) (2020) 10–18; https://doi.org/10.3164/jcbn.20-58
  15. Native American Ethnobotany DB (2003); http://naeb.brit.org/uses/search/?string=petasites+frigidus; last access date July 7, 2024
  16. B. Šarić-Kundalić, C. Dobeš, V. Klatte-Asselmeyer and J. Saukel, Ethnobotanical study on medicinal use of wild and cultivated plants in middle, south and west Bosnia and Herzegovina, J. Ethnopharmacol. 131(1) (2010) 33–55; https://doi.org/10.1016/j.jep.2010.05.061
  17. P. Janaćković, M. Gavrilović, M. Miletić, M. Radulović, S. Kolašinac and Z. Dajić Stevanović, Small regions as key sources of traditional knowledge: a quantitative ethnobotanical survey in the central Balkans, J. Ethnobiol. Ethnomed. 18(1) (2022) Article ID 70 (68 pages); https://doi.org/10.1186/s13002-022-00566-0
  18. M. Friščić, S. Maslo, R. Garić, Ž. Maleš and K. Hazler Pilepić, Comparative analysis of specialized metabolites and antioxidant capacity in vitro of different natural populations of Globularia spp. Acta Bot. Croat. 77(1) (2018) 1–9; https://doi.org/10.1515/botcro-2017-0017
  19. I. Dominguez-López, M. Pérez and R. M. Lamuela-Raventós, Total (poly)phenol analysis by the Folin-Ciocalteu assay as an anti-inflammatory biomarker in biological samples, Crit. Rev. Food Sci. Nutr. (2023) 1–7; https://doi.org/10.1080/10408398.2023.2220031
  20. M. Pérez, I. Dominguez-López and R. M. Lamuela-Raventós, The chemistry behind the Folin-Ciocalteu method for the estimation of (poly)phenol content in food: Total phenolic intake in a Mediterranean dietary pattern, J. Agric. Food Chem. 71(46) (2023) 17543−17553; https://doi.org/10.1021/acs.jafc.3c04022
  21. E. M. Ahn, G. Asamenew, H. W. Kim, S. H. Lee, S.-M. Yoo, S.-M. Cho, Y.-S. Cha and M.-S. Kang, Anti-obesity effects of Petasites japonicus (meowi) ethanol extract on RAW 264.7 macrophages and 3T3-L1 adipocytes and its characterization of polyphenolic compounds, Nutrients 12(5) (2020) Article ID 1261 (16 pages); https://doi.org/10.3390/nu12051261
  22. R. Jaiswal, J. Kiprotich and N. Kuhnert, Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family, Phytochemistry 72(8) (2011) 781–790; https://doi.org/10.1016/j.phytochem.2011.02.027
  23. A. Pękal and K. Pyrzynska, Evaluation of aluminium complexation reaction for flavonoid content assay, Food Anal. Methods . (2014) 1776–1782; https://doi.org/10.1007/s12161-014-9814-x
  24. D. Mammen, Chemical Perspective and Drawbacks in Flavonoid Estimation Assays, in Frontiers in Natural Product Chemistry, Vol. 10 (Ed. Atta-ur-Rahman), Bentham Science Publishers Pte. Ltd, Singapore 2022, pp. 189–228.
  25. Y. Zhang, F. Guo, P. Zeng, Q. Jia, Y. Li, W. Zhu and K. Chen, [Phenolic components from Petasites tricholobus], Zhongguo Zhongyao Zazhi 37(12) (2012) 1782–1787; https://doi.org/10.4268/cjcmm20121219
  26. İ Gulcin and S. H. Alwasel, DPPH radical scavenging assay, Processes 11(8) (2023) Article ID 2248 (20 pages); https://doi.org/10.3390/pr11082248
  27. M. Platzer, S. Kiese, T. Herfellner, U. Schweiggert-Weisz, O. Miesbauer and P. Eisner, Common trends and differences in antioxidant activity analysis of phenolic substances using single electron transfer based assays, Molecules 26(5) (2021) Article ID 1244 (17 pages); https://doi.org/10.3390/molecules26051244
  28. Y. Zhong and F. Shahidi, Methods for the Assessment of Antioxidant Activity in Foods, in Handbook of Antioxidants for Food Preservation (Ed. F. Shahidi), Woodhead Publishing Ltd, Cambridge 2015, pp. 287–333.
  29. S. M. Kim, S. W. Kang, S.-J. Jeon, Y.-J. Jung, C. Y. Kim, C. H. Pan and B.-H. Um, Rapid identification and evaluation of antioxidant compounds from extracts of Petasites japonicus by hyphenated-HPLC techniques, Biomed. Chromatogr. 26(2) (2012) 199–207; https://doi.org/10.1002/bmc.1646
  30. M. Hiemori-Kondo and M. Nii, In vitro and in vivo evaluation of antioxidant activity of Petasites japonicus Maxim. flower buds extracts, Biosci. Biotechnol. Biochem. 84(3) (2020) 621–632; https://doi.org/10.1080/09168451.2019.1691913
  31. A. Jahn and M. Petersen, Fukinolic acid and cimicifugic acids: a review, Phytochem. Rev. 21 (2022) 1247–1271; https://doi.org/10.1007/s11101-021-09781-1
  32. M. Mohammadi, M. Yousefi, Z. Habibi and D. Dastan, Chemical composition and antioxidant activity of the essential oil of aerial parts of Petasites albus from Iran: a good natural source of euparin, Nat. Prod. Res. 26(4) (2012) 291–297; https://doi.org/10.1080/14786410903374819
  33. J. Y. Choi, K. T. Desta, V. V. G. Saralamma, S. J. Lee, S. J. Lee, S. M. Kim, A. Paramanantham, H. J. Lee, Y.-H. Kim, H.-C. Shin, J.-H. Shim, M. Warda, A. Hacımüftüoğlu, J. H. Jeong, S. C. Shin, G.-S. Kim and A. M. Abd El-Aty, LC–MS/MS characterization, anti-inflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus (Meowi), Biomed. Chromatogr. 31(12) (2017) Article ID e4033 (9 pages); https://doi.org/10.1002/bmc.4033
  34. T. Mihajilov-Krstev, B. Jovanović, B. Zlatković, J. Matejić, J. Vitorović, V. Cvetković, B. Ilić, Lj. Đorđević, N. Joković, D. Miladinović, T. Jakšić, N. Stanković, V. Stankov Jovanović and N. Bernstein, Phytochemistry, toxicology and therapeutic value of Petasites hybridus subsp. ochroleucus (common butterbur) from the Balkans, Plants .(6) (2020) Article ID 700 (15 pages); https://doi.org/10.3390/plants9060700
  35. M. Friščić, M. Štibrić Baglama, M. Milović, K. Hazler Pilepić and Ž. Maleš, Content of bioactive constituents and antioxidant potential of Galium L. species, Croat. Chem. Acta 91(3) (2018) 411–417; https://doi.org/10.5562/cca3379
  36. T. Marić, M. Friščić, Z. Marijanović, Ž. Maleš and I. Jerković, Comparison of volatile organic compounds of Sideritis romana L. and Sideritis montana L. from Croatia, Molecules 26(19) (2021) 5968 (20 pages); https://doi.org/10.3390/molecules26195968
  37. T. Nikolić. Flora Croatica – vaskularna flora Republike Hrvatske, Vol. 2, Alfa, Zagreb 2020, pp. 551–552.
  38. T. Nikolić (ed.) (2005-onwards): Flora Croatica Database, University of Zagreb, Faculty of Science, Department of Botany and Botanical Garden, Zagreb; http://hirc.botanic.hr/fcd; last access date July 7, 2024
  39. M. Miliša, A. Belančić, R. Matoničkin Kepčija, M. Sertić-Perić, A. Ostojić and I. Habdija, Calcite deposition in karst waters is promoted by leaf litter breakdown and vice versa, Ann. Limnol. – Int. J. Lim. 46 (2010) 225–232; https://doi.org/10.1051/limn/2010023
  40. N. S. Alsaiari, F. M. Alzahrani, A. Amari, H. Osman, H. N. Harharah, N. Elboughdiri and M. A. Tahoon, Plant and microbial approaches as green methods for the synthesis of nanomaterials: Synthesis, applications, and future perspectives, Molecules 28(1) (2023) Article ID 463 (38 pages); https://doi.org/10.3390/molecules28010463
  41. A. I. Osman, Y. Zhang, M. Farghali, A. K. Rashwan, A. S. Eltaweil, E. M. Abd El-Monaem, I. M. A. Mohamed, M. M. Badr, I. Ihara, D. W. Rooney and P.-S. Yap, Synthesis of green nanoparticles for energy, biomedical, environmental, agricultural, and food applications: A review, Environ. Chem. Lett. 22 (2024) 841–887; https://doi.org/10.1007/s10311-023-01682-3
  42. M. A. Khalilzadeh, S. Tajik, H. Beitollahi and R. A. Venditti, Green synthesis of magnetic nano-composite with iron oxide deposited on cellulose nanocrystals with copper (Fe3O4@CNC/Cu): Investigation of catalytic activity for the development of a venlafaxine electrochemical sensor, Ind. Eng. Chem. Res. 59(10) (2020) 4219−4228; https://doi.org/10.1021/acs.iecr.9b06214
  43. B. Debrunner and B. Meier, Petasites hybridus: A tool for interdisciplinary research in phytotherapy, Pharm. Acta Helv. 72(6) (1998) 359−380; https://doi.org/10.1016/S0031-6865(97)00027-7
  44. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Butterbur, updated 2019 Feb 18; https://www.ncbi.nlm.nih.gov/books/NBK547997/; last access date July 7, 2024
  45. S. Ying, Z. Guan, P. C. Ofoegbu, P. Clubb, C. Rico, F. He and J. Hong, Green synthesis of nanoparticles: Current developments and limitations, Environ. Technol. Innov. 26 (2022) 102336 (20 pages); https://doi.org/10.1016/j.eti.2022.102336
  46. M. Blosa, J. Uricher, S. Nebel, C. Zahner, V. Butterweck and J. Drewe, Treatment of early allergic and late inflammatory symptoms of allergic rhinitis with Petasites hybridus leaf extract (Ze 339): Results of a noninterventional observational study in Switzerland, Pharmaceuticals 14(3) (2021) Article ID 180 (13 pages); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996175/
  47. J. Melzer, E. Schrader, A. Brattström, R. Schellenberg and R. Saller, Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: Randomized, placebo-controlled pharmaco-clinical trial, Phytother. Res. 23(9) (2009) 1303–1308; https://doi.org/10.1002/ptr.2771
  48. S. Meier, M. Haschke, C. Zahner, E. Kruttschnitt, J. Drewe, E. Liakoni, F. Hammann and J. Gaab, Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men – An explorative randomized placebo-controlled double-blind study, Phytomedicine 39 (2018) 85–92; https://doi.org/10.1016/j.phymed.2017.12.005
  49. U. Kodjadjiku, B. Nägele, C. Halbsguth and V. Butterweck, Extract matrix composition does not affect in vitro leukotriene inhibitory effects of the Petasites hybridus extract Ze 339, Fitoterapia 153 (2021) Article ID 104986 (6 pages); https://doi.org/10.1016/j.fitote.2021.104986
  50. P. A. Uwineza and A. Waśkiewicz, Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials, Molecules 25(17) (2020) Article ID 3847 (23 pages); https://doi.org/10.3390/molecules25173847
  51. L. López-Hortas, P. Rodríguez, B. Díaz-Reinoso, M. C. Gaspar, H. C. de Sousa, M. E. M. Braga and H. Domínguez, Supercritical fluid extraction as a suitable technology to recover bioactive compounds from flowers, J. Supercrit. Fluids 188 (2022) Article ID 105652 (21 pages); https://doi.org/10.1016/j.supflu.2022.105652
  52. L. Song, P. Liu, Y. Yan, Y. Huang, B. Bai, X. Hou and L. Zhang, Supercritical CO2 fluid extraction of flavonoid compounds from Xinjiang jujube (Ziziphus jujuba Mill.) leaves and associated biological activities and flavonoid compositions, Ind. Crop. Prod. 139 (2019) Article ID 111508 (8 pages); https://doi.org/10.1016/j.indcrop.2019.111508
  53. N. B. Rathod, N. Elabed, S. Punia, F. Ozogul, S.-K. Kim and J. M. Rocha, Recent developments in polyphenol applications on human health: A review with current knowledge, Plants 12(6) (2023) Article ID 1217 (30 pages); https://doi.org/10.3390/plants12061217
  54. N. Kim, J. G. Choi, S. Park, J. K. Lee and M. S. Oh, Butterbur leaves attenuate memory impairment and neuronal cell damage in amyloid beta-induced Alzheimer’s disease models, Int. J. Mol. Sci. 19(6) (2018) Article ID 1644 (15 pages); https://doi.org/10.3390/ijms19061644
DOI: https://doi.org/10.2478/acph-2024-0032 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 709 - 723
Accepted on: Aug 17, 2024
|
Published on: Jan 9, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2025 Maja Friščić, Katarina Vilić, Sandra Jurić, Kroata Hazler Pilepić, Željan Maleš, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.