References
- Y. Lin, Y. Xu and Z. Zhang, Sepsis-induced myocardial dysfunction (SIMD): the pathophysiological mechanisms and therapeutic strategies targeting mitochondria, Inflammation 43(4) (2016) 1184–1200; https://doi.org/10.1007/s10753-020-01233-w
- J. C. Marshall and A. al Naqbi, Principles of source control in the management of sepsis, Crit. Care Clin. 25(4) (2019) 753–768; https://doi.org/10.1016/j.ccc.2009.08.001
- E. R. Johnson and M. A. Matthay, Acute lung injury: Epidemiology, pathogenesis, and treatment, J. Aerosol Med. Pulm. Drug Deliv. 23(4) 2010 243–252; https://doi.org/10.1089/jamp.2009.0775
- Y. Chen, H. Tong, Z. Pan, D. Jiang, X. Zhang, J. Qiu, L. Su and M. Zhang, Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and pro-inflammatory damage in rats with heat stroke, Exp. Ther. Med. 13 (2017) 3408–3416; https://doi.org/10.3892/etm.2017.4444
- S. Saharan, R. Lodha and S. K. Kabra, Management of acute lung injury/ARDS, Indian J. Pediatr. 77(11) (2010) 1296–1302; https://doi.org/10.1007/s12098-010-0169-z
- J. C. Rudkowski, E. Barreiro, R. Harfouche, P. Goldberg, O. Kishta, P. D’Orleans-Juste, J. Labonte, O. Lesur and S. N. A. Hussain, Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis, Am. J. Physiol. Lung Cell. Mol. Physiol. 286 (2004) L793–L800; https://doi.org/10.1152/ajplung.00266.2003
- A. Ansari, A. Ali, M. Asif and Shamsuzzaman, Review: biologically active pyrazole derivatives, New J. Chem. 41 (2017) 16–41; https://doi.org/10.1039/c6nj03181a
- J. Marino, Celecoxib, in The Essence Analgesia and Analgesics – Section 4 NSAIDS – Chapter 56, (Eds. R. S. Sinatra, J. S. Jahr and J. M. Watkins-Pitchford), Cambridge University Press, Cambridge 2010, pp. 238–242; https://doi.org/10.1017/CBO9780511841378.056
- G. Steinbach, P. M. Lynch, R. K. S. Phillips, M. H. Wallace, E. Hawk, G. B. Gordon, N. Wakabayashi, B. Saunders, Y. Shen, T. Fujimura, L. K. Su, B. Levin, L. Godio, S. Patterson, M. A. Rodriguez-Bigas, S. L. Jester, K. L. King, M. Schumacher, J. Abbruzzese, R. N. DuBois, W. N. Hittelman, S. Zimmerman, J. W. Sherman and G. Kelloff, The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis, N. Engl. J. Med. 342 (2000) 1946–1952; https://doi.org/10.1056/NEJM200006293422603
- M. Mantzanidou, E. Pontiki and D. Hadjipavlou-Litina, Pyrazoles and pyrazolines as anti-inflammatory agents, Molecules 26(11) (2021) Article ID 3439 (18 pages); https://doi.org/10.3390/molecules26113439
- A. Rahman and F. Fazal, Blocking NF-kB: An inflammatory issue, Proc. Am. Thorac. Soc. 8(6) (2011) 497–503; https://doi.org/10.1513/pats.201101-009MW
- E. Abraham, Nuclear factor-κB and its role in sepsis-associated organ failure, J. Infect. Dis. 187 (2003) S364–S369; https://doi.org/10.1086/374750
- C. Bhan, P. Dipankar, P. Chakraborty and P. P. Sarangi, Role of cellular events in the pathophysiology of sepsis, Inflamm. Res. 65(11) (2016) 853–868; https://doi.org/10.1007/s00011-016-0970-x
- L. Bird, Inflammation: Hope for sepsis treatment, Nat. Rev. Drug Discov. 9 (2010) 516–517; https://doi.org/10.1038/nrd3212
- R. Goel, V. Luxami and K. Paul, Recent advances in development of imidazo[1,2-a]pyrazines: Synthesis, reactivity and their biological applications, Org. Biomol. Chem. 13(12) (2015) 3525–3555; https://doi.org/10.1039/c4ob01380h
- S. Hemasrilatha, K. Sruthi, A. Manjula, V. Harinadha Babu and B. Vittal Rao, Synthesis and anti-inflammatory activity of imidazo[1,2-a]pyridinyl/pyrazinyl benzamides and acetamides, Indian J. Chem. – Sect. B Org. Med. Chem. 51 (2012) 981–987.
- A. Özdemir, G. Turan-Zitouni, Z. A. Kaplancikli and Y. Tunali, Synthesis and biological activities of new hydrazide derivatives, J. Enzyme Inhib. Med. Chem. 24 (2009) 825–831; https://doi.org/10.1080/14756360802399712
- S. A. H. El-Feky, Z. K. Abd El-Samii, N. A. Osman, J. Lashine, M. A. Kamel and H. K. Thabet, Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II, Bioorg. Chem. 58 (2015) 104–116; https://doi.org/10.1016/j.bioorg.2014.12.003
- J. K. Srivastava, G. G. Pillai, H. R. Bhat, A. Verma and U. P. Singh, Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating epidermal growth factor receptor tyrosine kinase, Sci. Rep. 7 (2017) Article ID 5851 (17 pages); https://doi.org/10.1038/s41598-017-05934-5
- J. K. Srivastava, N. T. Awatade, H. R. Bhat, A. Kmit, K. Mendes, M. Ramos, M. D. Amaral and U. P. Singh, Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity, RSC Adv. 5(108) (2015) 88710–88718; https://doi.org/10.1039/c5ra09250g
- A. Masih, A. K. Agnihotri, J. K. Srivastava, N. Pandey, H. R. Bhat and U. P. Singh, Discovery of novel pyrazole derivatives as a potent anti-inflammatory agent in RAW264.7 cells via inhibition of NF-ĸB for possible benefit against SARS-CoV-2, J. Biochem. Mol. Toxicol. 35 (2021) e22656; https://doi.org/10.1002/jbt.22656
- Organisation for Economic Co-operation and Development, OECD Guidelines, OECD 423. Acute Oral Toxicity, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris 2002; https://www.oecd-ilibrary.org/environment/test-no-423-acute-oral-toxicity-acute-toxic-class-method_9789264071001-en
- L. Dejager, I. Pinheiro, E. Dejonckheere and C. Libert, Cecal ligation and puncture: The gold standard model for polymicrobial sepsis?, Trends Microbiol. 19(4) (2011) 198–208; https://doi.org/10.1016/j.tim.2011.01.001
- L. A. Huppert, M. A. Matthay and L. B. Ware, Pathogenesis of acute respiratory distress syndrome, Semin. Respir. Crit. Care Med. 40 (2019) 31–39; https://doi.org/10.1055/s-0039-1683996
- A. J. Walkey, R. Summer, V. Ho and P. Alkana, Acute respiratory distress syndrome: Epidemiology and management approaches, Clin. Epidemiol. 4(1) (2012) 159–169; https://doi.org/10.2147/CLEP.S28800
- Q. Kong, X. Wu, Z. Qiu, Q. Huang, Z. Xia and X. Song, Protective effect of dexmedetomidine on acute lung injury via the upregulation of tumour necrosis factor-α-induced protein-8-like 2 in septic mice, Inflammation 43 (2020) 833–846; https://doi.org/10.1007/s10753-019-01169-w
- M. T. P. de Oliveira, D. de S. Coutinho, É. T. de Souza, S. S. Guterres, A. R. Pohlmann, P. M. R. Silva, M. A. Martins and A. Bernardi, Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways, Int. J. Nanomed. 14 (2019) 5215–5228; https://doi.org/10.2147/IJN.S200666
- B. B. Davis, Y.-H. Shen, D. J. Tancredi, V. Flores, R. P. Davis and K. E. Pinkerton, Leukocytes are recruited through the bronchial circulation to the lung in a spontaneously hypertensive rat model of COPD, PLoS ONE 7(3) (2012) e33304; https://doi.org/10.1371/journal.pone.0033304
- J. Rebetz, J. W. Semple and R. Kapur, The pathogenic involvement of neutrophils in acute respiratory distress syndrome and transfusion-related acute lung injury, Transfus. Med. Hemother. 45(5) (2018) 290–298; https://doi.org/10.1159/000492950
- C. W. Chow, M. T. H. Abreu, T. Suzuki and G. P. Downey, Oxidative stress and acute lung injury, Am. J. Respir. Cell Mol. Biol. 29(4) (2003) 427–431; https://doi.org/10.1165/rcmb.F278
- H. S. Park, S. R. Kim and Y. C. Lee, Impact of oxidative stress on lung diseases, Respirology 14(1) (2009) 27–38; https://doi.org/10.1111/j.1440-1843.2008.01447.x
- V. M. Victor, M. Rocha and M. De La Fuente, Immune cells: Free radicals and antioxidants in sepsis, Int. Immunopharmacol. 4(3) (2004) 327–347; https://doi.org/10.1016/j.intimp.2004.01.020
- D. Bin Yim, D. E. Lee, Y. So, C. Choi, W. Son, K. Jang, C. S. Yang and J. H. Kim, Sustainable nanosheet antioxidants for sepsis therapy via scavenging intracellular reactive oxygen and nitrogen species, ACS Nano 14 (2020) 10324–10336; https://doi.org/10.1021/acsnano.0c03807
- H. F. Galley, Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis, Crit. Care 14(4) (2010) Article ID 230 (9 pages); https://doi.org/10.1186/cc9098
- M. Rocha, R. Herance, S. Rovira, A. Hernández-Mijares and V. M. Victor, Mitochondrial dysfunction and antioxidant therapy in sepsis, Infect. Disord. - Drug Targets 12(2) (2012) 161–178; https://doi.org/10.2174/187152612800100189
- A. Strzepa, K. A. Pritchard and B. N. Dittel, Myeloperoxidase: A new player in autoimmunity, Cell. Immunol. 317 (2017) 1–8; https://doi.org/10.1016/j.cellimm.2017.05.002
- D. R. Janeiro, Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury, Free Radic. Biol. Med. 9(6) (1990) 515–540; https://doi.org/10.1016/0891-5849(90)90131-2
- J. Sha, B. Sui, X. Su, Q. Meng and C. Zhang, Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy, Mol. Med. Rep. 16 (2017) 7715–7723; https://doi.org/10.3892/mmr.2017.7522
- D. K. Gupta, J. M. Palma and F. J. Corpas (Eds.), Reactive Oxygen Species and Oxidative Damage in Plants Under Stress, Springer, Cham 2015.
- R. B. Goodman, J. Pugin, J. S. Lee and M. A. Matthay, Cytokine-mediated inflammation in acute lung injury, Cytokine Growth Factor Rev. 14(6) (2003) 523–535; https://doi.org/10.1016/S1359-6101(03)00059-5
- U. P. Singh, J. K. Srivastava and H. R. Bhat, Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/mTOR inhibitor against non-small cell lung cancer (NSCLC), Ann. Oncol. 27(Suppl. 9) (2016) 161P - Abstracts ix50; https://doi.org/10.1016/S0923-7534(21)00319-7
- Q, Kong, X. Wu, Z. Qiu, Q. Huang, Z. Xia and X. Song, Protective effect of dexmedetomidine on acute lung injury via the upregulation of tumour necrosis factor-α-induced protein-8-like 2 in septic mice, Inflammation 43 (2020) 833–846; https://doi.org/10.1007/s10753-019-01169-w
- Y. Chen, H. Tong, Z. Pan, D. Jiang, X. Zhang, J. Qiu, L. Su and M. Zhang, Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and pro-inflammatory damage in rats with heat stroke, Exp. Ther. Med. 13 (2017) 3408–3416; https://doi.org/10.3892/etm.2017.4444
- D. Jiang, J. Liang, J. Fan, S. Yu, S. Chen, Y. Luo, G. D. Prestwich, M. M. Mascarenhas, H. G. Garg, D. A. Quinn, R. J. Homer, D. R. Goldstein, R. Bucala, P. J. Lee, R. Medzhitov and P. W. Noble, Regulation of lung injury and repair by toll-like receptors and hyaluronan, Nat. Med. 11 (2005) 1173–1179; https://doi.org/10.1038/nm1315