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Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells Cover

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Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Acta Pharmaceutica

Volume 72 (2022): Issue 3 (September 2022)

By: Yoo Kyung Hong, Sungkwan An, Yun Hee Lee, Seung Ah Yang, Yoo Kyung Yoon, Joonil Lee, Gwasoo Lee, Myung Jun Chung and Seunghee Bae

Open Access

|Apr 2022

Abstract

In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis. Further exa mination of potential anti-pigmentation effects revealed that the B. lactis-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes.

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Articles in this issue

DOI: https://doi.org/10.2478/acph-2022-0027 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 359 - 374

Accepted on: Dec 16, 2021

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Published on: Apr 13, 2022

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

conditioned media,

anti-pigmentation

Related subjects:

Pharmacy, other

© 2022 Yoo Kyung Hong, Sungkwan An, Yun Hee Lee, Seung Ah Yang, Yoo Kyung Yoon, Joonil Lee, Gwasoo Lee, Myung Jun Chung, Seunghee Bae, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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