Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

Monton, Chaowalit; Chuanchom, Panupong; Popanit, Puwadon; Settharaksa, Sukanya; Pathompak, Pathamaporn

doi:10.2478/acph-2021-0025

Abstract

The aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.

References

1. Khamin Chan, in Thai Herbal Pharmacopoeia 2017, Department of Medical Sciences, the Agricultural Co-operative Federation of Thailand, Bangkok 2017, pp. 135–142.
Search in Google Scholar Back to article
2. R. Agarwal, S. K. Gupta, S. Srivastava, P. Agarwal and S. S. Agrawal, Therapeutic potential of Curcuma longa, the golden spice of India, in drug discovery for ophthalmic diseases, Expert Opin. Drug Discov.4 (2009) 147–158; https://doi.org/10.1517/1354377080266811710.1517/1354377080266811723480513
Search in Google Scholar Back to article
3. V. Soleimani, A. Sahebkar and H. Hosseinzadeh, Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review, Phytother Res. 32 (2018) 985–995; https://doi.org/10.1002/ptr.605410.1002/ptr.605429480523
Search in Google Scholar Back to article
4. A. Sikha, A. Harini and L. Hegde Prakash, Pharmacological activities of wild turmeric (Curcuma aromatica Salisb): a review, J. Pharmacogn. Phytochem.3 (2015) 1–4.
Search in Google Scholar Back to article
5. E. Mudge, M. Chan, S. Venkataraman and P. N. Brown, Curcuminoids in turmeric roots and supplements: Method optimization and validation, Food Anal. Meth. 9 (2016) 1428–1435; https://doi.org/10.1007/s12161-015-0326-010.1007/s12161-015-0326-0
Search in Google Scholar Back to article
6. T. Masuda, K. Hidaka, A. Shinohara, T. Maekawa, Y. Takeda and H. Yamaguchi, Chemical studies on antioxidant mechanism of curcuminoid: Analysis of radical reaction products from curcumin, J. Agric. Food Chem.47 (1999) 71–77; https://doi.org/10.1021/jf980534810.1021/jf980534810563852
Search in Google Scholar Back to article
7. T. Masuda, T. Maekawa, K. Hidaka, H. Bando, Y. Takeda and H. Yamaguchi, Chemical studies on antioxidant mechanism of curcumin: Analysis of oxidative coupling products from curcumin and linoleate, J. Agric. Food Chem.49 (2001) 2539–2547; https://doi.org/10.1021/jf001442x10.1021/jf001442x11368633
Search in Google Scholar Back to article
8. K. I. Priyadarsini, The chemistry of curcumin: from extraction to therapeutic agent, Molecules19 (2014) 20091–20112; https://doi.org/10.3390/molecules19122009110.3390/molecules191220091627078925470276
Search in Google Scholar Back to article
9. V. P. Menon and A. R. Sudheer, Antioxidant and anti-inflammatory properties of curcumin, Adv. Exp. Med. Biol.595 (2007) 105–125; https://doi.org/10.1007/978-0-387-46401-5_310.1007/978-0-387-46401-5_317569207
Search in Google Scholar Back to article
10. T. Ak and I. Gulcin, Antioxidant and radical scavenging properties of curcumin, Chem. Biol. Interact.174 (2008) 27–37; https://doi.org/10.1016/j.cbi.2008.05.00310.1016/j.cbi.2008.05.00318547552
Search in Google Scholar Back to article
11. G. K. Jayaprakasha, L. Jaganmohan Rao and K. K. Sakariah, Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin, Food Chem.98 (2006) 720–724; https://doi.org/10.1016/j.foodchem.2005.06.03710.1016/j.foodchem.2005.06.037
Search in Google Scholar Back to article
12. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1), Current Step 4 version, ICH, Geneva, November 2005; https://database.ich.org/sites/default/files/Q2%28R1%29%20Guideline.pdf; last access date May 2, 2019
Search in Google Scholar Back to article
13. C. Monton, C. Luprasong and L. Charoenchai, Convection combined microwave drying affect quality of volatile oil compositions and quantity of curcuminoids of turmeric raw material, Rev. Bras. Farmacogn.29 (2019) 434–440; https://doi.org/10.1016/j.bjp.2019.04.00610.1016/j.bjp.2019.04.006
Search in Google Scholar Back to article
14. G. K. Jayaprakasha, L. Jagan Mohan Rao and K. K. Sakariah, Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, J. Agric. Food Chem.50 (2002) 3668–3672; https://doi.org/10.1021/jf025506a10.1021/jf025506a12059141
Search in Google Scholar Back to article
15. I. Ali, A. Haque and K. Saleem, Separation and identification of curcuminoids in turmeric powder by HPLC using phenyl column, Anal. Meth.6 (2014) 2526–2536; https://doi.org/10.1039/c3ay41987h10.1039/C3AY41987H
Search in Google Scholar Back to article
16. J. F. Osorio-Tobón, P. I. Carvalho, G. F. Barbero, G. C. Nogueira, M. A. Rostagno and M. A. Meireles, Fast analysis of curcuminoids from turmeric (Curcuma longa L.) by high-performance liquid chromatography using a fused-core column, Food Chem.200 (2016) 167–174; https://doi.org/10.1016/j.food-chem.2016.01.02110.1016/j.foodchem.2016.01.021
Search in Google Scholar Back to article
17. C. Monton, L. Charoenchai, J. Suksaeree and L. Sueree, Quantitation of curcuminoid contents, dissolution profile, and volatile oil content of turmeric capsules produced at some secondary government hospitals, J. Food Drug Anal.24 (2016) 493–499; https://doi.org/10.1016/j.jfda.2016.01.00710.1016/j.jfda.2016.01.00728911554
Search in Google Scholar Back to article
18. S. Paramapojn and W. Gritsanapan, Variation of curcuminoids in ethanolic extract of Curcuma zedoaria rhizomes in Thailand by HPLC, Planta Med.73 (2007) P_227; https://doi.org/10.1055/s-2007-98700810.1055/s-2007-987008
Search in Google Scholar Back to article
19. S. Paramapojn and W. Gritsanapan, Quantitative Analysis of Curcuminoids in Curcuma zedoaria Rhizomes in Thailand by HPLC Method, in International Workshop on Medicinal and Aromatic Plants (Eds. N. Chomchalow and V. Chantrasmi), Vol. 1, Chiang Mai (Thailand) 2008; ISHS Acta Hortic.786 (2008) 169–174; https://doi.org/10.17660/ActaHortic.2008.786.1810.17660/ActaHortic.2008.786.18
Search in Google Scholar Back to article
20. T. Morishita, H. Yamaguchi, K. Degi, A. Shimizu and H. Nakagawa, Comparison of curcumin contents and antioxidative activities among turmeric species cultivated in Kanto area, Jpn. J. Crop Sci.82 (2013) 56–62; https://doi.org/10.1626/jcs.82.5610.1626/jcs.82.56
Search in Google Scholar Back to article
21. C. Tohda, N. Nakayama, F. Hatanaka and K. Komatsu, Comparison of anti-inflammatory activities of six Curcuma rhizomes: A possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract, Evid. Based Complement. Alternat. Med.3 (2006) 255–260; https://doi.org/10.1093/ecam/nel00810.1093/ecam/nel008147593316786056
Search in Google Scholar Back to article
22. J. Zhang, S. Jinnai, R. Ikeda, M. Wada, S. Hayashida and K. Nakashima, A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products, Anal. Sci.25 (2009) 385–388; https://doi.org/10.2116/analsci.25.38510.2116/analsci.25.38519276595
Search in Google Scholar Back to article
23. J. Lee, Y. Jung, J. H. Shin, H. K. Kim, B. C. Moon, D. H. Ryu and G. S. Hwang, Secondary metabolite profiling of Curcuma species grown at different locations using GC/TOF and UPLC/Q-TOF MS, Molecules19 (2014) 9535–9551; https://doi.org/10.3390/molecules1907953510.3390/molecules19079535627082525000465
Search in Google Scholar Back to article
24. F. Abas, L. S. Hui, S. Ahmad, J. Stanslas, D. A. Israf, K. Shaari and N. H. Lajis, Biological evaluation of curcumin and related diarylheptanoids, Z. Naturforsch. C61 (2006) 625–631; https://doi.org/10.1515/znc-2006-9-100210.1515/znc-2006-9-100217137104
Search in Google Scholar Back to article
25. S. K. Borra, P. Gurumurthy, J. Mahendra, K. M. Jayamathi, C. N. Cherian and R. Chand, Antioxidant and free radical scavenging activity of curcumin determined by using different in vitro and ex vivo models, J. Med. Plants Res.7 (2013) 2680–2690; https://doi.org/10.5897/JMPR2013.5094
Search in Google Scholar Back to article
26. M. Sökmen and M. Akram Khan, The antioxidant activity of some curcuminoids and chalcones, Inflammopharmacology24 (2016) 81–86; https://doi.org/10.1007/s10787-016-0264-510.1007/s10787-016-0264-5488344827188988
Search in Google Scholar Back to article
27. F. O. S. Camatari, K. H. Lopes, B. I. Valentim, J. A. Xavier, J. G. da Costa, A. E. G. Santana and M. O. F. Goulart, Antioxidant potential of flours from cereals, tubers, beans and seeds chemical profile of Curcuma longa flour, J. Nutr. Food Sci.6 (2016) 1000483; https://doi.org/10.4172/2155-9600.100048310.4172/2155-9600.1000483
Search in Google Scholar Back to article
28. S. Zaeoung, A. Plubrukarn and N. Keawpradub, Cytotoxic and free radical scavenging activities of Zingiberaceous rhizomes, Songklanakarin J. Sci. Technol.27 (2005) 799–812.
Search in Google Scholar Back to article
29. E. M. Tanvir, M. S. Hossen, M. F. Hossain, R. Afroz, S. H. Gan, M. I. Khalil and N. Karim, Antioxidant properties of popular turmeric (Curcuma longa) varieties from Bangladesh, J. Food Qual.2017 (2017) 8471785; https://doi.org/10.1155/2017/847178510.1155/2017/8471785
Search in Google Scholar Back to article
30. E. Souria, G. Amin, H. Farsam, H. Jalalizadeh and S. Barezi, Screening of thirteen medicinal plant extracts for antioxidant activity, Iran. J. Pharm. Res.7 (2008) 149–154; https://doi.org/10.22037/IJPR.2010.758
Search in Google Scholar Back to article
31. G. Nahak and R. K. Sahu, Evaluation of antioxidant activity in ethanolic extracts of five curcuma species, Int. Res. J. Pharm.2 (2011) 243–248.
Search in Google Scholar Back to article
32. A. R. Srividya, P. Dhanabal, Parthkumar Bavadia, V. J. Vishnuvarthan and M. N. S. Kumar, Anti-oxidant and antidiabetic activity of Curcuma aromatica, Int. J. Res. Ayurveda Pharm.3 (2012) 401–405.
Search in Google Scholar Back to article
33. S. Duangjit, L. M. Mehr, M. Kumpugdee-Vollrath and T. Ngawhirunpat, Role of simplex lattice statistical design in the formulation and optimization of microemulsions for transdermal delivery, Biol. Pharm. Bull.37 (2014) 1948–1957; https://doi.org/10.1248/bpb.b14-0054910.1248/bpb.b14-0054925590086
Search in Google Scholar Back to article
34. S. Duangjit, Y. Obata, H. Sano, S. Kikuchi, Y. Onuki, P. Opanasopit, T. Ngawhirunpat, Y. Maitani and K. Takayama, Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization, Biol. Pharm. Bull.35 (2012) 1720–1728; https://doi.org/10.1248/bpb.b12-0034310.1248/bpb.b12-0034323037161
Search in Google Scholar Back to article
35. M. A. Bezerra, R. E. Santelli, E. P. Oliveira, L. S. Villar and L. A. Escaleira, Response surface methodology (RSM) as a tool for optimization in analytical chemistry, Talanta76 (2008) 965–977; https://doi.org/10.1016/j.talanta.2008.05.01910.1016/j.talanta.2008.05.01918761143
Search in Google Scholar Back to article

Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

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