References
- 1. R. Sharma and Y. Padwad, In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors, Nutrition65 (2019) 33–38; https://doi.org/10.1016/j.nut.2019.01.02010.1016/j.nut.2019.01.02031029919
- 2. T. Zuliani, V. Denis, E. Noblesse, S. Schnebert, P. Andre, M. Dumas and M. H. Ratinaud, Hydrogen peroxide-induced cell death in normal human keratinocytes is differentiation dependent, Free Radic. Biol. Med.38 (2005) 307–316; https://doi.org/10.1016/j.freeradbiomed.2004.09.02110.1016/j.freeradbiomed.2004.09.02115629860
- 3. P. Davalli, T. Mitic, A. Caporali, A. Lauriola and D. D’Arca, ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases, Oxid. Med. Cell. Long.2016 (2016) 3565127; https://doi.org/10.1155/2016/356512710.1155/2016/3565127487748227247702
- 4. B. W. Darbro, G. B. Schneider and A. J. Klingelhutz, Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes, J. Invest. Dermatol.125 (2005) 499–509; https://doi.org/10.1111/j.0022-202X.2005.23844.x10.1111/j.0022-202X.2005.23844.x202085016117791
- 5. M. Sasaki, H. Kajiya, S. Ozeki, K. Okabe and T. Ikebe, Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.), Biochem. Biophys. Res. Commun.452 (2014) 622–628; https://doi.org/10.1016/j.bbrc.2014.08.12310.1016/j.bbrc.2014.08.12325181340
- 6. N. Alépée, M. H. Grandidier and J. Cotovio, Sub-categorisation of skin corrosive chemicals by the EpiSkin™ reconstructed human epidermis skin corrosion test method according to UN GHS: Revision of OECD Test Guideline 431, Toxicol. In Vitro28 (2014) 131–145; https://doi.org/10.1016/j.tiv.2013.10.01610.1016/j.tiv.2013.10.01624211528
- 7. C. Gerecke, A. Edlich, M. Giulbudagian, F. Schumacher, N. Zhang, A. Said, G. Yealland, S. B. Lohan, F. Neumann, M. C. Meinke, N. Ma, M. Calderon, S. Hedtrich, M. Schafer-Korting and B. Kleuser, Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes, Nanotoxicology11 (2017) 267–277; https://doi.org/10.1080/17435390.2017.129237110.1080/17435390.2017.129237128165853
- 8. M. Schafer-Korting, U. Bock, A. Gamer, A. Haberland, E. Haltner-Ukomadu, M. Kaca, H. Kamp, M. Kietzmann, H. C. Korting, H. U. Krachter, C. M. Lehr, M. Liebsch, A. Mehling, F. Netzlaff, F. Niedorf, M. K. Rubbelke, U. Schafer, E. Schmidt, S. Schreiber, K. R. Schroder, H. Spielmann and A. Vuia, Reconstructed human epidermis for skin absorption testing: results of the German pre-validation study, Alternat. Lab. Animals34 (2006) 283–294.10.1177/02611929060340031216831060
- 9. F. M. Batz, W. Klipper, H. C. Korting, F. Henkler, R. Landsiedel, A. Luch, U. von Fritschen, G. Weindl and M. Schafer-Korting, Esterase activity in excised and reconstructed human skin-bio-transformation of prednicarbate and the model dye fluorescein diacetate, Eur. J. Pharm. Biopharm.84 (2013) 374–385; https://doi.org/10.1016/j.ejpb.2012.11.00810.1016/j.ejpb.2012.11.00823201050
- 10. L. J. Lowenau, C. Zoschke, R. Brodwolf, P. Volz, C. Hausmann, S. Wattanapitayakul, A. Boreham, U. Alexiev and M. Schafer-Korting, Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes, Eur. J. Pharm. Biopharm.116 (2017) 149–154; https://doi.org/10.1016/j.ejpb.2016.12.01710.1016/j.ejpb.2016.12.01728034807
- 11. R. J. Perera, S. Koo, C. F. Bennett, N. M. Dean, N. Gupta, J. Z. Qin and B. J. Nickoloff, Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways, J. Cell. Biochem.98 (2006) 394–408; https://doi.org/10.1002/jcb.2078510.1002/jcb.20785
- 12. J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe and F. Speleman, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol.3 (2002) RESEARCH0034.10.1186/gb-2002-3-7-research0034
- 13. X. Lei, B. Liu, W. Han, M. Ming and Y. Y. He, UVB-Induced p21 degradation promotes apoptosis of human keratinocytes, Photochem. Photobiol. Sci.9 (2010) 1640–1648; https://doi.org/10.1039/c0pp00244e10.1039/c0pp00244e
- 14. T. D. Carr, J. DiGiovanni, C. J. Lynch and L. M. Shantz, Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival, Cancer Prev. Res.5 (2012) 1394–404; https://doi.org/10.1158/1940-6207.CAPR-12-0272-T10.1158/1940-6207.CAPR-12-0272-T
- 15. J. W. Littlefield, Escape from senescence in human keratinocyte cultures, Exp. Gerontol.31 (1996) 29–32.10.1016/0531-5565(95)00018-6
- 16. G. A. Rockwell, G. Johnson and A. Sibatani, In vitro senescence of human keratinocyte cultures, Cell Struct. Funct.12 (1987) 539–548.10.1247/csf.12.5392449290
- 17. C. L. Tu, W. Chang and D. D. Bikle, The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A, J. Invest. Dermatol.131 (2011) 1119–1128; https://doi.org/10.1038/jid.2010.41410.1038/jid.2010.414307821721209619
- 18. Z. Xie, S. M. Chang, S. D. Pennypacker, E. Y. Liao and D. D. Bikle, Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation, Mol. Biol. Cell20 (2009) 1695–704; https://doi.org/10.1091/mbc.E08-07-075610.1091/mbc.e08-07-0756265524419158393
- 19. A. Dhumrongvaraporn and P. Chanvorachote, Kinetics of ultraviolet B irradiation-mediated reactive oxygen species generation in human keratinocytes, J. Cosmet. Sci.64 (2013) 207–217.
- 20. U. Wolfle, P. R. Esser, B. Simon-Haarhaus, S. F. Martin, J. Lademann and C. M. Schempp, UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo, Free Radic. Biol. Med.50 (2011) 1081–1093; https://doi.org/10.1016/j.freeradbiomed.2011.01.02710.1016/j.freeradbiomed.2011.01.02721281711
- 21. E. Takai, M. Tsukimoto, H. Harada and S. Kojima, Involvement of P2Y6 receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes, Radiat. Res.175 (2011) 358–366; https://doi.org/10.1667/RR2375.110.1667/RR2375.121388279
- 22. X. Ren, Y. Shi, D. Zhao, M. Xu, X. Li, Y. Dang and X. Ye, Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway, J. Dermatol. Sci.82 (2016) 106–114; https://doi.org/10.1016/j.jdermsci.2015.12.00810.1016/j.jdermsci.2015.12.00826908354
- 23. J. Adamus, S. Aho, H. Meldrum, C. Bosko and J. M. Lee, p16INK4A influences the aging pheno-type in the living skin equivalent, J. Invest. Dermatol.134 (2014) 1131–1133; https://doi.org/10.1038/jid.2013.46810.1038/jid.2013.468396160224335897
- 24. N. Kanda and S. Watanabe, 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression, J. Invest. Dermatol.123 (2004) 319–328; https://doi.org/10.1111/j.0022-202X.2004.12645.x10.1111/j.0022-202X.2004.12645.x15245432
- 25. S. Suomela, L. Cao, A. Bowcock and U. Saarialho-Kere, Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers, J. Invest. Dermatol.122 (2004) 717–721; https://doi.org/10.1111/j.0022-202X.2004.22322.x10.1111/j.0022-202X.2004.22322.x15086558
- 26. P. Sextius, C. Marionnet, C. Tacheau, F. X. Bon, P. Bastien, A. Mauviel, B. A. Bernard, F. Bernerd and L. Dubertret, Analysis of gene expression dynamics revealed delayed and abnormal epidermal repair process in aged compared to young skin, Arch. Dermatol. Res.307 (2015) 351–364; https://doi.org/10.1007/s00403-015-1551-510.1007/s00403-015-1551-5440964525740152
- 27. W. L. Hsieh, Y. H. Huang, T. M. Wang, Y. C. Ming, C. N. Tsai and J. H. Pang, IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes, Cell Prolif.48 (2015) 187–197; https://doi.org/10.1111/cpr.1216810.1111/cpr.12168649626225664647
- 28. H. K. Kim, Protective effect of garlic on cellular senescence in UVB-exposed HaCaT human keratinocytes, Nutrients8 (2016); https://doi.org/10.3390/nu808046410.3390/nu8080464499737727483310
- 29. W. T. Liao, J. H. Lu, C. H. Lee, C. E. Lan, J. G. Chang, C. Y. Chai and H. S. Yu, An interaction between arsenic-induced epigenetic modification and inflammatory promotion in a skin equivalent during arsenic carcinogenesis, J. Invest. Dermatol.137 (2017) 187–196; https://doi.org/10.1016/j.jid.2016.08.01710.1016/j.jid.2016.08.01727592797
- 30. G. P. Studzinski, E. Gocek and M. Danilenko, Chapter 84: Vitamin D Effects on Differentiation and Cell Cycle, in Vitamin D, 3rd ed (Eds. D. Feldman, J. W. Pike, J. S. Adams) Academic Press, San Diego 2011, pp. 1625–1656.10.1016/B978-0-12-381978-9.10084-8
- 31. H. W. Chiu, C. H. Chen, Y. J. Chen and Y. H. Hsu, Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice, PloS One12 (2017) e0174042; https://doi.org/10.1371/journal.pone.017404210.1371/journal.pone.0174042535442228301572
- 32. J. Feng, Y. Liao, X. Xu, Q. Yi, L. He and L. Tang, hnRNP A1 promotes keratinocyte cell survival post UVB radiation through PI3K/Akt/mTOR pathway, Expe. Cell Res.362 (2018) 394–399; https://doi.org/10.1016/j.yexcr.2017.12.00210.1016/j.yexcr.2017.12.00229229447