Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS
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References
- 1. M. L. Salem, Immunomodulatory and therapeutic properties of the Nigella sativa L. seed, Int. Immunopharmacol. 5 (2005) 1749–1770; https://doi.org/10.1016/j.intimp.2005.06.00810.1016/j.intimp.2005.06.008
- 2. H. Gali-Muhtasib, A. Roessner and R. Schneider-Stock, Thymoquinone: a promising anti-cancer drug from natural sources, Int. J. Biochem. Cell Biol. 38 (2006) 1249–1253; https://doi.org/10.1016/j.biocel.2005.10.00910.1016/j.biocel.2005.10.009
- 3. S. Asgary, A. Ghannadi, G. Dashti, A. Helalat, A. Sahebkard and S. Najafie, Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hyper-cholesterolemic rabbits, J. Funct. Food5 (2013) 228–234.
- 4. M. Burits and F. Bucar. Antioxidant activity of Nigella sativa essential oil, Phytother. Res.14 (2000) 323–328.10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q
- 5. M. A. Mansour, M. N. Nagi, A. S. El-Khatib and A. M. Al-Bekairi, Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action, Cell Biochem. Funct.20 (2002) 143–151; https://doi.org/10.1002/cbf.96810.1002/cbf.968
- 6. N. Erkan, G. Ayranci and E. Ayranci, Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract; blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol, Food Chem.110 (2008) 76–82; https://doi.org/10.1016/j.foodchem.2008.01.05810.1016/j.foodchem.2008.01.058
- 7. R. Cozzi, R. Ricordy, T. Aglitti, V. Gatta, P. Petricone and R. Salvia, Ascorbic acid and β-carotene as modulators of oxidative damage, Carcinogenesis18 (1997) 223–228.10.1093/carcin/18.1.223
- 8. L. B. Becker, New concepts in reactive oxygen species and cardiovascular reperfusion physiology, Cardiovasc. Res. 61 (2004) 461–470; https://doi.org/10.1016/j.cardiores.2003.10.02510.1016/j.cardiores.2003.10.025
- 9. R. Masella R. Di Benedetto, R. Varì, C. Filesi and C. Giovannini, Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes, J. Nutr. Biochem. 16 (2005) 577–586; https://doi.org/10.1016/j.jnutbio.2005.05.01310.1016/j.jnutbio.2005.05.013
- 10. R. Aeschbach, J. Löliger, B. C. Scott, A. Murcia, J. Butler, B. Halliwell and O. T. Aruoma, Anti-oxidant action of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol, Food Chem. Toxicol. 32 (1994) 31–36; https://doi.org/10.1016/0278-6915(84)90033-410.1016/0278-6915(84)90033-4
- 11. N. Y. Yanishlieva, E. M. Marinova, M. H. Gordon and V. G. Raneva, Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems, Food Chem. 64 (1999) 59–66; https://doi.org/10.1016/S0308-8146(98)00086-710.1016/S0308-8146(98)00086-7
- 12. I. A. Al-Saleh, G. Billedo and I. I. El-Doush, Level of selenium, DL-α-tocopherol, DL-γ-tocopherol, all-trans-retinol, thymoquinone and thymol in different brands of Nigella sativa seeds, J. Food Comp. Anal. 19 (2006) 167–175; https://doi.org/10.1016/j.jfca.2005.04.01110.1016/j.jfca.2005.04.011
- 13. B. Avula, Y. H. Wang, Z. Ali and I. A. Khan, Quantitative determination of chemical constituents from seeds of Nigella sativa L. using HPLC-UV and identification by LC-ESI-TOF, J. AOAC Int. 93 (2010) 1778–1787.10.1093/jaoac/93.6.1778
- 14. O. A. Ghosheh, A. A. Houdi and P. A. Crooks, High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.), J. Pharm. Biomed. Anal. 19 (1999) 757–762; https://doi.org/10.1016/S0731-7085(98)00300-810.1016/S0731-7085(98)00300-8
- 15. G. M. Hadad, R. A. Abdel Salam, R. M. Soliman and M. K. Mesbah, High performance liquid chromatography quantification of principal antioxidants in black seed (Nigella sativa L.) phytopharmaceuticals, J. AOAC Int. 95 (2012) 1043–1047.10.5740/jaoacint.11-20722970569
- 16. S. A. Pathan, G. K. Jain, S. M. A. Zaidi, S. Akhter, D. Vohora, P. Chander, P. L. Kole, F. J. Ahmad and R. K. Khar, Stability-indicating ultra-performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies, Biomed. Chromatogr. 25 (2011) 613–620; https://doi.org/10.1002/bmc.149210.1002/bmc.149220734352
- 17. L. Abou Basha, M. S. Rashed and H. Y. Aboul-Enein, TLC assay of thymoquinone in black seed oil (Nigella sativa Linn.) and identification of dithymoquinone and thymol, J. Liq. Chromatogr. Relat. Technol.18 (1995) 105–115; https://doi.org/10.1080/1082607950800922410.1080/10826079508009224
- 18. R. M.Velho-Pereira, C. R. Barhate, S. R. Kulkarni and A. G. Jagtap, Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella sativa extracts and formulations, Phytochem. Anal. 22 (2011) 367–373; https://doi.org/10.1002/pca.128910.1002/pca.128921337651
- 19. A. Michelitsch, A. Rittmannsberger, A. Hüfner, U. Rückert and W. Likussar, Determination of isopropylmethylphenols in Black seed oil by differential pulse voltammetry, Phytochem. Anal.15 (2004) 320–324.10.1002/pca.78515508837
- 20. C.-C. Toma, G. M. Simu, D. Hanganu, N. Olah, F. M. G. Vata, C. Hammami and M. Hammami, Chemical composition of the Tunisian Nigella sativa. Note I. Profile on essential oil, Farmacia58 (2010) 458–464; https://doi.org/10.1002/pca.78510.1002/pca.785
- 21. N. Ahmad, R. Ahmad, A. Al-layly, H. Al-shawi, A. Al-ali, M. Amir and A. Mostafa, Ultra-high-performance liquid chromatography-based identification and quantification of thymoquinone in Nigella sativa extract from different geographical regions, Phcog. Mag. 14 (2018) 471–480; https://doi.org/10.4103/pm.pm_119_1810.4103/pm.pm_119_18
- 22. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1), Current Step 4 version, Geneva, November 2005; http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf; 13 August 2019
- 23. L. I. Smith and R. W. H. Tess, Dithymoquinone, J. Am. Chem. Soc. 66 (1944) 1323–1324; https://doi.org/10.1021/ja01236a03610.1021/ja01236a036
Language: English
Page range: 325 - 342
Accepted on: Sep 30, 2019
Published on: Feb 17, 2020
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
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© 2020 Rabab M. Soliman, Randa A. Abdel Salam, Basma G. Eid, Ahdab Khayyat, Thikryat Neamatallah, Mostafa K. Mesbah, Ghada M. Hadad, published by Croatian Pharmaceutical Society
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