References
- 1. J. A. Arnott and S. L. Planey, The influence of lipophilicity in drug discovery and design, Expert Opin. Drug Discov. 7 (2012) 863–875; https://doi.org/10.1517/17460441.2012.714363
- 2. M. C. Wenlock, T. Potter, P. Barton and R. P. Austin, A method for measuring the lipophilicity of compounds in mixtures of 10, J. Biomol. Screen.16 (2011) 348–355; https://doi.org/10.1177/1087057110396372
- 3. Y. Dohta, T. Yamashita, S. Horiike, T. Nakamura and T. Fukami, A system for LogD screening of 96-well plates using a water-plug aspiration/injection method combined with high-performance liquid chromatography-mass spectrometry, Anal. Chem.79 (2007) 8312–8315; https://doi.org/10.1021/ac0709798
- 4. T. Yamashita, I. Nishimura, T. Nakamura and T. Fukami, A system for LogD screening of new drug candidates using a water-plug injection method and automated liquid handler, J. Lab. Autom.14 (2009) 276–281; https://doi.org/10.1016/j.jala.2008.10.001
- 5. Y. W. Alelyunas, L. Pelosi-Kilby, P. Turcotte, M. B. Kary and R. C. Spreen, A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection, J. Chromatogr. A1217 (2010) 1950–1955; https://doi.org/10.1016/j.chroma.2010.01.071
- 6. I. Nishimura, A. Hirano, T. Yamashita and T. Fukami, Improvement of the high-speed logD assay using an injection marker for the water plug aspiration/injection method, J. Chromatogr. A1216 (2009) 2984–2988; https://doi.org/10.1016/j.chroma.2009.02.004
- 7. A. Andrés, M. Rosés, C. Ràfols, E. Bosch, S. Espinosa, V. Segarra and J. M. Huerta, Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts, Eur. J. Pharm. Sci.76 (2015) 181–191; https://doi.org/10.1016/j.ejps.2015.05.008
- 8. M. Medić-Šarić, A. Mornar, T. Badovinac-Črnjević and I. Jasprica, Experimental and calculation procedures for molecular lipophilicity: comparative study for 3,3’-(2-metoxybenzylidene)bis[4-hydroxycoumarin], Croat. Chem. Acta77 (2004) 367–370.
- 9. M. Medić-Šarić, A. Mornar and I. Jasprica, Lipophilicity study of salicylamide, Acta Pharm.54 (2004) 91–101.
- 10. E. Kłosińska-Szmurło, F. A. Pluciński, M. Grudzień, K. Betjelewska-Kielak, J. Biemacka and A. P. Mazurek, Experimental and theoretical studies on the molecular properties of ciprofloxacin, norfloxacin, pefloxacin, sparfloxacin and gatifloxacin in determining bioavailability, J. Biol. Phys.40 (2014) 335–345; https://doi.org/10.1007/s10867-014-9354-z
- 11. D. Dellis, C. Giaginis and A. Tsantili-Kakoulidou, Physicochemical profile of nimesulide. Exploring the interplay of lipophilicity, solubility and ionization, J. Pharm. Biomed. Anal. 44 (2007) 57–62; https://doi.org/10.1016/j.jpba.2007.01.035
- 12. L. Hitzel, A. P. Watt and K. L. Locker, An increased throughput method for the determination of partition coefficients, Pharm. Res.17 (2000) 1389–1395; https://doi.org/10.1023/A:1007546905874
- 13. Z. Rahmani, M. Saidi, M. Yousfi and M. Dakmouche, Experimental and theoretical study on lipophilicity of novel 1,2-dithiole-3-thiones synthetic, Asian J. Chem.25 (2013) 1–5.
- 14. D. M. Wilson, X. Wang, E. Walsh and R. A. Rourick, High throughput logD determination using liquid chromatography-mass spectrometry, Comb. Chem. High T. Scr.4 (2001) 511–519; https://doi.org/10.2174/1386207013330913
- 15. M. Dołowy and A. Pyka, Lipophilicity study of salicylic and acetylsalicylic acids using both experimental and calculations methods, J. Liq. Chromatogr. R. T.38 (2015) 485–491; https://doi.org/10.1080/10826076.2014.913527
- 16. B. Lin and J. H. Pease, A novel method for high throughput lipophilicity determination by microscale shake flask and liquid chromatography tandem mass spectrometry, Comb. Chem. High T. Scr.16 (2013) 817–825; https://doi.org/10.2174/1386207311301010007
- 17. Y. Mrestani, C. Mrestani-Klaus, B. Bretschneider and R. H. Neubert, Improvement of lipophilicity and membrane transport of cefuroxime using in vitro models, Eur. J. Pharm. Biopharm.58 (2004) 653–657; https://doi.org/10.1016/j.ejpb.2004.04.008
- 18. T. A. Malik, Inflammatory bowel disease: Historical perspective, Epidemiology, and Risk Factors, Surg. Clin. North Am.95 (2015) 1105–1122; https://doi.org/10.1016/j.suc.2015.07.006
- 19. M. Fakhoury, R. Negrulj, A. Mooranian and H. Al-Salami, Inflammatory bowel disease: clinical aspects and treatments, J. Inflamm. Res.7 (2014) 113–120; https://doi.org/10.2147/JIR.S65979
- 20. S. Bangalore, G. Kamalakkannan, S. Parkar and F. H. Messerli, Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis, Am. J. Med.120 (2007) 713–719; https://doi.org/10.1016/j.amjmed.2006.08.033
- 21. T. Loftsson, Physicochemical Properties and Pharmacokinetics, in Essential Pharmacokinetics – A Primer for Pharmaceutical Scientists (Ed. T. Loftsson), 1st ed., Academic Press, Cambridge 2015, pp. 85–104.
- 22. A. Kowalska and K. Pluta, RP TLC assay of the lipophilicity of new azathioprine analogs, J. Liq. Chromatogr. Relat. Technol. 35 (2012) 1686–1696; https://doi.org/10.1080/10826076.2011.621158
- 23. A. Czyrski and B. Kupczyk, The determination of partition coefficient of 6-mercaptopurine derivatives by thin layer chromatography, J. Chem. (2013) 1–4; https://doi.org/10.1155/2013/419194
- 24. M. Chrzanowska, M. Kuehn, T. Hermann and R. H. H. Neubert, Biopharmaceutical characterization of some synthetic purine drugs, Pharmazie58 (2003) 504–506.
- 25. E. A. Enyedy, E. Farkas, O. Dömötör and M. A. Santos, Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-γ-hydroxamate derivatives with Zn(II) and human serum albumin, J. Inorg. Biochem.105 (2011) 444–453; https://doi.org/10.1016/j.jinorgbio.2010.12.008
- 26. A. Mornar, M. Damić and B. Nigović, Pharmacokinetic parameters of statin drugs characterized by reversed phase high-performance liquid chromatography, Anal. Lett.44 (2011) 1009–1020; https://doi.org/10.1080/00032719.2010.511738
- 27. N. Delchier, C. Ringling, M.-E. Cuvelier, F. Courtois, M. Rychlik and C. M. G. C. Renard, Thermal degradation of folates under varying oxygen conditions, Food Chem.165 (2014) 85–91; https://doi.org/10.1016/j.foodchem.2014.05.076
- 28. V. Somasekhar, Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations, Braz. J. Pharm. Sci.50 (2014) 793–797; https://doi.org/10.1590/S1984-82502014000400015
- 29. P. Ravisankar, K. A. Rani, C. Vinella, V. L. Sri and M. V. Bharathi, Development and Validation of Rapid RP-HPLC Method for the Determination of Azathioprine in Bulk and Pharmaceutical Dosage Form, Pharm. Lett. 7 (2015) 85–95.
- 30. K. Jogi, M. B. Rao and R. R. Raju, Development and validation of stability indicating RP-HPLC method for the estimation of methotrexate and folic acid in bulk and tablet dosage form, Int. J. Eng. Technol. Sci. Res.3 (2016) 45–53.
- 31. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1), Current Step 4 version, November 2005; https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf; access date May 5, 2019.
- 32. M. Chrzanowska, J. Sobiak, M. Kuehn, E. Dorawa and T. Hermann, Partition coefficients of some purine derivatives and its application to pharmacokinetics, Pharmazie64 (2009) 804–806; https://doi.org/10.1691/ph.2009.9181
- 33. X. Liu, B. Testa and A. Fahr, Lipophilicity and its relationship with passive drug permeation, Pharm. Res.28 (2011) 962–977; https://doi.org/10.1007/s11095-010-0303-7
- 34. J. Fallingborg, Intraluminal pH of the human gastrointestinal tract, Dan. Med. Bull.46 (1999) 183–196.
- 35. M. A. Hofsäss, J. de Souza, N. M. Silva-Barcellos, K. R. Bellavinha, B. Abrahamsson, R. Cristofoletti, D. W. Groot, A. Parr, P. Langguth, J. E. Polli, V. P. Shah, T. Tajiri, M. U. Mehta and J. B. Dressman, Biowaiver monographs for immediate-release solid oral dosage forms: Folic acid, J. Pharm. Sci.106 (2017) 3421–3430; https://doi.org/10.1016/j.xphs.2017.08.007