Have a personal or library account? Click to login
Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents Cover

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Open Access
|Mar 2019

References

  1. 1. N. C. Desai, H. Somani, A. Trivedi, K. Bhatt, L. Nawale, V. M. Khedkar, P. C. Jha and D. Sarkar, Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents, Bioorg. Med. Chem. Lett. 26 (2016) 1776–1783; https://doi.org/10.1016/j.bmcl.2016.02.04310.1016/j.bmcl.2016.02.043
  2. 2. A. G. Banerjee, N. Das, S. A. Shengule, R. S. Srivastava and S. K. Shrivastava, Synthesis, characterization, evaluation and molecular dynamics studies of 5,6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti–inflammatory and analgesic agents, Eur. J. Med. Chem. 101 (2015) 81–95; https://doi.org/10.1016/j.ejmech.2015.06.02010.1016/j.ejmech.2015.06.020
  3. 3. W. Wu, Q. Chen, A. Tai, G. Jiang and G. Ouyang, Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives, Bioorg. Med. Chem. Lett. 25 (2015) 2243–2246; https://doi.org/10.1016/j.bmcl.2015.02.06910.1016/j.bmcl.2015.02.069
  4. 4. S. Zhang, Y. Luo, L. Q. He, Z. J. Liu, A. Q. Jiang, Y. H. Yang and H. L. Zhu, Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity, Bioorg. Med. Chem. 21 (2013) 3723–3729; https://doi.org/10.1016/j.bmc.2013.04.04310.1016/j.bmc.2013.04.043
  5. 5. R. A. Rane, S. D. Gutte and N. U. Sahu, Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent, Bioorg. Med. Chem. Lett. 22 (2012) 6429–6432; https://doi.org/10.1016/j.bmcl.2012.08.06110.1016/j.bmcl.2012.08.061
  6. 6. Y. Kotaiah, N. Harikrishna, K. Nagaraju and C. V. Rao, Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives, Eur. J. Med. Chem. 58 (2012) 340–345; https://doi.org/10.1016/j.ejmech.2012.10.00710.1016/j.ejmech.2012.10.007
  7. 7. N. C. Desai, N. Bhatt, H. Somani and A. Trivedi, Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles, Eur. J. Med. Chem. 67 (2013) 54–59; https://doi.org/10.1016/j.ejmech.2013.06.02910.1016/j.ejmech.2013.06.029
  8. 8. M. Mahesh, G. Bheemaraju, G. Manjunath and P. V. Ramana, Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy) acetohydrazide analogs as potential antibacterial and antifungal agents, Ann. Pharm. Fran. 74 (2016) 34–44; https://doi.org/10.1016/j.pharma.2015.07.00210.1016/j.pharma.2015.07.002
  9. 9. J. Wu, B. Song, H. Chen, P. Bhadury and D. Hu, Synthesis and antifungal activity of 5-chloro-6-phenylpyridazin-3(2H)-one derivatives, Molecules14 (2009) 3676–3687; https://doi.org/10.3390/molecules1409367610.3390/molecules14093676
  10. 10. J. D. S. Chaves, L. G. Tunes, C. H. de J. Franco, T. M. Francisco, C. C. Corrêa, S. M. F. Murta, R. L. Monte-Neto, H. Silva, A. P. S. Fontes and M. V. de Almeida, Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents, Eur. J. Med. Chem. 127 (2017) 727–739; https://doi.org/10.1016/j.ejmech.2016.10.05210.1016/j.ejmech.2016.10.052
  11. 11. P. Puthiyapurayil, B. Poojary, C. Chikkanna and S. K. Buridipad, Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents, Eur. J. Med. Chem. 53 (2012) 203–210; https://doi.org/10.1016/j.ejmech.2012.03.05610.1016/j.ejmech.2012.03.056
  12. 12. S. Bansal, M. Bala, S. K. Suthar, S. Choudhary, S. Bhattacharya, V. Bhardwaj, S. Singla and A. Joseph, Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity, Eur. J. Med. Chem. 80 (2014) 167–174; https://doi.org/10.1016/j.ejmech.2014.04.04510.1016/j.ejmech.2014.04.045
  13. 13. S. R. Desai, U. Laddi, R. S. Bennur, P. A. Patil and S. Bennur, Synthesis and pharmacological activities of some new 5-substituted-2-mercapto-1,3,4-oxadiazoles, Indian J. Pharm. Sci. 73 (2011) 593–596; https://doi.org/10.4103/0250-474X.9902510.4103/0250-474X.99025
  14. 14. E. De Clercq, T. Sakuma, M. Baba, R. Pauwels, J. Balzarini, I. Rosenberg and A. Holy, Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines, Antiviral Res. 8 (1987) 261–272; https://doi.org/10.1016/S0166-3542(87)80004-910.1016/S0166-3542(87)80004-9
  15. 15. K. A. El-Sharkawy, N. N. E. El-Sayed and M. Y. Zaki, Uses of 2-amino-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carbonitrile in the synthesis of heterocyclic compounds with anticonvulsant, behavioral and CNS antidepressant activities, Int. Res. J. Pure Appl. Chem. 2 (2012) 91–104; https://doi.org/10.9734/IRJPAC/2012/122210.9734/IRJPAC/2012/1222
  16. 16. M. Albratty, K. A. El-Sharkawy and M. S. Alam, Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives, Acta Pharm. 67 (2017) 15–33; https://doi.org/10.1515/acph-2017-000410.1515/acph-2017-0004
DOI: https://doi.org/10.2478/acph-2019-0015 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 261 - 276
Accepted on: Nov 5, 2018
Published on: Mar 28, 2019
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:

© 2019 Mohammed Albratty, Karam Ahmed El-Sharkawy, Hassan Ahmed Alhazmi, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.