Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations

Eduardo José Barbosa; Humberto Gomes Ferraz

doi:10.2478/acph-2019-0007

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Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations

Acta Pharmaceutica

Volume 69 (2019): Issue 1 (March 2019)

By: Eduardo José Barbosa and Humberto Gomes Ferraz

Open Access

|Dec 2018

Abstract

The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 3² factorial design was realized, with binder and diluent factors at three levels each. Pellets were produced by the extrusion/spheronization technique, and dried in a fluid-ized bed. Physical tests and dissolution tests were conducted. The results showed that the binder factor was not significant for pellet size and granulometry distribution. Rather, trends of a different response of gellan gum were identified, in comparison with PVP, in aspect ratio and dissolution tests: more round pellets were obtained in formulations with gellan gum, and more variable dissolution resulted when this polysaccharide was present. Therefore, if the usage of this compound in immediate release pellet formulations is verified, this justifies the interest in the development of sustained release systems using gellan gum.

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Articles in this issue

DOI: https://doi.org/10.2478/acph-2019-0007 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 99 - 109

Accepted on: Sep 7, 2018

Published on: Dec 7, 2018

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

gellan gum,

polyvinylpyrrolidone,

pellets,

Related subjects:

© 2018 Eduardo José Barbosa, Humberto Gomes Ferraz, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 69 (2019): Issue 1 (March 2019)