References
- 1. J. K. Ryu, H. S. Kim and D. H. Nam, Biotechnol. Bioprocess Engin., 17 (2012) 900-911; http://doi.org/10.1007/s12257-012-0095-1
- 2. J. Wang, V. Yadav, A. L. Smart, S. Tajiri and A. W. Basit, Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs, Mol. Pharm. 12 (2015) 966–973; http://doi.org/10.1021/mp500809f
- 3. O. Zupančič and A. Bernkop-Schnürch, Lipophilic peptide character – What oral barriers fear the most?, J. Control. Release255 (2017) 242–257; http://doi.org/10.1016/j.jconrel.2017.04.038
- 4. K. Park, I. C. Kwan and K. Park, Oral protein delivery: current status and future prospect, React. Funct. Polym.71 (2011) 280–287; http://doi.org/10.1016/j.reactfunctpolym.2010.10.002
- 5. D. Vllasaliu, R. Exposito-Harris, A. Heras, L. Casettari, M. Garnett, L. Illum and S. Stolnik, Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution, Int. J. Pharm. 400 (2010) 183–193; http://doi.org/10.1016/j.ijpharm.2010.08.020
- 6. G. Camenisch, J. Alsenz, H. V. Waterbeemd and G. Folkers, Estimation of permeability by passive diffusion through Caco-cell monolayers using the drugs’ lipophilicity and molecular weight, Eur. J. Pharm. Sci.6 (1998) 317–324; http://doi.org/10.1016/S0928-0987(97)10019-7
- 7. B. F. Choonara, Y. E. Choonara, P. Kumar, D. Bijukumar, L. C. du Toit and V. Pillay, A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules, Biotechnol. Adv.32 (2014) 1269–1282; http://doi.org/10.1016/j.biotechadv.2014.07.006
- 8. T. Jung, W. Kamm, A. Breitenbach, E. Kaiserling, J. X. Xiao and T. Kissel, Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50 (2000) 147–160; http://doi.org/10.1016/S0939-6411(00)00084-9
- 9. P. Ahlin Grabnar and J. Kristl, The manufacturing techniques of drug-loaded polymeric nanoparticles from preformed polymers, J. Microencaps. 28 (2011) 323–335; http://doi.org/10.3109/02652048.2011.569763
- 10. J. Mirtič, J. Ilaš and J. Kristl, Influence of different classes of crosslinkers on alginate polyelectrolyte nanoparticle formation, thermodynamics and characteristics, Carbohydrate polymers181 (2018) 93–102; http://doi.org/10.1016/j.carbpol.2017.10.040
- 11. A. T. Florence, Nanoparticle uptake by the oral route: Fulfilling its potential? Drug Discovery Today: Technologies2 (2005) 75–81; http://doi.org/10.1016/j.ddtec.2005.05.019
- 12. L. Yin, J. Ding, C. He, L. Cui, C. Tang and C. Yin, Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery, Biomaterials30 (2009) 5691–5700; http://doi.org/10.1016/j.biomaterials.2009.06.055
- 13. Y. Li, X. Chen and N. Gu, Computational investigation of interaction between nanoparticles and membranes: Hydrophobic/hydrophilic effect, J. Phys. Chem. B.112 (2008) 16647–16653; http://doi.org/10.1021/jp8051906
- 14. J. Renukuntla, A. D. Vadlapudi, A. Patel, S. H. S. Boddu and A. K. Mitra, Approaches for enhancing oral bioavailability of peptides and proteins, Int. J. Pharm.447 (2013) 75–93; http://doi.org/10.1016/j.ijpharm.2013.02.030
- 15. C. Contini, M. Schneemilch, S. Gaisford and N. Quirkedoi, Nanoparticle-membrane interactions, J. Exper. Nanosci.13 (2018) 62–81; http://doi.org/10.1080/17458080.2017.1413253
- 16. Y. Xiao, M. R. Wiesner, Characterization of surface hydrophobicity of engineered nanoparticles, J. Hazard. Mater,215–216 (2012) 146–151; http://doi.org/10.1016/j.jhazmat.2012.02.043
- 17. J. A. Patel and S. Garde, Efficient method to characterize the context-dependent hydrophobicity of proteins, Phys. Chem. B. 118 (2014) 1564–1573; http://doi.org/10.1021/jp4081977
- 18. A. Hawe, M. Sutter and W. Jiskoot, Extrinsic fluorescent dyes as tools for protein characterization, Pharm. Res.25 (2008) 1487–1499; http://doi.org/10.1007/s11095-007-9516-9
- 19. D. Matulis, R. Lovrien, 1-Anilino-8-naphthalene sulfonate anion-protein binding depends primarily on ion pair formation, Biophys. J.74 (1998) 422–429; http://doi.org/10.1016/S0006-3495(98)77799-9
- 20. B. Press and D. Di Grandi, Permeability for intestinal absorption: Caco-2 assay and related issues, Curr. Drug Metab.9 (2008) 893–900; http://doi.org/10.2174/138920008786485119
- 21. I. Hubatsch, E. G. Ragnarsson and P. Artursson, Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers, Nat. Protoc. 2 (2009) 2111–2119; http://doi.org/10.1038/nprot.2007.303
- 22. K. Berginc, S. Žakelj, L. Levstik, D. Uršič and A. Kristl, Fluorescin transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum, Eur. J. Pharm. Biopharm. 66 (2007) 281–285; http://doi.org/10.2016/j.ejpb.2006.10.023
- 23. M. Cegnar, B. Podobnik, S. Caserman, M. Homar and J. Kerc, EPO Compositions for Oral Administration, WO2015/032973 (A1), 12 Mar 2015.
- 24. M. Marušič, T. Zupančič, G. Hribar, R. Komel, G. Anderluh and S. Caserman, The Caco-2 cell culture model enables sensitive detection of enhanced protein permeability in the presence of N-decyl-ß-D-maltopyranoside, New Biotechnologies30 (2013) 507–515; http://doi.org/10.1016/j.nbt.2013.05.008
- 25. C. L. Cooper, P. L. Dubin, A. B. Kayitmazer and S. Turksen, Polyelectrolyte-protein complexes, Curr. Opin. Colloid. Interface Sci.10 (2005) 52–78, http://doi.org/10.1016/j.cocis.2005.05.007
- 26. P. Maurel, Relevance of dielectric constant and solvent hydrophobicity to the organic solvent effect in enzymology, J. Biol. Chem.253 (1978) 1671–1683.
- 27. E. Y. Chi, S. Krishnan, T. W. Randolph and J. F. Carpenter, Physical stability of proteins in aqueous solution: mechanism and driving forces in non-native protein aggregation, Pharm. Res. 20 (2003) 1325–1336; http://doi.org/10.1023/A:1025771421906
- 28. A. M. M. Sadeghi, F. A. Dorkoosh, M. R. Avadi, M. Weinhold, A. Bayat, F. Delie, R. Gurny, B. Larijani, M. Rafiee-Tehrani and H. E. Junginger, Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells, Eur. J. Pharm. Biopharm. 70 (2008) 270–278; http://doi.org/10.1016/j.ejpb.2008.03.004.29
- 29. M. A. Mohammed, J. T. M. Syeda, K. M. Wasan and E. K. Wasan, An overview of chitosan nanoparticles and its application in non-parenteral drug delivery, Pharmaceutics9 (2017) E53; http://doi.org/10.3390/pharmaceutics9040053
- 30. I. Pereira de Sousa, C. Steiner, M. Schmutzler, M. D. Wilcox, G. J. Veldhuis, J. P. Pearson, C. W. Huck, W. Salvenmoser and A. Bernkop-Schnürch, Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles, Eur. J. Pharm. Biopharm. 97 (2015) 273–279; http://doi.org/10.1016/j.ejpb.2014.12.024