A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

Perković, Ivana; Džolić, Zrinka Rajić; Zorc, Branka

doi:10.2478/acph-2013-0023

Abstract

A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.

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A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

Abstract

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