Skip to main content
Have a personal or library account? Click to login
Cyclodextrin based nanosponges for pharmaceutical use: A review Cover

Cyclodextrin based nanosponges for pharmaceutical use: A review

Acta Pharmaceutica
Volume 63 (2013): Issue 3 (September 2013)
By: ,   and    
Open Access
|Oct 2013
References

References

  1. 1. L. Guo, G. Gao, X. Liu and F. Liu, Preparation and characterization of TiO2 nanosponge,.(2008) 322-325; DOI: 10.1186/1556-276X-6-551.
    Open DOISearch in Google Scholar
  2. 2. D. Farrell, S. Limaye and S. Subramanian,, U.S. Pat 0,251,561A1, 9 Nov 2006.
    Search in Google Scholar
  3. 3. V. Dakankov, M. Llyin, M. Tsyurupa, G. Timofeeva and L. Dubronina, From a dissolved polystyrene coil to intramolecularly hyper cross linked nanosponges,(1998) 8398-8403; DOI: 10.1021/ma951673i.
    Open DOISearch in Google Scholar
  4. 4. S. Swaminathan, L. Pastero, L. Serpe, F. Trotta, P. Vavia, D. Aquilano, M. Trotta, G. Zara and R. Cavalli, Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity,(2010) 193-201; DOI: 10.1016/ j.ejpb.2009.11.003.
    Open DOISearch in Google Scholar
  5. 5. F. Melani, P. Mura, M. Adamo, F. Maestrelli, P. Gratteri and C. Bonaccini, New docking CFF91 parameters specific for cyclodextrin inclusion complexes,(2003) 280-292; DOI: 10.1016/S0009-2614(03)00126-X.
    Open DOISearch in Google Scholar
  6. 6. P. Couvreur and C. Vauthier, Nanotechnology: intelligent design to treat complex disease,(2006) 1417-1450; DOI: 10.1007/s11095-006-0284-8.
    Open DOISearch in Google Scholar
  7. 7. C. Zhang, N. Awasthi, M. A. Schwarz, S. Hinz and R. E. Schwarz, Superior antitumor activity of nanoparticle albumin-bound paclitaxel in experimental gastric cancer, PLoS One.(2013) e58037; DOI: 10.1371/journal.pone.0058037.
    Open DOISearch in Google Scholar
  8. 8. Y. Fukumori and H. Ichikawa, Nanoparticles for cancer therapy and diagnosis,(2006) 1-28; DOI: 10.1163/156855206775123494.
    Open DOISearch in Google Scholar
  9. 9. M. Morishita and N. Peppas, Is the oral route possible for peptide and protein drug delivery,(2006) 905-910; DOI: 10.1007/s11095-006-0284-8.
    Open DOISearch in Google Scholar
  10. 10. H. Cohen, R. Levy, J. Gao, I. Fishbein, V. Kousaev, S. Sosnowski, S. Slomkowski and G. Golomb, Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles,.(2000) 1896-1905; DOI: 10.1038/sj.gt.3301318.
    Open DOISearch in Google Scholar
  11. 11. L. Grislain, P. Couvreur, V. Lenaerts, M. Roland, D. Deprez-Decampeneere and P. Speiser, Pharmacokinetics and distribution of a biodegradable drug-carrier,(1983) 335-345; DOI: 10.1016/0378-5173(83)90166-7.
    Open DOISearch in Google Scholar
  12. 12. L. Illum, S. S. Davis, C. G. Wilson, N. W. Thomas, M. Frier and J. G. Hardy, Blood clearance and organ deposition of intravenously administered colloidal particles, The effects of particle size, nature and shape,(1982) 135-146; DOI: 10.1016/0378-5173(82)90113-2.
    Open DOISearch in Google Scholar
  13. 13. P. Couvreur, B. Kante, V. Lenaerts, V. Scailteur, M. Roland and P. Speiser, Tissue distribution of antitumor drugs associated with polyalkylcyanoacrylate nanoparticles,(1980) 199-202; DOI: 10.1002/jps.2600690222.
    Open DOISearch in Google Scholar
  14. 14. J. Kreuter,in(Ed. J. Swarbrick and J. C. Boylan), Marcel Dekker In., New York 1994, pp.165-190.
    Search in Google Scholar
  15. 15. J. Xing, D. Zhang and T. Tan, Studies on the oridonin-loaded poly(D,L-lactic acid) nanoparticlesand,(2007) 153-158; DOI: 10.1016/j.ijbiomac.2006. 07.001.
    Search in Google Scholar
  16. 16. E. Garcia-Garcia, K. Andrieux, S. Gil and P. Couvreur, Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain,(2005) 274-292; DOI: 10.1016/j.ijpharm.2005.03.031.
    Open DOISearch in Google Scholar
  17. 17. S. Subramanian, A. Singireddy, K. Krishnamoorthy and M. Rajappan, Nanosponges: A Novel Class of Drug Delivery System - Review,.(2012) 103-111.
    Search in Google Scholar
  18. 18. A. Nokhodchi, M. Jelvehgari, M. Reza Siahi and M. Reza Mozafar, Factors affecting the morphology of benzoyl peroxide microsponges,(2007) 834-840, DOI: 10.1016/j.micron. 2007.06.012.
    Search in Google Scholar
  19. 19. F. Trotta and R. Cavalli, Characterization and application of new hyper-cross-linked cyclodextrins,(2009) 39-48, DOI: 10.1163/156855408X379388.
    Open DOISearch in Google Scholar
  20. 20. F. Trotta, R. Cavalli, V. Tumiatti, O. Zerbinati, C. Roggero and R. Vallero,, EP Pat 1786841A1, 23May, 2007.
    Search in Google Scholar
  21. 21. S. Eki, T. Lei, L. Jingquan, J. Zhongfan, B. Cyrille and P. D. Thomas, Biodegradable star polymers functionalized with b-cyclodextrin inclusion complexes,,(2009) 2699-2707; DOI: 10.1021/bm900646g.
    Open DOISearch in Google Scholar
  22. 22. S. Swaminathan, R. Cavalli, F. Trotta, P. Ferruti, E. Ranucci, I. Gerges, A. Manfredi, D. Marinotto and P. Vavia, In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of b-cyclodextrin,(2010) 183-191; DOI: 10.1007/s10847-010-9765-9.
    Open DOISearch in Google Scholar
  23. 23. A. Vyas, S. Saraf and S. Saraf, Cyclodextrin based novel drug delivery systems,(2008) 23-42; DOI: 10.1007/s10847-008-9456-y.
    Open DOISearch in Google Scholar
  24. 24. T. Girek and W. Ciesielski, Polymerization of b-cyclodextrin with maleic anhydride along with thermogravimetric study of polymers,(2010) 1-7; DOI: 10. 1007/s10847-010-9778-4.
    Search in Google Scholar
  25. 25. D. Li and M. Ma, Nanosponges: From inclusion chemistry to water purifying technology,(1999) 26-28.
    Search in Google Scholar
  26. 26. C. Rajeswari, A. Alka, A. Javed and R. Khar, Cyclodextrins in drug delivery: an update review,.(2005) E329-E357; DOI: 10.1208/pt060243.
    Open DOISearch in Google Scholar
  27. 27. A. Modi and P. Tayade, Comparative solubility enhancement profile of valdecoxib with different solubilization approaches,.(2007) 427-430; DOI: 10.4103/0250-474X. 33156.
    Search in Google Scholar
  28. 28. R. Cavalli, F. Trotta and W. Tumiatti, Cyclodextrin-based nanosponges for drug delivery,(2006) 209-213; DOI: 10.1007/s10847-006-9085-2.
    Open DOISearch in Google Scholar
  29. 29. F. Trotta, V. Tumiatti, R. Cavalli, C. Roggero, B. Mognetti and G. Berta,, WO 2009/003656 A1; 2009.
    Search in Google Scholar
  30. 30. F. Trotta and T. Wander,, WO 2003/085002, US20050154198 A1, 14 July. 2005.
    Search in Google Scholar
  31. 31. S. Swaminathan, P. Vavia, F. Trotta and S. Torne, Formulation of beta-cyclodextrin based nanosponges of Itraconazole,.(2007) 89-94; DOI: 10.1007/s10847-006-9216-9.
    Open DOISearch in Google Scholar
  32. 32. A. Mele, F. Castiglione, L. Malpezzi, F. Ganazzoli, G. Raffaini, F. Trotta, B. Rossi, A. Fontana and G. Giunchi, HR MAS NMR, powder XRD and Raman spectroscopy study of inclusion phenomena in b-CD nanosponges,.(2011) 403-409; DOI: 10.1007/ s10847-010-9772-x.
    Open DOISearch in Google Scholar
  33. 33. S. Swaminathan, P. Vavia, F. Trotta, R. Cavalli, P. Ferruti, E. Ranucci and I. Gerges, Release modulation and conformational stabilization of a model protein by use of swellable nanosponges of b-cyclodextrin, First European Cyclodextrin Conference, Aalborg, Denmark 2009.
    Search in Google Scholar
  34. 34. S. Torne, K. Ansari, P. Vavia, F. Trotta and R. Cavalli, Enhanced oral bioavailability after administration of paclitaxel-loaded nanosponges,.(2010) 419-425; DOI: 10.3109/ 10717541003777233.
    Open DOISearch in Google Scholar
  35. 35. K. Ansari, P. Vavia, F. Trotta and R. Cavalli, Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study,,(2011) 279-286; DOI: 10.1208/s12249-011-9584-3.
    Open DOISearch in Google Scholar
  36. 36. E. Patel and R. Oswal, Nanosponge and micro sponges: a novel drug delivery system,(2012) 237-244.
    Search in Google Scholar
  37. 37. T. Loftsson and M. Brewster, Pharmaceutical applications of cyclodextrins: drug solubilization and stabilization,(1996) 1017-1025; DOI: 10.1021/js950534b.
    Open DOISearch in Google Scholar
  38. 38. A. Radi and S. Eissa, Electrochemical study of indapamide and its complexation with b-cyclodextrin,.(2011) 95-102; DOI: 10.1007/s10847-010.9906-1.
    Open DOISearch in Google Scholar
  39. 39. H. Bricout, F. Hapiot, A. Ponchel, E. Monflier and S. Tilloy, Chemically modified cyclodextrins: an attractive class of supramolecular hosts for the development of aqueous biphasic catalytic processes(2009) 924-945; DOI: 10.3390/su1040924.
    Open DOISearch in Google Scholar
  40. 40. H. Dodziuk,in(Ed. H. Dodziuk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2006, pp. 1-30.
    Open DOISearch in Google Scholar
  41. 41. D. Li and M. Ma, Nanosponges for water purification,.(2000) 112-16; DOI: 10.1007/s100980000061.
    Open DOISearch in Google Scholar
  42. 42. E. Bilensoy and A. Atilla,, in: Drug Discovery, Development, and Manufacturing, John Wiley & Sons Inc. Publishers 2010; DOI: 10.1002/9780470259818.ch31.
    Open DOISearch in Google Scholar
  43. 43. R. Lala, A. Thorat and C. Gargote, Current trends in b-cyclodextrin based drug delivery systems,(2011) 1520-1526.
    Search in Google Scholar
  44. 44. B. Mamba, R. Krause, T. Malefetse and S. Sithhole, Cyclodextrin nanosponges in the removal of organic matter to produce water for power generation,,(2008) 657-660.
    Open DOISearch in Google Scholar
  45. 45. B. Mamba, R. Krause, T. Malefetse, S. Mhlanga, S. Sithhole, K. Salipira and E. Nxumalo, Removal of geosmin and 2-methylisoborneol (2-MIB) in water from Zuikerbosch water treatment plant (Rand Water) using b-cyclodextrin polyurethane,,(2007) 223-228.
    Search in Google Scholar
  46. 46. S. Tang, L. Kong, J. Ou, Y. Liu, X. Li and H. Zou, Application of cross-linked b-cyclodextrin polymer for adsorption of aromatic amino acid,(2006) 39-48; DOI: 10.1002/jmr.756.
    Open DOISearch in Google Scholar
  47. 47. F. Trotta, R. Cavalli, S. Swaminathan, C. Sarzanini and P. Vavia, Novel functionalized nanosponges: synthesis, characterization. Safety assessment, cytotoxicity testing and interaction studies. Proceedings of the 14th International Cyclodextrin Symposium, Kyoto 2008, pp. 338-342.
    Search in Google Scholar
  48. 48. G. Yurtdas, M. Demirel and L. Genc, Inclusion complexes of fluconazole with b-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation,(2011) 429-435; DOI: 10.1007/s10847-010-9908-z.
    Open DOISearch in Google Scholar
  49. 49. A. Rasheed, Cyclodextrins as drug carrier molecule: a review,(2008) 567-598; DOI: 10.3797/scipharm.0808-05.
    Open DOISearch in Google Scholar
  50. 50. P. Sinko, Martin’s, 5th ed., Lippincott Williams & Williams Publishers, Philadelphia 2006, p.466.
    Search in Google Scholar
  51. 51. T. Govender, S. Stolnik, M. Garnett, L. Illum and S. Davis, PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug,(1999) 171-185; DOI: 10.1016/S0168-3659(98)00116-3.
    Open DOISearch in Google Scholar
  52. 52. S. Galindo-Rodriguez, E. Allémann, H. Fessi and E. Doelker, Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion and nanoprecipitation methods,(2004) 1428-1439; DOI: 10.1023/B:PHAM.0000036917.75634.be.
    Open DOISearch in Google Scholar
  53. 53. M. Leroueil-Le Verger, L. Fluckiger, Y. Kim, M. Hoffman and P. Maincent, Preparation and characterization of nanoparticles containing an antihypertensive agent,(1998) 137-143; DOI: 10.1016/S0939-6411(98)00015-0.
    Open DOISearch in Google Scholar
  54. 54. N. Santos-Magalhães, H. Fessi, F. Puisieux, S. Benita and M. Seiller, An in-vitro release kinetic examination and comparative evaluation between submicron emulsion and polylactic acid nanocapsules of clofibride,(1995) 195-205; DOI: 10.3109/02652049509015290.
    Open DOISearch in Google Scholar
  55. 55. A. Layre, R. Gref, J. Richard, D. Requier, H. Chacun, M. Appel, A. Domb and P. Couvreur, Nanoencapsulation of a crystalline drug,(2005) 323-327; DOI: 10.1016/j. ijpharm.2005.02.039.
    Open DOISearch in Google Scholar
  56. 56. D. Lemoine, C. Francois, F. Kedzierewicz, V. Preat, M. Hoffman and P. Maincent, Stability study of nanoparticles of poly(b-caprolactone), poly(D,L-lactide) and poly(D,L-lactideco-glycolide),(1996) 2191-2197. DOI: 10.1016/0142-9612(96)00049-X.
    Open DOISearch in Google Scholar
  57. 57. Y. Jeong, Y. Shim, C. Kim, G. Lim, K. Choi and C. Yoon, Effect of cryoprotectants on the reconstitution properties of surfactant-free nanoparticles of poly (D,L-lactide-co-glycolide),(2005) 593-601; DOI: 10.1080/02652040500162659.
    Open DOISearch in Google Scholar
  58. 58. H. Redhead, S. Davis and L. Illum, Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation,(2001) 353-363; DOI: 10.1016/S0168-3659(00)00367-9.
    Open DOISearch in Google Scholar
  59. 59. M. Bivas-Benita, S. Romeijn, H. Junginger and G. Borchard, PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium,(2004) 1-6; DOI: 10.1016/j.ejpb. 2004.03.008.
    Search in Google Scholar
  60. 60. R. Pecora, Dynamic light scattering measurement of nanometer particles in liquids(2000) 123-131; DOI: 10.1023/A:1010067107182.
    Open DOISearch in Google Scholar
  61. 61. M. Santander-Ortega, A. Jódar-Reyes, N. Csabac, D. Bastos-González and J. Ortega-Vinuesa, Colloidal stability of Pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms,(2006) 522-529; DOI: 10.1016/j.jcis.2006.07.031.
    Open DOISearch in Google Scholar
  62. 62. Y. Ishikawa, Y. Katoh and H. Ohshima, Colloidal stability of aqueous polymeric dispersions: effect of pH and salt concentration,B(2005) 53-58; DOI: 10.1016/j.colsurfb.2005. 01.006.
    Search in Google Scholar
  63. 63. J. Shar, T. Obey and T. Cosgrove, Adsorption studies of polyether’s- Part1: Adsorption onto hydrophobic surfaces, Colloid Surf A:(1998) 21-33, DOI: 10.1016/S0927-7757(97)00182-9.
    Open DOISearch in Google Scholar
  64. 64. E. Leo, B. Brina, F. Forni and M. Vandelli, In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form,(2004) 133-141, DOI: 10. 1016/j.ijpharm.2004.03.002.
    Open DOISearch in Google Scholar
  65. 65. U. Bilati, E. Allemann and E. Doelker, Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles,(2005) 67-75; DOI: 10.1016/j.ejps.2004.09.011.
    Open DOISearch in Google Scholar
  66. 66. M. Bivas-Benita, S. Romeijn, H. Junginger and G. Borchard, PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium,.(2004) 1-6; DOI: 10.1016/j.ejpb. 2004.03.008.
    Search in Google Scholar
  67. 67. H. Fessi, F. Puisieux, J. Devissaguet, N. Ammoury and S. Benita, Nanocapsule formation by interfacial polymer deposition following solvent displacement,.(1989) R1-R4; DOI: 10.1016/0378-5173(89)90281-0.
    Open DOISearch in Google Scholar
  68. 68. M. Chorny, I. Fishbein, H. D. Danenberg and G. Golomb, Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics,(2002) 389-400; DOI: 10.1016/S0168-3659(02)00211-0.
    Open DOISearch in Google Scholar
  69. 69. V. Mosqueira, P. Legrand, H. Pinto-Alphandary, F. Puisieux and G. Barratt, Poly (D,L-lactide) nanocapsules prepared by a solvent displacement process: influence of the composition on physicochemical and structural properties,.(2000) 614-626; DOI: 10.1002/(SICI) 1520-6017(200005)89:5<614::AID-JPS7>3.0.CO;2-7.
    Search in Google Scholar
  70. 70. J. Ren, H. Hong, J. Song and T. Ren, Particle size and distribution of biodegradable poly-D,L- -lactide-co-poly(ethylene glycol) block polymer nanoparticles prepared by nanoprecipitation,(2005) 1884-1890; DOI: 10.1002/app.22070.
    Open DOISearch in Google Scholar
  71. 71. M. Teixeira, M. Alonso, M. Pinto and C. Barbosa, Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3methoxyxanthone,.(2005) 491-500; DOI: 10.1016/j.ejpb.2004.09.002.
    Open DOISearch in Google Scholar
  72. 72. M. Tobìo, R. Gref, A. Sanchez, R. Langer and M. Alonso, Stealth PLA-PEG nanoparticles as protein carriers for nasal administration,(1998) 276-279; DOI: 10.1023/A:1011922 819926.
    Search in Google Scholar
  73. 73. H. Brittain, D. Bogdanowich, J. DeVincentis, G. Lewen and A.Newman, Physical characterization of pharmaceutical solids,(1991) 963-973. DOI: 10.1023/A:1015888520352.
    Open DOISearch in Google Scholar
  74. 74. M. Hombreiro-Perez, J. Siepmann, C. Zinutti, A. Lamprecht, N. Ubrich, M. Hoffman, R. Bodmeier and P. Maincent, Non-degradable microparticles containing a hydrophilic and/or a lipophilic drug: preparation, characterization and drug release modeling,(2003) 413-428; DOI: 10.1016/S0168-3659(03)00030-0.
    Open DOISearch in Google Scholar
  75. 75. M. Guyot and F. Fawaz, Nifedipine loaded-polymeric microspheres: preparation and physical characteristics,(1998) 61-74; DOI: 10.1016/S0378-5173(98)00253-1.
    Open DOISearch in Google Scholar
  76. 76. Y. Jeong, Y. Shim, K. Song, Y. Park, H. Ryu and J. Nah, Testosterone encapsulated surfactant-free nanoparticles of poly(D,L-lactide-co-glycolide): preparation and release behavior,(2002) 1579-1584.
    Search in Google Scholar
  77. 77. R. Suryanarayanan,, inVol. 70 (Ed. H. G. Brittain), Marcel Dekker Inc., New York 1995, pp.187-221.
    Open DOISearch in Google Scholar
  78. 78. J. Alongi, M. Skovi, A. Frache and F. Trotta, Novel flame retardants containing cyclodextrin nanosponges and phosphorus compounds to enhance EVA combustion properties,(2010) 2093-2100; DOI: 10.1016/j.polymdegradstab.2010.06.030.
    Open DOISearch in Google Scholar
  79. 79. G. Gilardi, F. Trotta, R. Cavalli, P. Ferruti, E. Ranucci, G. Di Nardo, C. Roggero and V. Tumiatti,WO2009149883 A1, 17 Dec.2009.
    Search in Google Scholar
  80. 80. S. Renuka, B. W. Roderick and P. Kamla, Evaluation of the kinetics and mechanism of drug release from Econazole Nitrate nanosponge loaded carbopol hydrogel,(2011) 25-31.
    Search in Google Scholar
  81. 81. S. Renuka and P. Kamla, Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation,(2011) 367-376; DOI: 10.3109/10837451003739289.
    Open DOISearch in Google Scholar
  82. 82. S. Baboota, R. Khanna, S. Agarwal, J. Ali and A. Ahuja,: An update, Available from Pharma. info. net., 2003, accessed on 13/01/2011.
    Search in Google Scholar
  83. 83. V. N. Wong, G. Fernando, A. R. Wagner, J. Zhang, G. R. Kinsel, S. Zauscher and D. J. Dyer, Separation of peptides with polyionic nanosponges for MALDIMS analysis,(2009) 1459-1465; DOI: 10.1021/la802723r.
    Open DOISearch in Google Scholar
  84. 84. A. Jenny, P. Merima, F. Alberto and T. Francesco, Role of b-cyclodextrin nanosponges in polypropylene photooxidation,(2011) 127-135; DOI: 10.1016/j.carbpol.2011.04. 022.
    Search in Google Scholar
  85. 85. K. William, S. Benjamin and H. Eva,, www.Vanderbilt.edu, accessed on 20.12.2011.
    Search in Google Scholar
  86. 86. L. Wenting, Y. Cheng, N. Masaki, F. Gaku, M. Tadashi, M. Andrea, C. Franca, C. Fabrizio, T. Francesco and I. Yoshihisa, Cyclodextrin nanosponge-sensitized enantiodifferentiating photoisomerization of cyclooctene and 1,3-cyclooctadiene,(2012) 1305-1311; DOI: 10.3762/bjoc.8.149.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.2478/acph-2013-0021 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Journal RSS Feed
Language: English
Page range: 335 - 358
Published on: Oct 22, 2013
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Keywords:
nanosponges,
solubility enhancement,
cyclodextrin
Related subjects:
Pharmacy,
Pharmacy, other

© 2013 Gursalkar Tejashri, Bajaj Amrita, Jain Darshana, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 63 (2013): Issue 3 (September 2013)
Previous article
Next article