Synthesis and pharmacophore modeling of novel quinazolines bearing a biologically active sulfonamide moiety
Open Access
|Mar 2013References
- 1. M.M. Ghorab, S. E. Barakat, H. M. Saker andM. M. Abd Rabo, Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety,.(2006) 665-670; DOI: 10.1002/chin.200703141.
- 2. S. E. Barakat, M. M. Ghorab, H. M. Saker and M. M. Abd Rabo, Novel quinazolinone derivatives as possible antitumor agents,(2007) 65-77; DOI: 10.1080/ 10426500600867042.
- 3. M. M. Ghorab, S. M. Abdel-Gawad and M. S. A. El-Gaby, Synthesis and evaluation of some new fluorinated hydroquinazoline derivatives as antifungal agents,(2000) 249-255; DOI: 10.1016/S0014-827X(00)00029-X.
- 4. S. M. Abdel-Gawad, M. S. A. El-Gaby and M. M. Ghorab, Synthesis and antifungal activity of novel pyrano[2’,3’:4,5]thiazolo[2,3-]quinazolines, pyrido[2’,3’:4,5]thiazolo[2,3-]quinazolines and pyrazolo[2’,3’:4,5]thiazolo[2,3-]quinazolines,(2000) 287-292; DOI: 10.1016/S0014- -827X(00)00042-2.
- 5. M.M. Ghorab, S. G. Abdel-Hamide, M. S. A. El-gaby and S. M. El-Sayed, Synthesis and effect of some new [1,2,4]triazolo [4,3-a]quinazolin-5(4)-ones and related compounds on Ehrlich ascites carcinoma cells,(1999) 1-10.
- 6. M.M. Ghorab, S. G. Abdel-Hamide and S. M. El-Sayed, Novel quinazolone derivatives as antitumor agents,(1998) 57-68; DOI: 10.1080/10426509808029666.
- 7. S. Jantova, D. Hudecova, S. Stankova and L. Ruzekova, Antibacterial effect of substituted 4-quinazolylhydrazines and their arylhydrazones determined by a modified microdilution method,(1995) 611-614; DOI: 10.1007/BF02818517.
- 8. N. B. Patel, J. C. Patel and G. G. Barat, Synthesis and antimicrobial activity of 2-[2-(2,6-dichlorophenyl) amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones,(2010) 173-182; DOI: 10.4103/0975-1483.63165.
- 9. V. Gupta, S. K. Kashaw, V. Jatav and P. Mishra, Synthesis and antimicrobial activity of some new 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazoline-4(3H)-ones,.(2008) 205-211; DOI: 10.1007/s00044-007-9054-3.
- 10. P. Kumar, C. Nath, K. P. Bhargava and K. Shanker, Synthesis and antiparkinsonian activity of styryl quinazolones,(1982) 802-804.
- 11. F. Roubinek, J. Vavrina and Z. Budesinsky, 3-Aminoalkyl- and 3-benzyl-4(3H)-quinazolinones,.(1982) 630-635; DOI: 10.1135/cccc19820630.
- 12. G. Y. Zhixiong, R. K. Bakshi,M. Chen, S. P. Rohrer, S. D. Feighner, S. S. Pong, A. D. Howard, A. Blake, E. T. Birzin, L. Locco, R. M. Parmar, W. W. S. Chan, J. M. Schaeffer, R. G. Smith, A. A. Patchett and R. P. Nargaund, Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues,(2000) 5-8; DOI: 10.1016/S0960-894X(99)00584-3.
- 13. V. Alagarsamy, S. Murugesan, K. Dhanabal, M. Murugan and E. De Clercq, Anti-HIV, antibacterial and antifungal activities of some novel 2-methyl-3-(substituted methylamino)-(3)-quinazolin-4-ones,(2007) 304-307; DOI: 10.4103/0250-474X.33167.
- 14. S. K. Pandey, A. Singh, A. Singh and A. Nizamuddin, Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings,(2009) 1188-1197; DOI: 10.1016/j.ejmech.2008.05.033.
- 15. S. Jantova, R. Ovadekova, S. Letasiova, K. Spirkova and S. Stankovsky, Antimicrobial activity of some substituted triazoloquinazolines,(2005) 90-94; DOI: 10.1007/BF02931453.
- 16. M. S. Al-Said, M. M. Ghorab, M. S. Al-Dosari and M. M. Hamed, Synthesis andanticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety,(2011) 201-207; DOI: org/10.1016/j.ejmech.2010.11.002.
- 17. M. M. Ghorab, E. Noaman, M. M. F. Ismail, Y. A. Ammar, H. I. Heiba and M. Y. Sayed, Novel antitumor and radioprotective sulfonamides containing pyrrolo[2,3-]pyrimidines,(2006) 405-413; DOI: 10.1002/chin.200643177.
- 18. M. M. Ghorab, Z. H. Ismail, S. M. Abdel-Gawad and A. Abdel Aziem, Antimicrobial activity of amino acid, imidazole, and sulfonamide derivatives of pyrazolo[3,4-]pyrimidine,.(2004) 57-62; DOI: 10.1002/hc.10212.
- 19. Y. Genç, R. Özkanca and Y. Bekdemir, Antimicrobial activity of some sulfonamide derivatives on clinical isolates of(2008) 17-23; DOI: 10.1186/1476-0711-7-17.
- 20. M. S. Al-Said, M. S. Bashandy, S. I. Al-Qasoumi and M. M. Ghorab, Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives,(2011) 137-141; DOI: 10.1016/j.ejmech.2010.10.024.
- 21. S. Guccion, A. Raffaelli, G. V. Barretta, L. M. Scolaro, S. Pucci and F. Russo, Potential of alkyl orthoformates as alkylating agents of non-electron rich nitrogen heterocycles,(1995) 1149-1158; DOI: 10.1002/jhet.5570320409.
- 22. Y. Murti, A. K. Singh and D. Pathak, New 6-bromo-2-methyl-3-(substituted phenyl)-(3)-quinazolin-4-ones with antimicrobial and antiinflammatory activities,(2011) 333-337; DOI: 10.4103/0250-474X.93512.
- 23. Z. H. Chohan, M. H. Youssoufi, A. Jarranpour and T. B. Hadda, Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives,.(2010) 1189-1199; DOI: 10.1016/j.ejmech.2009.11.029.
- 24. G. Wolber and T. Langer, LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters,(2005) 160-169; DOI: 10.1021/ ci049885e.
- 25. S. Friederike, L. Sven, H. Thomas, S. Karsten, L. F. Philip and H. Hans-Dieter, Pharmacophore definition and three-dimensional quantitative structure-activity relationship study on structurally diverse prostacyclin receptor agonists,(2002) 1103-1111; DOI: 10.1124/ mol.62.5.1103.
- 26. S. John, S. Thangapandian, S. Sakkiah and K. W. Lee, Potent bace-1 inhibitor design using pharmacophore modeling,screening and molecular docking studies,(2011) S1-S28; DOI: 10.1186/1471-2105-12-S1-S28.
- 27. J. Garín, E. Meléndez, F. L. Merchán, P. Merino, J. Orduna, T. Tejero, Synthesis of unsymmetrical diheteroarylbenzenes: Benzoazole and quinazoline derivatives,.(1991) 359-363; DOI: 10.1002/jhet.5570280229.
- 28. I. Graefe, K. Kottke, H. Kuehmstedt and D. Knoke, Synthesis of 3-hetaryl-4-oxo-2-thioxo- and 3-heterotaryl-2,4-dioxo-1,2,3,4-tetrahydroquinazolines,(1990) 530-531;(1991); DOI: 10.1002/chin.199148179.
- 29. A. A. Fahmi, S. C. Mekki, H. A. Alber, A. S. Shawlai, H. N. Hassaneen and H. Abdelhamid, A Facile synthesis of some pyrazolo analogues of tricyclic purine derivative via hydrazonoyl halides,(1994) 140-149.
- 30. J. Fathi, V. Masand, R. Jawarkar, R. Mouhoub and T. Ben Hadda, POM as efficient tools to predict and improve both antibacterial and antifungal activity of aryl aldazines,.(2011) 57-68.
Language: English
Page range: 1 - 18
Published on: Mar 12, 2013
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
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© 2013 Mostafa M. Ghorab, Zienab H. Ismail, Awwad A. Radwan, Mohamad Abdalla, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.