Stages of AKI according to KDIGO 2012
| Stage | sCr (μ mol/l) | Diuresis |
|---|---|---|
| 1 | 1.5 – 1.9 times the baseline value | <0.5ml/kg/hour for 6 – 12 hours |
| 2 | ||
| 3 | 2.0 – 2.9 times the baseline value | <0.5ml/kg/hour for ≥ 12 hours |
| 3.0 times the baseline value | < 0.3ml/kg/hour for ≥ 24 hours | |
Diagnostic criteria of HRS-AKI according to ICA
| Cirrhosis, acute liver failure, acute liver failure in the field of its chronic disease |
| 26.5 μ mol/l increase in sCr over 48 hours or ≥ 50% increase from baseline and/or diuresis < 0.5 ml/kg/hr for ≥ 6 hours |
| Absence of a decrease in sCr after 2-day discontinuation of diuretics and albumin volume expansion, the recommended dose of albumin is 1 g/kg body weight, maximum 100g |
| Absence of shock |
| Exclusion of recent administration of nephrotoxic drugs |
| Exclusion of parenchymal kidney damage |
| Suspected renal vasoconstriction at FENa < 0.2% (values < 0.1% indicate high risk) |
Stages of CKD according to KDIGO
| Albuminuria (mg/g) | ||||
|---|---|---|---|---|
| GFR categories | eGFR (ml/min/1.73 m2) | A1 | A2 | A3 |
| <30 | 30–299 | ≥300 | ||
| G1 | ≥ 90 | |||
| G2 | 60 – 89 | |||
| G3a | 45 – 59 | |||
| G3b | 30 – 44 | |||
| G4 | 15 – 29 | |||
| G5 | < 15 | |||
AKI risk factors after liver transplantation
| Pre-transplant | Perioperative | Post-transplant |
|---|---|---|
| AKI | Hypotension | CNI |
| CKD | Postreperfusion syndrome | Nephrotoxic drugs |
| Obesity | Blood loss | Diuretics |
| Hypertension | Number of transfusions | Infections |
| Diabetes | Oliguria | |
| Hepatitis B, C | ||
| HCC | ||
| Alcoholic liver disease | ||
| Donor age > 60 years | ||
| BMI ≥ 30 years | ||
| Cold ischemia time | ||
| Warm ischemia time | ||
| Marginal donor | ||
| Infections |