What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Adamcakova Jana; Mokra Daniela

doi:10.2478/acm-2021-0011

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What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Acta Medica Martiniana

Volume 21 (2021): Issue 3 (December 2021)

By: Adamcakova Jana and Mokra Daniela

Open Access

|Dec 2021

Abstract

Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO₂) or silica. Although pathomechanisms of the disease have not been fully elucidated, oxidative stress has been recognized as a fundamental factor triggering a fibrotizing inflammation leading to irreversible changes in lung tissue. Based on this knowledge, therapeutic potential of various antioxidants has been intensively discussed. Among them, N-acetylcysteine with its multiple anti-inflammatory and antioxidant actions and a long-term experience with its clinical use in various diseases appears as a very promising choice. The purpose of this article is to review the therapeutic effects of N-acetylcysteine particularly in relation to a lung injury and to point out a potential of N-acetylcysteine in the treatment of lung silicosis.

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