Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers

Martina Neuschlová; R. Pecova

doi:10.2478/acm-2013-0003

Abstract

Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Cough is a major symptom in some people with asthma. Cough reflex sensitivity (CRS) test with capsaicin is one of the most important method for cough studying. Cough reflex sensitivity was defined as the lowest concentration of capsaicin that elicited 2 or more (C2) and 5 or more coughs (C5). The aim of this study was to find out a cough reflex sensitivity in patients with asthma bronchiale and in healthy volunteers. In the present study we conclude that cough reflex sensitivity was significantly increased in asthmatic adult patients compared with healthy adult volunteers.

References

1. March ME, Sleiman PM, Hakonarson H. The Genetics of Asthma and Allergic Disorders. Discov Med 2011; 11 (56): 35-45.
Search in Google Scholar
2. Borges MC, Ferraz E, Vianna EO. Bronchial provocation tests in clinical practice. Sao Paulo Med J 2011; 129 (4): 243-9.10.1590/S1516-3180201100040000821971900
Search in Google Scholar
3. Canning BJ. Afferent nerves regulating the cough reflex: Mechanisms and mediators of cough in disease. Otolaryngol Clin North Am 2010; 43 (1): 15-vii.10.1016/j.otc.2009.11.012288253520172253
Search in Google Scholar
4. Dinh QT, Suhling H, Fisher A, Braun A, Welte T. Innervation of the airways in asthma bronchiale and chronic obstructive pulmonary disease (COPD). Pneumologie 2011; 65 (5): 283-92.10.1055/s-0030-125612321271508
Search in Google Scholar
5. Leung SY, Niimi A, Williams AS, Nath P, Blanc FX, Dinh QT, Chung KF. Inhibition of citric acid- and capsaicininduced cough by novelTRPV-1 antagonist, V112220, in guinea-pig. Cough 2007; 3: 10.10.1186/1745-9974-3-10226209018154688
Search in Google Scholar
6. Birrel MA, Belvisi MG, Grace M, Sadofsky L, Farugi S, Hele DJ, Maher SA, Freund-Michel V, Morice AH. TRPA1 agonists evoke coughing in guinea-pig and human volunteers. Am J Respir Crit Care Med 2009; 180 (11): 1042-47.10.1164/rccm.200905-0665OC278441119729665
Search in Google Scholar
7. Taylor-Clark TE, Nassenstein C, McAlexander MA, Undem BJ. TRPA1: a potential target for antitussive therapy. Pulm Pharmacol Ther 2009; 22 (2): 71-4.10.1016/j.pupt.2008.12.01919150409
Search in Google Scholar
8. Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J. ERS guidelines on the assessment of cough. Eur Respir J 2007; 29: 1256-76.10.1183/09031936.0010100617540788
Search in Google Scholar
9. Korpas J, Tomori Z. Cough and Other Respiratory Reflexes. Basel: S Karger; 1979.
Search in Google Scholar
10. Doherty MJ, Mister R, Pearson MG, Calverly PM. Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 2000; 55: 643-9.10.1136/thorax.55.8.643174582810899239
Search in Google Scholar
11. Pecova R, Michnova T, Fabry J, Zatko T, Neuschlova M, Tomori Z. Influence of aspiration reflex on cough reflex sensitivity in asthmatic children. In: Sepiashvili R, editor. Allergy, asthma & immunology: from genes to clinical application. Bologna: Medimond; 2011. p. 101-4.
Search in Google Scholar
12. Nakajima T, Nishimura Y, Nishiuma T, Kotani Y, Nakata H, Yokoyama M. Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. Allergology Int 2006; 55: 149-55.10.2332/allergolint.55.14917075251
Search in Google Scholar
13. Ekstrand Y, Ternesten-Hasséus E, Arvidsson M, Löfdahl K, Palmqvist M, Millqvist E. Sensitivity to environmental irritants and capsaicin cough reaction in patients with a positive methacholine provocation test before and after treatment with inhaled corticosteroids. J Asthma 2011; 48 (5): 482-9.10.3109/02770903.2011.57040521486197
Search in Google Scholar
14. Dicpinigaitis PV, Alva RV. Safety of capsaicin cough challenge testing. Chest 2005; 128: 196-202.10.1378/chest.128.1.19616002935
Search in Google Scholar
15. Collier JG, Fuller RW. Capsaicin inhalation in man and the effects of sodium cromoglycate. Br J Pharmacol 1984; 81: 113-7.10.1111/j.1476-5381.1984.tb10750.x19869416423016
Search in Google Scholar
16. Tatar M, Karcolova D, Pecova R, Kollarik M, Plevkova J, Brozmanova M. Experimental modulation of the cough reflex. Eur Respir Rev 2002; 12: 264-9.
Search in Google Scholar
17. Fujimura M, Sakamoto S, Kamio Y, Bando T, Kurashima K, Matsuda T. Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects. Thorax 1993; 48: 615-618.10.1136/thx.48.6.6154645848346491
Search in Google Scholar

Cough Reflex Sensitivity Testing in Asthmatic Patients and Healthy Volunteers

Abstract

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