Figure 1
Heat map representations of differentially expressed genes belonging to the “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. Arbitrary signal intensity acquired from microarray analysis is represented by colors (green, higher; red, lower expression). Log2 signal intensity values for any single gene were resized to Row Z-Score scale (from -2, the lowest expression to +2, the highest expression for single gene)
Table 1
Gene symbols, fold changes in expression, corrected p values and LogFC of studied genes
| GENE SYMBOL | FOLD CHANGE | ADJUSTEDP, VALUE | LOGFC |
|---|---|---|---|
| ID2 | 0,063 | 4,74*10^5 | -1,201 |
| VEGFA | 0,070 | 1,91*10^3 | -1,157 |
| BTG2 | 0,074 | 9,55*10^5 | -1,129 |
| CCND2 | 0,122 | 1,79*10^4 | -0,914 |
| EDNRA | 0,167 | 1,85*10^3 | -0,777 |
| TGFBR3 | 0,197 | 4,06*10^4 | -0,707 |
| GJA1 | 0,207 | 1,08*10^4 | -0,684 |
| LAMA2 | 0,220 | 7,95*10^4 | -0,658 |
| RTN4 | 0,231 | 2,75*10^2 | -0,636 |
| CDK6 | 0,248 | 6,04*10^3 | -0,606 |
| IHH | 0,305 | 5,51*10^4 | -0,516 |
| MAGED1 | 0,306 | 7,06*10^4 | -0,515 |
| INSR | 0,316 | 1,91*10^3 | -0,500 |
| CD9 | 0,329 | 6,33*10^3 | -0,482 |
| PTGES | 0,337 | 1,21*10^3 | -0,472 |
| TXNIP | 0,356 | 7,81*10^4 | -0,449 |
| ITGB1 | 0,366 | 3,71*10^3 | -0,436 |
| SMAD4 | 0,368 | 1,24*10^3 | -0,434 |
| MAP3K1 | 0,369 | 2,47*10^2 | -0,433 |
| NOTCH2 | 0,385 | 2,52*10^3 | -0,415 |
| IGFBP7 | 0,404 | 2,50*10^3 | -0,394 |
| KLF10 | 0,405 | 6,85*10^3 | -0,392 |
| KIT | 0,430 | 2,56*10^3 | -0,366 |
| TPM1 | 0,434 | 1,63*10^3 | -0,363 |
| PLD1 | 0,468 | 1,10*10^2 | -0,329 |
| BTG3 | 0,486 | 4,03*10^2 | -0,314 |
| CD47 | 0,487 | 9,29*10^3 | -0,313 |
| MITF | 0,492 | 6,33*10^3 | -0,308 |
Figure 2
The circle plot showing the differently expressed genes and z-scores of “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. The outer circle shows a scatter plot for each term of the fold change of the assigned genes. Greencircles display up- regulation and red ones down- regulation. The inner circle shows the z-score of each GO BP term. The width of each bar corresponds to the number of genes within GO BP term and the color corresponds to the z-score
Figure 3
The representation of the mutual relationship between differently expressed genes that belongs to the “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. The ribbons indicate which gene belongs to which categories. The middle circle represents logarithm from fold change (LogFC). The genes were sorted by logFC from most to least changed gene. The color of the each LogFC bar corresponds with LogFC value
Figure 4
Heatmap showing the gene occurrence between differently expressed genes that belongs to the “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. The yellow color is associated with gene occurrence in the GO Term. The intensity of the color is corresponding to amount of GO BP terms that each gene belongs to
Figure 5
STRING-generated interaction network between genes that belongs to the “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. The intensity of the edges reflects the strength of interaction score
Figure 6
Functional interaction (FI) between differently expressed genes that belongs to the “regulation of cell migration” and “regulation of cell proliferation” GO BP terms. In following figure “->” stands for activating/catalyzing, “-|” for inhibition, “-” for FIs extracted from complexes or inputs, and “---” for predicted FIs