Antioxidant Properties of Resveratrol and its Protective Effects in Neurodegenerative Diseases
References
- [1] Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta(1-42)peptide. J. Neurochem. 2009; 110: 1445-1456.
- [2] Amri A, Chaumeil JC, Sfa r S, Charrueau C. Administration of resveratrol: What formulation solutions to bioavailability limitations? J Control Release. 2012; 10; 158(2): 182-193.
- [3] Ashu J And Flint Beal M. Mitochondrial Dysfunction in Neurodegenerative Diseases. J Pharmacol Exp Ther. 2012; 342(3): 619-630.
- [4] Balcerczyk A, Pirola L. Therapeutic potential of activators and inhibitors of sirtuins. BioFactors. 2010; 36(5): 383-393.
- [5] Candelario-Jalil E, Slawik H, Ridelis I, Waschbischa, Akundi RS, Hull M, Fiebich BL. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. Journal of Molecular Neuroscience. 2005; 27(3): 303-310.
- [6] Canto C, Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab. 2009; 7: 325-331.
- [7] Camont L, Cottart CH, Rhayem Y, Nivet-Antoine V, Djelidi R, Collin F, Beaudeux JL, Bonnefont- Rousselot D. Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions. Anal Chim Acta. 2009; 634(1): 121-128.
- [8] Carrizzo A, Forte M, Damato A, Trimarco V, Salzano F, Bartolo M, Maciag A, Puca AA, Vecchione C. Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Food Chem Toxicol. 2013; 61: 215-226.
- [9] Catalgol B, Batirel S, Taga Y, Ozer NK. Resveratrol: French paradox revisited. Front Pharmacol. 2012; 3: 141.
- [10] Cao H, Pan X, Li C, Zhou C, Deng F, Li T. Density functional theory calculations for resveratrol. Bioorg Med Chem Lett. 2003; 13(11): 1869-1871.
- [11] Caruso F, Tanski J, Villegas-Estrada A, Rossi M. Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure. J Agric Food Chem. 2004; 52(24): 7279-7285.
- [12] Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-{kappa}B signaling. J. Biol. Chem. 2005; 280: 40364-40374.
- [13] Chen CY, Jang JH, Li MH, Surh YJ. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun. 2005; 331(4): 993-1000.
- [14] Clark J, Silvaggi JM, Kiselak T, Zheng K, Clore EL, Dai Y, Bass CE, Simon DK. Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PLoS One. 2012; 7(11): e48925.
- [15] Cordova-Gomez M, Galano A, Raul J, Alvarez-Idaboy JR. Piceatannol, a better peroxyl radical scavenger than resveratrol. RSC Advances. 2013; 3: 20209-20218.
- [16] Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell. 2010; 142: 320-332.
- [17] Donmez G, Quteiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol. Med. 2013; 5: 344-352.
- [18] Delmas D, Aires V, Limagne E, Dutatarte P, Mazue F, Ghiringhelli F, Latruffe N. Transport, stability, and biological activity of resveratrol. Ann N Y Acad Sci. 2011; 1215: 48-59.
- [19] Delmas D, Jannin B, Latruffe N. Resveratrol: natural properties against atherosclerosis, associated pro-inflammatory effects and aging. Molecular Nutrition & Food Research. 2005, 49(5): 377-395
- [20] Dudka J, Gieroba R, Korga A, Burda n F, Matysiak W, Jodlowska-Jedrych B, Mandziuk S, Korobowicz E, Murias M. Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity. Evidence-Based Complementary and Alternative Medicine. 2012; Article ID 60618: 10.
- [21] Feng Y, Wang XP, Yang SG, Wang YJ, Zhang X, Dua XT, Suna XX, Zhao M, Huang L, Liu RT . Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. NeuroToxicology. 2009; 30(6): 986-995.
- [22] Franco SS, De Falco L, Ghaffa ri S, Brugnara C, Sinclair DA, Matte A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmele P, Cappellini MD, Michan S, Zoratti E, Janin A, De Franceschi L. Resveratrol accelerates erythroid maturation by activation of FOXO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 2014; 99(2): 267-275.
- [23] Fukui M, Yamabe N, Kang KS, Zhu BT. Growth-stimulatory effect of resveratrol in human cancer cells. Mol Carcinog. 2010; 49(8): 750-759.
- [24] Gao J, Wang WY, Mao YW, Graff J, Guan JS, Pan L. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010; 466: 1105-1109.
- [25] Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010; 464(7285): 121-125.
- [26] Holthoff JH, Woodling KA, Doerge DR, Burns ST, Hinson JA, Mayeux PR. Resver at r ol , a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochem Pharmacol. 2010; 80(8): 1260-1265.
- [27] Hurst WJ, Glinski JA, Miller KB, Apgar J, Davey MH, Stuart DA. Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products. J Agric Food Chem. 2008; 24: 56(18): 8374-8378.
- [28] Hussein Mohammed A. A Convenient Mechanism for the Free Radical Scavenging Activity of Resveratrol, International Journal of Phytomedicine. 2011; 3: 459-469.
- [29] Iuga C, Alvarez-Idaboy JR, Russo N. Antioxidant activity of trans-resveratrol toward hydroxyl and hydroperoxyl radicals: a quantum chemical and computational kinetics study. J Org Chem. 2012; 77(8): 3868-3877.
- [30] Iwahara T, Bonasio R, Narendra V, Reinberg D. SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol.Cell.Biol. 2012; 32: 5022-5034.
- [31] Jensen JS, Wertz CF, O‘neill VA. Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid). J Agric Food Chem. 2010; 58(3): 1685-1690.
- [32] Juan ME, Gonzalez-Pons E, Munuera T, Ballester J, Rodriguez-Gil JE, Planas JM. Trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr. 2005; 135(4): 757-760.
- [33] Julien C, Tremblay C, Emond V, Lebbadi M, Salem N Jr., Bennett DA. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2009; 68: 48-58.
- [34] Karuppag ounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int. 2009; 54(2): 111-118.
- [35] Kavas GO, Ayral PA, Elhan AH. The Effects of Resveratrol on Oxidant/Antioxidant Systems and Their Cofactors in Rats. Adv Clin Exp Med. 2013; 22(2): 151-155.
- [36] Kincaidand B, Bossy-Wetzel. Forever young: SIRT3 a shield against mitochondrial melt down, aging, and neurodegeneration. Frontiers in aging neurodegenearation. Front Aging Neurosci. 2013; 5: 48.
- [37] Kopeć A, Piątkowska E, Leszczyńska T, Bieżanowska-Kopeć R. Health-promoting affects of resveratrol [in Polish]. ŻYWNOŚĆ. Nauka. Technologia. Jakość. 2011; 5(78): 5-15
- [38] Krstic D, Knuesel I. Deciphering the mechanism underlying late-onset Alzheimer disease. Nat. Rev. Neurol. 2013; 9: 25-34.
- [39] Ladiwala AR, Lin JC, Bale SS, Marcelino-Cruz AM, Bhattacharya M, Dordcik JS, Tessier PM. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers. J Biol Chem. 2010; 285(31): 24228-24237.
- [40] Li Y, Cao Z, Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol. Res. 2006; 53: 6-15.
- [41] Li F, Gong Q, Dong H, Shi J. Resveratrol, A Neuroprotective Supplement for Alzheimer’s Disease. Curr Pharm Des. 2012; 18(1): 27-33.
- [42] Lin TK, Chen SD, Chuang YC, Lin HY, Huang CR, Chuang JH, Wang PW, Huang SH, Tiao MM, Chen JB, Liou CW. Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy. Int J Mol Sci. 2014; 15(1): 1625-1646.
- [43] Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ. Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur.J.Neurol. 2009; 16: 297-309.
- [44] Mahal Hs, Mukherjee. Scavenging of reactive oxygen radicals by resveratrol: antioxidant effect. Research on Chemical Intermediates. 2006; 32(1): 59-71.
- [45] Marabaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem. 2005; 280(45): 37377-37382.
- [46] Martin OJ, Lai L, Soundarapa ndian MM, Leone TC, Zorzano A, Keller MP, Attie AD Muoio DM, Kelly DP. A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth. Circ Res. 2014; 114(4): 626-636.
- [47] Mccall CE, Elgazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprograming during acute systemic inflammation. J. Leukoc.Biol. 2011; 90: 439-446.
- [48] Medzhitov R, Horng T. Transcriptional control of the inflammatory response. Nat.Rev.Immunol. 2009; 9: 692-703.
- [49] Michan S, Sinclair. Sirtuins in mammals: insights into their biological function. Biochem J. 2007; 404(1): 1-13.
- [50] Mikstacka R, Ignatowicz E. Chemopreventive and therapeutic affects of trans-resveratrol and its analogues in neoplastic diseases [in Polish]. Pol Merk Lek 2010; 168: 496-500.
- [51] Miller NJ, Rice-Evans CA. Antioxidant activity of resveratrol in red wine. Clinical Chemistry. 1995; 41: 1789.
- [52] Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010; 67: 953-966.
- [53] Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013; 5: 53.
- [54] Mokni M, Elkahoui S, Limam F, Amri M, Aouani E. Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat. Neurochemical Research. 2007; 32; 6: 981-987.
- [55] Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009; 137(3): 560-570.
- [56] Ng F, Tang BL. Sirtuins’ modulation of autophagy. J Cell Physiol. 2013; 228(12): 2262-70.
- [57] Olas B. Resveratrol as a benefactor in prophylaxis of diseases in circulatory system [in Polish]. Kosmos problemy nauk biologicznych, Polskie Towarzystwo Przyrodników im. Kopernika. 2006; 55, 2-3: 271-272.
- [58] Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofa lo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem. 2010; 285(11): 8340-8351
- [59] Park SJ, Ahmad F, Philp A, Baar K, Williams T, Lou H, Ke H, Rehmann H, Taussig R, Brown, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012; 148: 487-501.
- [60] Pope D, Madura JD, Cascio. M. β-Amyloid and Neprilysin Computational Studies Identify Critical Residues Implicated in Binding Specificity. J. Chem. Inf. Model. 2014.
- [61] Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010; 12: 662-667.
- [62] Quincozes-Santos A, Gottfried C. Resveratrol modulates astroglial functions: neuroprotective hypothesis. Ann N Y Acad Sci. 2011; 1215: 72-78.
- [63] Richard T, Pawlus AD, Iglesias ML, Pedrot E,Waffo-Teguo P,Merillon JM, Monti JP. Neuroprotective properties of resveratrol and derivatives. Ann N Y Acad Sci. 2011; 1215: 103-108.
- [64] Riederer BM, Leuba G, Vernay A, Riederer IM. The role of the ubiquitin proteasome system in Alzheimer’s disease. Exp Biol Med (Maywood). 2011; 236(3): 268-76.
- [65] Robb EL, Page MM, Wiens BE, Stuart JA. Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD. Biochem. Biophys. Res. Commun. 2008; 367: 406-412.
- [66] Rocha KK, Souza GA, Ebaid GX, Seiva FR, Cantaneo AC, Novelli EL. Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem Toxicol. 2009; 47(6): 1362-1367.
- [67] Rodacka A, Strumillo J, Serafin E, Puchala M. Effect of Resveratrol and Tiron on The Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase Induced by Superoxide Anion Radical. Curr Med Chem. 2014; 21(8):1061-1069.
- [68] Rovilllain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema Rh et al. Activation of nuclear factor-kappaB signalling promotes cellular senescence. Oncogene 2011; 30: 2356-2366.
- [69] Ryan MJ, Jackson JR, Hao Y, Williamson CL, Dabkowski ER, Hollander JM, Alway SE. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010; 65(8): 815-831.
- [70] Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 2007; 26: 5489-5504.
- [71] Scapag nini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Mol Neurobiol. 2011; 44(2): 192-201.
- [72] Seo AY, Joseph AM, Dutta D, Hwang JCY, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J. Cell Sci. 2010; 123: 2533-2542.
- [73] Son Y, Lee JH, Chung HT, Pae HO. Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1. Oxid Med Cell Longev. 2013; 639541.
- [74] Spa nier G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, Forstermann U, Li H. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol. 2009; 60(4): 111-116.
- [75] Strumiłło J, Rodacka A, Puchała M. Relationship between structural lack of order and function in inherently unordered proteins [in Polish]. Postępy Biologii Komórki. 2013; 40(4): 602-627.
- [76] Sueishi Y, Hori M. Nitric oxide scavenging rates of solubilized resveratrol and flavonoids. Nitric Oxide. 2013; 29: 25-29.
- [77] Szewczuk LM, Forti L, Stivalala, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004; 279(21): 22727-22737.
- [78] Tadolini B, Juliano C, Piu L, Franconi F, Cabrini L. Resveratrol inhibition of lipid peroxidation. Free Radic Res. 2000; 33(1): 105-114
- [79] Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol.Cell. 2010; 40: 893-904.
- [80] Tennen RI, Michishita-Kioi E, Chua KF. Finding a Target for Resveratrol. Cell. 2012; 148, 3: 387-389.
- [81] Trela BC, Waterhouse AL. Resver at r ol : Isomeric molar absorbivities and stability. J. Agric. Food Chem. 1996; 44: 1253-1257.
- [82] Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E. Sirt 7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008; 102(6): 703-710.
- [83] Van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterek RH, Nollen EA. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoSGenet. 2008; 4(3): e1000027.
- [84] Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, Ma QY, Mukhopad hyay P, Nalini N, Pezzuto JM, Richard T, Shukla Y, Surh YJ, Szekeres T, Szkudelski T, Walle T, Wu JM. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PloS One. 2011; 6(6): 19881.
- [85] Vian MA, Tomao V, Gallet S, Coulomb PO, Lacombe JM. Simple and rapid method for cis- and trans- resveratrol and piceid isomers determination in wine by high-performance liquid chromatography using chromolith columns. J Chromatogr A. 2005; 2, 1085(2): 224-229.
- [86] Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science. 2009; 323: 1063-1066.
- [87] Wu PF, Xie N, Zhang JJ, Guan XL, Zjou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem. 2013; 24(6): 1070-1077.
- [88] Yang J, Wang N, Li J, Zhang J, Feng P. Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells. Endocrine. 2010; 37(2): 365-372.
- [89] Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA et al. Modulation of NF-kBdependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004; 23: 2369-2380.
- [90] Yu LY , Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY, Liu J. Inhibition of STAT3 Expression and Signaling in Resveratrol-Differentiated Medulloblastoma Cells. Neoplasia. 2008; 10(7): 736-744.
- [91] Zhong L, D’urso A, Toiber D, Sebastian C, Henry RE, Vaddysirisack DD, Guimaraes A, Marinelli B, Wiksstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW , Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010; 140(2): 280-293
DOI: https://doi.org/10.2478/acb-2014-0006 | Journal eISSN: 2544-3577 (formerly 2080-2218)
Language: English
Page range: 97 - 117
Published on: Dec 30, 2014
Published by: Foundation for Cell Biology and Molecular Biology
In partnership with: Paradigm Publishing Services
Related subjects:
© 2014 Joanna Gerszon, Aleksandra Rodacka, Mieczysław Puchała, published by Foundation for Cell Biology and Molecular Biology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.