Isoflavonoids − Dual Action on Estrogen Receptors

Amalia Miklos; Amelia Tero-Vescan; Daniela-Lucia Muntean

doi:10.2478/abmj-2018-0014

.blurhash-client-img { display: none !important; }

Isoflavonoids − Dual Action on Estrogen Receptors

Acta Biologica Marisiensis

Volume 1 (2018): Issue 2 (December 2018)

By: Amalia Miklos, Amelia Tero-Vescan and Daniela-Lucia Muntean

Open Access

|Jun 2020

Abstract

Isoflavonoids are phytoestrogenic compounds found mainly in plants from the Fabaceae family and also in soy-based foods. Isoflavonoids exhibit (anti)estrogenic effects, acting on estrogen receptors due to the structural similarities with estrogenic hormones (17β-estradiol). The aim of our minireview is to highlight the pharmacokinetic and pharmacodynamic properties of isoflavonoids, in order to sustain the beneficial effects in different pathologies (osteoporosis associated with menopause, breast cancer, prostate cancer, protective cognitive functions) but, at the same time, to aware about the possible adverse effects on long-term administration.

References

1. Ahsan M, Mallick A (2017) The effect of soy isoflavones on the menopause rating scale scoring in perimenopausal and postmenopausal women: a pilot study. J Clin Diag Res. 11(9):13-6.10.7860/JCDR/2017/26034.10654
Search in Google Scholar Back to article
2. Amanat S, Eftekhari MH, Fararouei M, Bagheri Lankarani K, Massoumi SJ (2018) Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: a randomized, controlled trial. Clin Nutr. 37:1210-1215.10.1016/j.clnu.2017.05.028
Search in Google Scholar Back to article
3. Cano A, Garcia-Perez MA, Tarin JJ (2010) Isoflavones and cardiovascular disease. Maturitas 67:219-226.10.1016/j.maturitas.2010.07.015
Search in Google Scholar Back to article
4. Colacurci N, De Franciscis P, Atlante M, Mancino P, Monti M, Volpini G, Benvenuti C (2013) Endometrial, breast and liver safety of soy isoflavones plus lactobacillus sporogenes in post-menopausal women. Gynecol Endocrinol 29:209-212.10.3109/09513590.2012.738724
Search in Google Scholar Back to article
5. Delmanto A, Nahas-Neto J, Traiman P, Uemura G, Pessoa EC, Nahas EA (2013) Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial. Menopause 20(10):1049-54. doi: 10.1097/GME.0b013e3182850270.10.1097/GME.0b013e3182850270
Search in Google Scholar Back to article
6. Dixon RA, Ferreira D (2002) Genistein. Phytochem. 60:205-211.10.1016/S0031-9422(02)00116-4
Search in Google Scholar Back to article
7. Dong JY, Wang P, He K, Qin LQ (2011) Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials. Menopause. 18(11):1256-62. doi: 10.1097/gme.0b013e31821bfa2410.1097/gme.0b013e31821bfa2421712733
Search in Google Scholar Back to article
8. Fáber L, Kováč I, Mitrengová P, Novotný M, Varinská L, Vasilenko T, Kello M, Čoma M, Kuruc T, Petrová K, Miláčková I, Kuczmannová A, Peržeľová V, Mižáková Š, Dosedla E, Sabol F, Luczy J, Nagy M, Majerník J, Koščo M, Mučaji P, Gál P (2018) Genistein improves skin flap viability in rats: a preliminary in vivo and in vitro investigation. Mol. 23:1637; doi:10.3390/molecules23071637.10.3390/molecules23071637610061329973576
Search in Google Scholar Back to article
9. Franke A, Lai J, Halm BM (2014) Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake. Arch Biochem Biophys. 559:24-28.10.1016/j.abb.2014.06.007443925424946051
Search in Google Scholar Back to article
10. Glisic M, Kastrati N, Gonzalez-Jaramillo V, Bramer WM, Ahmadizar F, Chowdhury R, Danser AJ, Roks AJ, Voortman T, Franco OH, Muka T (2018) Associations between phytoestrogens, glucose homeostasis and risk of diabetes in women: A systematic review and meta-analysis. Adv Nutr. 9:726-740.10.1093/advances/nmy048624733930462180
Search in Google Scholar Back to article
11. Grossini E, Farruggio S, Rainaet G, Mary D, Deiro G, Gentilli S (2018) Effects of genistein on differentiation and viability of human visceral adipocytes. Nutr. 10:978; doi:10.3390/nu10080978.10.3390/nu10080978611592830060502
Search in Google Scholar Back to article
12. Gupta C, Prakash D (2014) Phytonutrients as therapeutic agents, J Complement Integr Med. 11(3):151-169.10.1515/jcim-2013-0021
Search in Google Scholar Back to article
13. Harmon AW, Harp JB (2001) Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol. 280(4):C807-13.10.1152/ajpcell.2001.280.4.C807
Search in Google Scholar Back to article
14. Jiang H, Fan J, Cheng L, Hu P, Liu R (2018), The anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells. Onco Thargets Ther. 11:8153-8163.10.2147/OTT.S182239624171530532556
Search in Google Scholar Back to article
15. Kano M, Takayanagi T, Harada K, Sawada S, Ishikawa F (2006) Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J. Nutr. 136:2291-2296.10.1093/jn/136.9.229116920843
Search in Google Scholar Back to article
16. Kolátorová L, Lapčík O, Stárka L (2018) Phytoestrogens and the intestinal microbiome. Physiol. Res. 67(3):S401-S408.10.33549/physiolres.93402230484667
Search in Google Scholar Back to article
17. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA (1997) Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β. Endocrinol. 138(3):863-870.10.1210/endo.138.3.49799048584
Search in Google Scholar Back to article
18. Muhammad A, Madaa SB, Malami I, Forcados GE, Erukainure OL, Sani H, Abubakar IB (2018) Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods. Biomed Pharmacother. 107:571-582.10.1016/j.biopha.2018.08.01830114641
Search in Google Scholar Back to article
19. Nagat C, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S (2014) Soy intake and breast cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn. J. Clin. Oncol. 44:282-295.10.1093/jjco/hyt20324453272
Search in Google Scholar Back to article
20. Pang X, Fu W, Wang J, Kang D, Xu L, Zhao Y, Liu AL, Du GH (2018) Identification of estrogen receptor α antagonists from natural products via in vitro and in silico approaches. Oxid. Med. Cell. Longev. 6040149. doi: 10.1155/2018/60401410.1155/2018/6040149
Search in Google Scholar Back to article
21. Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F (2014) Estrogen Receptors Alpha (ERα) and Beta (ERβ): SubtypeSelective Ligands and Clinical Potential. Steroids. 90:13-29.10.1016/j.steroids.2014.06.012419201024971815
Search in Google Scholar Back to article
22. Reverri EJ, Slupsky CM, Mishchuk DO, Steinberg FM (2017) Metabolomics reveals differences between three daidzein metabolizing phenotypes in adults with cardiometabolic risk factors. Mol Nutr Food Res. 6(1). doi: 10.1002/mnfr.201600132 1150081510.1002/mnfr.20160013227364093
Search in Google Scholar Back to article
23. Rietjens I, Louisse J, Beekmann K (2017) The potential health effects of dietary phytoestrogens. Br J Pharmacol. 174:1263-1280.10.1111/bph.13622542933627723080
Search in Google Scholar Back to article
24. Roozbeh N, Kashef R, Ghazanfarpour M, Kargarfard L, Darvish L, Khadivzadeh T, Dizavandi FR, Afiat M (2018) Overview of the effect of herbal medicines and isoflavones on the treatment of congnitive function. Journal of Menopausal Medicine. 24:113-118.10.6118/jmm.2018.24.2.113612702130202761
Search in Google Scholar Back to article
25. Sathyapalan T, Aye M, Rigby A, Thatcher NJ, Dargham SR, Kilpatrick ES, Atkin SL (2018) Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause. Nutr Metab Cardiovasc Dis. 28(7):691-697.10.1016/j.numecd.2018.03.00729739677
Search in Google Scholar Back to article
26. Sathyapalan T, Dawson AJ, Rigby AS, Thatcher NJ, Kilpatrick ES, Atkin SL (2018) The effect of phytoestrogen on thyroid in subclinical hypothyroidism: randomized, double blind, crossover study. Front Endocrinol. 9:531. doi: 10.3389/fendo.2018.0053110.3389/fendo.2018.00531614162730254609
Search in Google Scholar Back to article
27. Senthilkumar HA, Fata JE, Kennelly EJ (2018) Phytoestrogens: The current state of research emphasizing breast pathophysiology. Phytother Res. 32(9):1707-1719. doi: 10.1002/ptr.611510.1002/ptr.611529876983
Search in Google Scholar Back to article
28. Setchell K (2017) The history and basic science development of soy isoflavones. Menopause. 24(12):1338-50.10.1097/GME.000000000000101829189602
Search in Google Scholar Back to article
29. Simons R, Gruppen H, Toine F, Verbruggen MA, Vincken JP (2012) Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs). Food Funct. 3:810-827.10.1039/c2fo10290k22684228
Search in Google Scholar Back to article
30. Tit DM, Bungau S, Iovan C, Nistor Cseppento DC, Endres L, Sava C, Sabau AM, Furau G, Furau C (2018) Effects of the hormone replacement therapy and of soy isoflavones on bone resorption in postmenopause. J. Clin. Med. 7:297; doi:10.3390/jcm710029710.3390/jcm7100297621015530248918
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/abmj-2018-0014 | Journal eISSN: 2668-5124

Journal RSS Feed

Language: English

Page range: 61 - 67

Submitted on: Nov 4, 2018

Accepted on: Nov 17, 2018

Published on: Jun 8, 2020

Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Related subjects:

© 2020 Amalia Miklos, Amelia Tero-Vescan, Daniela-Lucia Muntean, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 1 (2018): Issue 2 (December 2018)