Skip to main content
Have a personal or library account? Click to login
Effects of lactoferrin and progesterone on the endometriotic lesion in a female rat model Cover

Effects of lactoferrin and progesterone on the endometriotic lesion in a female rat model

Asian Biomedicine
Volume 20 (2026): Issue 3 (June 2026)
By: ,  ,  ,   and    
Open Access
|Jun 2026
Figures & tables

Figures & Tables

Figure 1.

The creation of endometriosis model. The stages of endometriosis model formation (right to left).

Figure 2.

Flow-chart of the study. bLF, bovine lactoferrin; CMC, carboxymethylcellulose; P, progesterone.

Figure 3.

The post-treatment immunohistochemical staninig of endometriotic lesions. Arrow represents each group’s TNF-α, IL-1β, PGR receptors. bLF, bovine lactoferrin; IL, interleukin; PGR, progesterone receptor; TNF-α, tumor necrosis factor-alpha.

Figure 4.

Post-treatment TNF-α, IL-1β, PGR receptor distrbution of endometriotic lesions. bLF, bovine lactoferrine; IL, interleukin; PGR, progesterone receptor; TNF-α, tumor necrosis factor-alpha.

The pre-treatment endometriotic lesion measurements

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
Total volume (mm3)0.02319 ± 0.028370.0643 ± 0.145570.01694 ± 0.013870.03822 ± 0.030760.358
Total ellipsoid volume (mm3)0.01181 ± 0.01490.03078 ± 0.075770.00802 ± 0.006880.019 ± 0.014470.112
Total adhesion score1.875 ± 1.35621.33333 ± 1.224741 ± 11.55556 ± 1.013790.480

The post-treatment PGR, TNF-α, and IL-1β expression in endometriotic tissue

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
TNF-α3 ± 01.67 ± 0.522 ± 01 ± 00.001**
IL-1β2.83 ± 0.412 ± 02.17 ± 0.411.17 ± 0.410.001**
PGR2.83 ± 0.412.17 ± 0.412.17 ± 0.411 ± 00.001**

The differences of pre- and post-treatment measurements

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
Total volume (mm3)−0.01 ± 0.04−0.05 ± 0.14−0.01 ± 0.02−0.03 ± 0.030.653
Total ellipsoid volume (mm3)−0.01 ± 0.02−0.02 ± 0.08−0.01 ± 0.01−0.01 ± 0.020.413
Total adhesion score−0.13 ± 2.640.56 ± 2.010.78 ± 1.480.56 ± 1.010.890

The post-treatment TAS and TOS values

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
TAS (mmol trolox equiv./kg wet weight)30.73 ± 16.0723.14 ± 7.6322.75 ± 9.6621.5 ± 2.110.623
TOS (µmol H2O2 equiv./gprot)81.45 ± 16.6776.12 ± 17.982.39 ± 27.1285.54 ± 11.690.318

The post treatment blood progesterone and LF values

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
Progesterone (ng/mL)2.84 ± 1.943.83 ± 3.292.98 ± 1.823.19 ± 1.280.0627
LF (µ/mL)35.54 ± 3.8337.01 ± 5.827.84 ± 1.4238.56 ± 5.750.001**

The post-treatment endometriotic lesion measurements

Control (n = 10) (mean ± sd)bLF (n = 10) (mean ± sd)Progesteron (n = 10) (mean ± sd)Mixed (n = 10) (mean ± sd)P
Total volume (mm3)0.01 ± 0.030.02 ± 0.010 ± 00.01 ± 0.010.225
Total ellipsoid volume (mm3)0.01 ± 0.010.01 ± 0.010 ± 00.01 ± 0.010.265
Total adhesion score1.75 ± 1.391.89 ± 1.051.78 ± 1.22.11 ± 0.930.959
DOI: https://doi.org/10.2478/abm-2026-0019 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Journal RSS Feed
Language: English
Page range: 161 - 169
Published on: Jun 30, 2026
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Keywords:
animal models,
endometriosis,
lactoferrin,
oxidative stress,
progesterone
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Medicine,
Basic medical science,
Basic medical science, other,
Medicine,
Assistive professions, nursing

© 2026 İrem Şenyuva, Duygu Baki Acar, Hasan Hüseyin Demirel Bayat, Funda Karabağ, Ece Tunç, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 20 (2026): Issue 3 (June 2026)
Previous article
Next article