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Gut–testis axis: how microbiota influence male reproductive health Cover

Gut–testis axis: how microbiota influence male reproductive health

Open Access
|Jun 2026

Figures & Tables

Figure 1.

Influence of intestinal microorganisms on testicular function.

Figure 2.

Gut microbiota imbalance leads to testicular inflammation and BTB damage. BTB, blood–testis barrier; TLR, toll-like receptor.

Summarizes the nutrients produced by gut microbiota that influence the male reproductive system

Main bacteriaNutrientFunction in the male reproductive system
Escherichia coli Clostridia [26]Vitamins AEncourages spermatogonial stem cells to differentiate into sperm
Bacteroides fragilis [26]Vitamins KResistance against the inflammatory response
Promotes serum testosterone and the blood–testis barrier
Lactobacillus Bifidobacterium Acidobacillus [27]Folic acidEncouraging germ cell differentiation
Anti-inflammatory and antioxidant
Bifidobacteria Lactobacillus [28]CalciumEnhances sperm motility and capacitation
Initiates the acrosome reaction Signal transduction in germ cells
DOI: https://doi.org/10.2478/abm-2026-0017 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 149 - 154
Published on: Jun 30, 2026
In partnership with: Paradigm Publishing Services

© 2026 Ruiyang Hu, Jingxing Wu, Nianben Chen, Wenjun Ma, Qinglin Hu, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.