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Can transcutaneous bilirubin levels obtained from covered skin replace serum bilirubin measurement in neonates undergoing phototherapy? Cover

Can transcutaneous bilirubin levels obtained from covered skin replace serum bilirubin measurement in neonates undergoing phototherapy?

Open Access
|Aug 2025

Figures & Tables

Figure 1.

TcB measurements after PT. (A) TcB measurement at the exposed area and (B) TcB measurement under the covered shield. The neonate’s face is shown with full, explicit written informed consent obtained from the parents for publication of this identifiable image. The parents were informed about the nature, purpose, and extent of the publication, including digital distribution. PT, phototherapy; TcB, transcutaneous bilirubin.

Table 1.

Epidemiological characteristics of the neonates receiving PT for hyperbilirubinemia

CharacteristicsN (%)
Gestational age (weeks), median (range)38 (31–42)
Birth weight (g), mean ± SD3020 ± 556
Sex
  Female36 (51.4)
  Male34 (48.6)
Maternal age (years), mean ± SD26.3 ± 5.7
Maternal disease status
  Yes8 (11.4)
  No60 (88.6)
Mode of delivery
  NSVD51 (72.9)
  C/S19 (27.1)
Age at admission (days), median (range)2 (1–13)
Length of stay (days), median (range)3 (2–27)
Blood incompatibility
  None25 (35.8)
  ABO incompatibility41 (58.6)
  Rh incompatibility3 (4.2)
  ABO + Rh incompatibility1 (1.4)
DC test
  Negative47 (67.2)
  Positive23 (32.8)
Pathological weight loss
  Yes10 (14.3)
  No60 (85.7)
Cephalic hematoma
  Yes2 (2.9)
  No68 (97.1)

[i] C/S, Cesarean section; DC, direct Coombs; NSVD, normal spontaneous vaginal delivery; PT, phototherapy; SD, standard deviation.

Table 2.

Comparison of TSB and TcB levels from covered and exposed skin measured before, during, and after PT

Before PTAt 24th hour of PT8 h after discontinuation of PT
TSB11.91 ± 4.487.67 ± 2.347.90 ± 2.09
Covered skin TcB11.11 ± 3.017.07 ± 2.258.61 ± 2.39
Exposed skin TcB11.14 ± 3.114.13 ± 1.886.85 ± 2.44

[i] PT, phototherapy; SD, standard deviation; TcB, transcutaneous bilirubin; TSB, total serum bilirubin.

Table 3.

Correlation between TSB values and TcB values measured from covered and exposed skin

Before PT ICC (95% CI)After 24 h of PT ICC (95% CI)8 h after PT ICC (95% CI)
TSB vs. exposed skin TcB0.667 (0.513–0.780)0.229 (0.092–0.544)0.432 (0.200–0.613)
TSB vs. covered skin TcB0.665 (0.508–0.778)0.520 (0.326–0.672)0.537 (0.339–0.687)
Exposed vs. covered skin TcB0.828 (0.737–0.890)<0.245 (0.095–0.542)0.557 (0.056–0.784)

[i] CI, confidence interval; ICC, intraclass correlation coefficient; PT, phototherapy; TcB, transcutaneous bilirubin; TSB, total serum bilirubin.

Figure 2.

Correlation between TSB and covered skin TcB (A) and exposed skin TcB (B) measurement after 24 h of PT. Correlation between TSB and covered skin TcB (C) and exposed skin TcB (D) measurements 8 h after discontinuing PT. The Bland-Altman plot shows the average of the two methods on the X-axis and the absolute difference between the two methods on the Y-axis. PT, phototherapy; TcB, transcutaneous bilirubin; TSB, total serum bilirubin.

DOI: https://doi.org/10.2478/abm-2025-0025 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 183 - 189
Published on: Aug 31, 2025
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services

© 2025 M. Fatih Ozden, Dilek Kahvecioglu, Melda Tas, Aslihan Kose Cetinkaya, Ahmet Oktem, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.