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Comparison of intravenous immunoglobulin and plasma exchange in hospital-acquired infections of autoimmune encephalitis in a tertiary care center Cover

Comparison of intravenous immunoglobulin and plasma exchange in hospital-acquired infections of autoimmune encephalitis in a tertiary care center

Open Access
|Jun 2025

Figures & Tables

Figure 1.

Flow diagram of inclusion and exclusion of the study. AIE, autoimmune encephalitis; IVIG, intravenous immunoglobulin; IVMP, intravenous pulse methylprednisolone; KCMH, King Chulalongkorn Memorial Hospital; PLEX, plasma exchange.
Flow diagram of inclusion and exclusion of the study. AIE, autoimmune encephalitis; IVIG, intravenous immunoglobulin; IVMP, intravenous pulse methylprednisolone; KCMH, King Chulalongkorn Memorial Hospital; PLEX, plasma exchange.

Figure 2.

Cumulative incidence of HAIs of patients hospitalized due to AIE, categorized by those who received PLEX and IVIG. AIE, autoimmune encephalitis; HAIs, hospital-acquired infections; IVIG, intravenous immunoglobulin; PLEX, plasma exchange.
Cumulative incidence of HAIs of patients hospitalized due to AIE, categorized by those who received PLEX and IVIG. AIE, autoimmune encephalitis; HAIs, hospital-acquired infections; IVIG, intravenous immunoglobulin; PLEX, plasma exchange.

Occurrence of infectious complication during hospitalization, duration of hospitalization, degree of disability at discharge, and total direct cost of hospitalization of patients hospitalized due to AIE

Total (n = 44) n (%)IVIG group (n = 34) n (%)PLEX group (n = 10) n (%)P
HAI10 (22.7)5 (14.7)5 (50.0)0.03*
Duration of hospitalization (d) 0.05
  ≤711 (25.0)11 (32.5)0 (0)
  8–3024 (54.5)18 (52.9)6 (60)
  >309 (20.5)5 (14.7)4 (40)
  Median (IQR)16.5 (7.5–28.0)12.0 (6.0–23.0)25.0 (21.0–49.0)0.01*
mRS at discharge 0.31
  01 (2.3)1 (2.9)0 (0)
  120 (45.5)17 (50.0)3 (30.0)
  219 (43.2)14 (41.2)5 (50.0)
  31 (2.3)1 (2.9)0 (0)
  51 (2.3)0 (0)1 (10.0)
  62 (4.5)1 (2.9)1 (10.0)
  Median (IQR)2.0 (1.0–2.0)1.0 (1.0–2.0)2.0 (1.0–2.0)0.12
Median (IQR) of differences in mRS between admission and discharge−1.0 (−2.0 to −1.0)−1.0 (−2.0 to −1.0)−1.0 (−2.0 to −1.0)0.57
Median (IQR) total direct cost of hospitalization, USD8,063.9 (6,378.9–11,149.3)8,322.9 (6,698.8–10,402.2)7,024.8 (6,206.1–12,838.0)0.54

Baseline characteristics of 44 patients hospitalized due to AIE at the King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, between January 2015 and December 2019

Total (n = 44) n (%)IVIG group (n = 34) n (%)PLEX group (n = 10) n (%)P
Median (IQR) age, years44.5 (28.0–62.5)50.5 (28.0–70.0)37.5 (24.0–55.0)0.14
Gender 0.70
  Male13 (29.5)11 (32.4)2 (20.0)
  Female31 (70.5)23 (67.7)8 (80.0)
mRS at admission 0.43
Median (IQR)3.0 (2.0–3.0)3.0 (2.0–3.0)3.0 (3.0–3.0)0.65
  214 (31.8)12 (35.3)2 (20.0)
  327 (61.4)19 (55.9)8 (80.0)
  43 (6.8)3 (8.8)0 (0)
Cancer6 (13.6)5 (14.7)1 (10.0)>0.99
Diabetes mellitus6 (13.6)5 (14.7)1 (10.0)>0.99
Cirrhosis1 (2.3)1 (2.9)0 (0)0.77
Currently using immunosuppressive drugs3 (6.8)3 (8.8)0 (0)>0.99
Place of admission 0.13
  ICU3 (6.8)1 (2.9)2 (20.0)
  Regular ward41 (93.2)33 (97.1)8 (80.0)
Type of antibodies 0.61
  Intracellular14 (31.8)12 (35.3)2 (20.0)
  Neuronal surface24 (54.6)18 (52.9)6 (60.0)
  Ab negative6 (13.6)4 (11.8)2 (20.0)
DOI: https://doi.org/10.2478/abm-2025-0018 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 147 - 153
Published on: Jun 30, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year

© 2025 Totsapol Surawattanawong, Akarin Hiransuthikul, Panthicha Katasrila, Thiravat Hemachudha, Abhinbhen W. Saraya, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.