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Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study Cover

Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study

Open Access
|Oct 2023

Figures & Tables

Figure 1.

CD68 immune stained images of normotensive (A, B) and HELLP (C, D). Arrowhead: Hoffbauer cells Bar: 50 μm in (A) and (C), 20 μm in (B) and (D). HELLP, hemolysis, elevated liver enzymes, low platelet count.
CD68 immune stained images of normotensive (A, B) and HELLP (C, D). Arrowhead: Hoffbauer cells Bar: 50 μm in (A) and (C), 20 μm in (B) and (D). HELLP, hemolysis, elevated liver enzymes, low platelet count.

Figure 2.

The percentage of Hoffbauer cells per villus in the normotensive and HELLP group placentas. *: stands for statistical difference between groups (*P < 0.001). HELLP, hemolysis, elevated liver enzymes, low platelet count.
The percentage of Hoffbauer cells per villus in the normotensive and HELLP group placentas. *: stands for statistical difference between groups (*P < 0.001). HELLP, hemolysis, elevated liver enzymes, low platelet count.

Figure 3.

Ultrastrucutural placenta section of HELLP group. Degenerative structure (blue arrow) in cell surface membrane, intracytoplasmic edema, and degenerative vacuoles (yellow arrow) in syncytiotrophoblast(lead nitrate-uranyl acetate, Bar: 20,000 nm). HELLP, hemolysis, elevated liver enzymes, low platelet count.
Ultrastrucutural placenta section of HELLP group. Degenerative structure (blue arrow) in cell surface membrane, intracytoplasmic edema, and degenerative vacuoles (yellow arrow) in syncytiotrophoblast(lead nitrate-uranyl acetate, Bar: 20,000 nm). HELLP, hemolysis, elevated liver enzymes, low platelet count.

Clinical and biochemical parameters of normotensive and HELLP patients

Clinical featuresNormotensive Median (min–max)HELLP Median (min–max)
Age32 (29–35)32 (30–37)
Gravida2 (0–4)4 (2–5)
Parity1 (0–3)5 (2–7)
Gestation week38 (37–39)38 (38–40)
Systolic BP95 (88–105)205 (153–233)
Diastolic BP75 (65–90)98 (90–111)
Hemoglobin13 (12–14)12 (8–13)
Platelet265 (135–355)154 (133–274)
Glucose88 (70–98)92 (83–110)
Urea15 (11–18)34 (23–52)
Creatinine0.45 (0.40–0.52)0.59 (0.51–0.70)
ALT10 (6–18)14 (9–60)
AST19 (10–36)26 (20–333)
24 h-urine protein157 (110–195)1,105 (889–1,245)
DOI: https://doi.org/10.2478/abm-2023-0065 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 238 - 243
Published on: Oct 26, 2023
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year

© 2023 Yusuf Nergiz, Engin Deveci, Erdal Sak, Sıddık Evsen, Selçuk Tunik, Şebnem Nergiz, Fırat Aşır, Uğur Şeker, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.