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Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review Cover

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

Asian Biomedicine
Volume 17 (2023): Issue 2 (April 2023)
By: Jiansheng Zheng and  Tang Zhu  
Open Access
|Sep 2023

Figures & Tables

Figure 1.

Study selection flow diagram describing the screening process. FUT3, fucosyltransferase 3 gene; IBD, inflammatory bowel disease.
Study selection flow diagram describing the screening process. FUT3, fucosyltransferase 3 gene; IBD, inflammatory bowel disease.

Figure 2.

Forest plots of meta-analysis of the genotypes of rs3745635 and IBD. The odds ratios and 95% CIs of the 1712 patients with IBD with GA + AA vs GG rs3745635 genotype and the 1903 controls from 5 articles (A), the 1654 patients with IBD with GG + GA vs AA rs3745635 genotype and the 1843 controls from 4 articles (B), the 1031 patients with IBD with GG vs AA rs3745635 genotype and the 1400 controls from 4 articles (C), and the 3309 patients with IBD with A vs G rs3745635 genotype and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotypes of rs3745635 and IBD. The odds ratios and 95% CIs of the 1712 patients with IBD with GA + AA vs GG rs3745635 genotype and the 1903 controls from 5 articles (A), the 1654 patients with IBD with GG + GA vs AA rs3745635 genotype and the 1843 controls from 4 articles (B), the 1031 patients with IBD with GG vs AA rs3745635 genotype and the 1400 controls from 4 articles (C), and the 3309 patients with IBD with A vs G rs3745635 genotype and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Figure 3.

Forest plots of meta-analysis of the genotypes of rs3894326 and IBD. The odds ratios and 95% CIs of 1712 patients with IBD with TA +AA vs TT genotype of the rs3894326 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TA vs AA genotype of the rs3894326 gene and the 1843 controls from 4 articles (B), the 1375 cases of IBD with TT vs AA genotype of the rs3894326 gene and the 1522 controls from 4 articles (C), and the 3309 patients with IBD with A vs T genotype of the rs3894326 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotypes of rs3894326 and IBD. The odds ratios and 95% CIs of 1712 patients with IBD with TA +AA vs TT genotype of the rs3894326 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TA vs AA genotype of the rs3894326 gene and the 1843 controls from 4 articles (B), the 1375 cases of IBD with TT vs AA genotype of the rs3894326 gene and the 1522 controls from 4 articles (C), and the 3309 patients with IBD with A vs T genotype of the rs3894326 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Figure 4.

Forest plots of meta-analysis of the genotype of the rs28362459 gene and IBD. The odds ratios and 95% CIs of the 1712 cases of IBD with TG + GG vs TT genotype of the rs28362459 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TG vs GG genotype of the rs28362459 gene and the 1843 controls from 4 articles (B), the 1046 patients with IBD with TT vs GG genotype of the rs28362459 gene and the 1157 controls from 4 articles (C), and the 3309 patients with IBD with G vs T genotype of the rs28362459 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotype of the rs28362459 gene and IBD. The odds ratios and 95% CIs of the 1712 cases of IBD with TG + GG vs TT genotype of the rs28362459 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TG vs GG genotype of the rs28362459 gene and the 1843 controls from 4 articles (B), the 1046 patients with IBD with TT vs GG genotype of the rs28362459 gene and the 1157 controls from 4 articles (C), and the 3309 patients with IBD with G vs T genotype of the rs28362459 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Meta-analysis of the association between FUT3 and IBD

GeneGenetic modelHeterogeneityConsolidated resultsEgger test
χ2PI2 (%)OR (95% CI)ZPtP
rs3745635GG + GA vs AA0.640.8901.93 (1.23–3.05)2.840.0041.650.242
rs3745635GA + AA vs GG5.610.23290.84 (0.72–0.97)2.360.020.870.447
rs3745635GG vs AA2.450.4802.38 (1.52–3.74)3.760.0000.150.897
rs3745635A vs G2.090.5500.84 (0.73–0.96)2.600.0093.550.071
rs3894326TA + AA vs TT1.790.7701.03 (0.87–1.23)0.390.700.010.990
rs3894326TT + TA vs AA1.170.7601.19 (0.56–2.51)0.460.651.310.321
rs3894326TT vs AA1.240.7401.19 (0.56–2.51)0.450.651.320.317
rs3894326A vs T1.960.5801.02 (0.86–1.20)0.220.830.690.563
rs28362459TG + GG vs TT2.250.6900.98 (0.85–1.12)0.350.730.680.546
rs28362459TT + TG vs GG0.100.9901.20 (0.90–1.61)1.250.211.000.424
rs28362459TT vs GG0.260.9701.21 (0.90–1.62)1.250.210.370.746
rs28362459G vs T1.670.6400.96 (0.86–1.07)0.780.440.340.764

Basic characteristics of the included manuscripts

ArticleNationDiseaseIBDControlsGene
Age (years)M:FnAge (years)M:Fn
Hu et al., 2014 [26]ChinaCD36.24 ± 14.52121:15227336.76 ± 15.62223:256479rs3745635, rs3894326, rs28362459
Xu et al., 2014 [27]ChinaUC42.25 ± 13.28130:10323340.96 ± 15.42157:135292rs3745635, rs3894326, rs28362459
Guo et al., 2015 [28]ChinaUC41.56 ± 14.45224:16538941.24 ± 16.01263:229492rs3745635, rs3894326, rs28362459
ChinaCD39.49 ± 16.51153:121274
Hu et al., 2016 [29]ChinaUC40.23 ± 15.32201:28448541.09 ± 17.11261:319580rs3745635, rs3894326, rs28362459
Chen et al., 2018 [30]ChinaUC36–5931:275834–6034:2660rs3745635, rs3894326, rs28362459

Quality evaluation of the included articles with NOS

ArticleItem 1Item 2Item 3Item 4Item 5Item 6Item 7Item 8Score
Hu et al., 2014 [26]YesUnclearYesYesAge, genderYesYesYes8
Xu et al., 2014 [27]YesUnclearYesYesAge, genderYesYesYes8
Guo et al., 2015 [28]YesUnclearYesYesAge, genderYesYesYes8
Hu et al., 2016 [29]YesUnclearYesYesAge, genderYesYesYes8
Chen et al., 2018 [30]YesUnclearYesYesAge, genderYesYesYes8
DOI: https://doi.org/10.2478/abm-2023-0044 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 45 - 54
Published on: Sep 17, 2023
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Publication frequency: 6 issues per year
Keywords:
fucosyltransferase 3 (),
genotype,
inflammatory bowel disease (IBD),
meta-analysis,
polymorphism
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2023 Jiansheng Zheng, Tang Zhu, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.

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