Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia Cover

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Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia

Asian Biomedicine

Volume 16 (2022): Issue 3 (June 2022)

By: Gulen Burakgazi , Gul Ilhan , Oguzhan Ozcan and Emre Dirican

Open Access

|Jun 2022

Figures & Tables

SWV measurement in a healthy patient in the control group generated by the acoustic radiation force impulse. SWV (1.16 m/s) reflects tissue elasticity, which can be calculated using Young's modulus. Thus, shear wave elasticity can be used to evaluate tissue stiffness, both quantitatively and objectively. Parenchymal stiffness measured in the ROI on the left lobe was 4.01 kPa. ROI, region of interest; SWV, shear wave velocity.

Shear wave velocity measurement in a patient with SCA. Parenchymal stiffness measured in the ROI on the left lobe was 11.45 kPa. ROI, region of interest; SCA, sickle cell anemia.

Correlations of serum levels of thyroid function molecules and antibodies with thyroid stiffness left (gray bars) and right (white bars). Significant correlations were found between serum levels of Tg fT3 and left (P = 0.008 and P = 0.024, respectively) and right stiffness (P = 0.020 and P = 0.007, respectively). Other variables, TgAb, fT4, TSH, and TPOAb, were not significantly correlated. fT3, free triiodothyronine; fT4, free thyroxin; Tg, thyroglobulin; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone.

ROC curve of thyroid gland SWE in patients with SCA. The cutoff for the RL elasticity (blue line) is 7.31 kPa (AUC 0.57, P = 0.32), and the cutoff value for the LL elasticity (green line) is 8.06 kPa (AUC 0.68, P = 0.011). Reference line is tan. AUC, area under the curve; LL, left lobe; RL, right lobe; ROC, receiver operating characteristic; SCA, sickle cell anemia; SWE, shear wave elastography.

Demographic, blood, and serum biochemical variables

		SCA (n = 36)		Healthy controls (n = 33)		P

		Mean ± SD	Median	Mean ± SD	Median
Age (years)		31.3 ± 8.2	30.5	32.6 ± 5.8	32.0	0.46
Sex, n (%)	Female	18 (52.9)		16 (47.1)		0.90
Sex, n (%)	Male	18 (51.4)		17 (48.6)
BMI (kg/m²)		21.30 ± 1.83	22.00	22.78 ± 2.25	23.00	0.004^*
Volume (mL)		3.91 ± 1.39	3.45	5.25 ± 1.84	4.80	0.001^*
Left lobe		3.25 ± 1.21	2.90	4.26 ± 1.27	4.20	0.001^*
Isthmus (mm)		3.06 ± 1.24	2.95	3.29 ± 0.79	3.00	0.35
Thyroid stiffness (kPa)
Right lobe		7.39 ± 3.30	7.57	6.39 ± 1.82	6.34	0.13
Left lobe		8.20 ± 2.89	8.43	6.41 ± 1.80	6.45	0.003^*
fT3 (pmol/L)		2.92 ± 0.61	2.91	3.27 ± 0.44	3.16	0.004^*
fT4 (ng/dL)		1.29 ± 0.16	1.29	1.30 ± 0.16	1.32	0.75
TSH (mU/L)		1.82 ± 0.80	1.68	1.44 ± 0.55	1.30	0.028^*
Tg (ng/mL)		5.81 ± 3.04	5.59	13.55 ± 7.76	10.55	0.001^*
TgAb (IU/mL)		21.36 ± 6.04	20.00	21.95 ± 10.42	20.00	0.47
TPOAb (IU/mL)		23.41 ± 16.15	20.00	20.00 ± 0.00	20.00	0.82
Ferritin (ng/mL)		656.3 ± 622.6	426.6
Hb (g/dL)		8.88 ± 1.75	8.75
Hct (%)		26.11 ± 5.12	26.35
CRP (mg/L)		10.08 ± 7.94	7.18

DOI: https://doi.org/10.2478/abm-2022-0017 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415

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Language: English

Page range: 137 - 143

Published on: Jun 30, 2022

Published by: Chulalongkorn University

In partnership with: Paradigm Publishing Services

Publication frequency: 6 issues per year

Keywords:

anemia, sickle cell,

anti-thyroid autoantibodies,

elasticity imaging techniques,

Related subjects:

Assistive professions, nursing,

Basic medical science,

Basic medical science, other,

Clinical medicine,

Clinical medicine, other

© 2022 Gulen Burakgazi, Gul Ilhan, Oguzhan Ozcan, Emre Dirican, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.

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