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PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer Cover

PIWI-interacting RNA (piRNA): a narrative review of its biogenesis, function, and emerging role in lung cancer

Asian Biomedicine
Volume 16 (2022): Issue 1 (February 2022)
By: ,   and    
Open Access
|Feb 2022
Figures & tables

Figures & Tables

Figure 1

Early discoveries related to PIWI proteins and piRNA. piRNA, PIWI-interacting RNA; PIWI, P-element induced wimpy testis protein.

Table 1

Important discoveries of PIWI/piRNA expression in various cancers†

YearPIWI/piRNAExpressionCancer typeRole
2005PIWIL2UpregulatedTesticular seminomaInhibition of apoptosis and promotion of proliferation via Stat3/Bcl-XL signaling pathway [18]
2006PIWIL1UpregulatedHuman gastric cancerCell proliferation [19]
2007PIWIL1UpregulatedSoft tissue sarcomaStem cell proliferation [20]
2008PIWIL1Up/down-regulatedAdenocarcinomaPoor prognosis and death [21]
2009PIWIL1Presence in cytoplasmEsophageal squamous cell carcinomaPoor prognosis [22]
2010PIWIL2VariedCervical neoplasiaBiomarker [23]
2010PIWIL2UpregulatedHuman breast cancersBiomarker [24]
2011PIWIL1UpregulatedGliomaTumor progression, poor outcome, and biomarker [25]
2011piR-651UpregulatedGastric, colon, lung, and breast cancerIncreases cell proliferation [26]
2011PIWIL1UpregulatedColorectal cancerLeads to poor overall survival, biomarker [27]
2012piR-823DownregulatedGastric cancerIncreases cell proliferation [28]
2012PIWIL2UpregulatedColon cancerMetastasis [29]
2013PIWIUpregulatedStage III epithelial ovarian cancerPromotes metastasis, biomarker [30]
2013piR-932UpregulatedBreast cancerPositive regulator of breast cancer stem cells [31]
2014PIWIL1UpregulatedHuman breast cancerCell proliferation [32]
2014piRNA-823UpregulatedMultiple myelomaRegulates angiogenesis [33]
2014PIWIL1 and PIWIL4VariedRenal cell carcinomaRelated to clinicopathological parameters [34]
2014PIWIL1UpregulatedCervical cancerPromotes chemoresistance [35]
2014PIWIL1UpregulatedHepatocellular carcinomaReduces proliferation and migration [36]
2015piRNA-DQ594040DownregulatedBladder cancerPromotes cell proliferation, colony formation and functions against apoptosis [37]
2015piR-021285UpregulatedBreast cancerEpigenetic remodeling [38]
2015PIWIL2UpregulatedProstate cancerMetastasis [39]
2015piR-017061DownregulatedPancreatic cancerAssociated with diseased condition [40]
2015piR-015551DownregulatedColorectal cancerAssociated with long ncRNA expression [41]
2015PIWIL1DownregulatedChronic myeloid leukemiaInduces growth and metastasis [42]
2015PIWIL2UpregulatedCholangiocarcinomaInvolved in shorter survival span and metastasis [43]
2015piR-57125DownregulatedRenal cell carcinomaAssociated with tumor recurrence and metastasis, prognostic biomarker [44]
piR-30924Upregulated
piR-38756Upregulated
2015PIWIL1UpregulatedType 1 endometrial cancerTumor progression by downregulating PTEN [45]
2015PIWIL2DownregulatedBladder cancerRelated to disease specific and progression free survival [46]
2016PIWIL4UpregulatedBreast cancerMetastasis, antiapoptotic activity and proliferation[47]
2016FR140858Differentially expressedHead and neck squamous cell carcinomaCorrelated to human papillomavirus infection [48]
2016piR-598UpregulatedGliomaInduces growth and proliferation [49]
2017PIWIL3UpregulatedMelanomaInduces metastasis [50]
2017PIWIL4UpregulatedRetinoblastomaInduces proliferation [51]
2018piR-5937VariedColon cancerBiomarker [52]
piR-28876
2018piR-8041DownregulatedGlioblastomaRelated to tumor growth [53]
2018PIWIL1UpregulatedGastric cancerMetastasis [54]
2018PIWIL1 and PIWIL2VariedMuscle invasive urothelial bladder cancerCorrelation with clinical factors, biomarkers [55]
2018PIWIL4UpregulatedHuman breast cancerCell motility [56]
2019piR-823UpregulatedMultiple myelomaTumor progression [57]
2019piR-39980UpregulatedNeuroblastomaTumor progression and drug resistance [58]
2019piR-36712DownregulatedBreast cancerChemoresistance and tumor progression [59]
2020piR-004987UpregulatedLung cancerCorrelated with lung cancer from sputum as compared with normal [60]
piR-020809Upregulated
piR-023338Downregulated
piR-011186Downregulated
2021piR-hsa-211106DownregulatedLung cancerChemoresistance and tumor progression [61]
2021piR-1008UpregulatedLung cancer
piR-28231UpregulatedLung cancer
piR-11256UpregulatedLung cancer
piR-30636UpregulatedLung cancer
piR-24143UpregulatedLung cancerBiomarker lung cancer [62]
piR-6842UpregulatedLung cancer
piR-8757UpregulatedLung cancer
piR-15572UpregulatedLung cancer
piR-5444UpregulatedLung cancer and serum exosome
piR-26925Upregulated

† Lung cancer until 2021 and other cancers until 2019. PIWI, PIWI protein (human); piRNA, Piwi protein-interacting RNA; PIWIL1, PIWI-like 1 protein (human) or HIWI protein (human); PIWIL2, HILI protein (human); PIWIL3, HIWI3 protein (human); and PIWIL4, HIWI2 protein (human); ncRNA, non-coding RNA.

Figure 2

Representation of how the present findings for PIWI proteins or piRNA integrate with the emerging hallmarks of cancer in the case of lung cancer. Turquoise represents positively regulated with the hallmark, while red represents negatively regulated with the hallmark. piRNA, PIWI-interacting RNA; P-element induced wimpy testis protein.

DOI: https://doi.org/10.2478/abm-2022-0002 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
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Language: English
Page range: 3 - 14
Published on: Feb 28, 2022
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services
Keywords:
PIWI protein,
Drosophila,
RNA,
small interfering,
Argonaute proteins,
lung neoplasms,
epigenetic repression
Related subjects:
Medicine,
Assistive professions, nursing,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other

© 2022 Pritha Mukherjee, Shamee Bhattacharjee, Deba Prasad Mandal, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 16 (2022): Issue 1 (February 2022)
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