Cytogenetic Damage in Turkish Coke Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 Gene Polymorphisms

Ahmet Oguz Ada; Canan Demiroglu; Meltem Yilmazer; Halit Sinan Suzen; Ali Eba Demirbag; Sibel Efe; Yilmaz Alemdar; Mumtaz Iscan; Sema Burgaz

doi:10.2478/10004-1254-64-2013-2328

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Cytogenetic Damage in Turkish Coke Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 Gene Polymorphisms

Archives of Industrial Hygiene and Toxicology

Volume 64 (2013): Issue 3 (September 2013)

By: Ahmet Oguz Ada, Canan Demiroglu, Meltem Yilmazer, Halit Sinan Suzen, Ali Eba Demirbag, Sibel Efe, Yilmaz Alemdar, Mumtaz Iscan and Sema Burgaz

Open Access

|Oct 2013

Abstract

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasinblocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample

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Articles in this issue

DOI: https://doi.org/10.2478/10004-1254-64-2013-2328 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254

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Language: English, Croatian, Slovenian

Page range: 359 - 369

Published on: Oct 1, 2013

Published by: Institute for Medical Research and Occupational Health

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

chromosomal aberrations,

biomarkers,

micronuclei,

occupational exposure

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2013 Ahmet Oguz Ada, Canan Demiroglu, Meltem Yilmazer, Halit Sinan Suzen, Ali Eba Demirbag, Sibel Efe, Yilmaz Alemdar, Mumtaz Iscan, Sema Burgaz, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 64 (2013): Issue 3 (September 2013)