Have a personal or library account? Click to login
Analysis of Protein Adducts as Biomarkers of Short-Term Exposure to Ethylene Oxide and Results of Follow-Up Biomonitoring Cover

Analysis of Protein Adducts as Biomarkers of Short-Term Exposure to Ethylene Oxide and Results of Follow-Up Biomonitoring

Archives of Industrial Hygiene and Toxicology
Volume 63 (2012): Issue 2 (June 2012)
By: Michael Bader,  Wolfgang Will,  Gunild Frey and  Michael Nasterlack  
Open Access
|Jun 2012

References

  1. World Health Organization (WHO). Ethylene oxide. Environmental Health Criteria 55. Geneva: World Health Organization; 1985.
    Search in Google Scholar
  2. Deutsche Forschungsgemeinschaft (DFG). Ethylene oxide. In: Henschler D, editor. Occupational toxicants. Critical data evaluation for MAK values and classification of carcinogens. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Vol. 5. Weinheim: VCH Verlagsgesellschaft; 1993. p. 182-92.
    Search in Google Scholar
  3. International Agency for Research on Cancer (IARC). Monographs on the evaluation of carcinogenic risks to humans. 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Vol. 97. Lyon: IARC; 2008.
    Search in Google Scholar
  4. Angerer J, Bader M, Krämer A. Ambient and biochemical effect monitoring of workers exposed to ethylene oxide. Int Arch Occup Environ Health 1998;71:14-8.10.1007/s004200050244
    Search in Google Scholar
  5. Rosenberger W, Graubner G, Wrbitzky R, Bader M. [Untersuchungen zur Freisetzung von Ethylenoxid aus gassterilisierten neurochirurgischen Implantaten, in German]. Presentation on the occasion of the 49. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin (DGAUM). In: Kraus Th, Gube M, editors. 49. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin (DGAUM), 2009. Documentation on CD-ROM.
    Search in Google Scholar
  6. Gemeinsames Ministerialblatt (GMBl). [Bek. v. 2.8.10, Bekanntmachung von Empfehlungen für Biomonitoring bei Tätigkeiten mit krebserzeugenden Gefahrstoffen, in German]. GMBI 2010;62:1257-60.
    Search in Google Scholar
  7. Gemeinsames Ministerialblatt (GMBI). [TRGS 513 (Technische Regel für Gefahrstoffe) Tätigkeiten an Sterilisatoren mit Ethylenoxid und Formaldehyd, in German]. GMBI 2011;49-51:993-1018.
    Search in Google Scholar
  8. Norpoth K, Bolt HM. Ethylene oxide [BAT Value Documentation, 1995]. The MAK-Collection for Occupational Health and Safety [displayed 17 May 2012]. Available at http://onlinelibrary.wiley.com/doi/10.1002/3527600418.bb7521e0002/pdf
    Search in Google Scholar
  9. Bolt H. Ethylene oxide, Addendum [BAT Value Documentation, 2010]. The MAK-Collection for Occupational Health and Safety [displayed 17 May 2012]. Available at http://onlinelibrary.wiley.com/doi/10.1002/3527600418.bb7521e0005/pdf
    Search in Google Scholar
  10. Törnqvist M, Mowrer J, Jensen S, Ehrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal Biochem 1986;154:255-66.10.1016/0003-2697(86)90524-5
    Search in Google Scholar
  11. Lewalter J. N-alkylvaline levels in globin as a new type of biomarker in risk assessment of alkylating agents. Int Arch Occup Environ Health 1996;68:519-30.10.1007/BF00377881
    Search in Google Scholar
  12. Törnqvist M, Fred C, Haglund J, Helleberg B, Paulsson B, Rydberg P. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B Analyt Technol Biomed Life Sci 2002;778:279-308.10.1016/S1570-0232(02)00172-1
    Search in Google Scholar
  13. Deutsche Forschungsgemeinschaft (DFG). List of MAK and BAT values 2011. Maximum Concentrations and Biological Tolerance Values at the Workplace. Report 47. Weinheim: Wiley-VCH; 2011.10.1002/9783527666034
    Search in Google Scholar
  14. Bailey E, Brooks AGF, Dollery CT, Farmer PB, Passingham BJ, Sleightholm M, Yates DW. Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake. Arch Toxicol 1988;62:247-53.10.1007/BF00332482
    Search in Google Scholar
  15. Persson KA, Berg S, Törnqvist M, Scalia-Tomba GP, Ehrenberg L. Note on ethene and other low-molecular weight hydrocarbons in environmental tobacco smoke. Acta Chem Scand B 1988;42:690-6.10.3891/acta.chem.scand.42b-0690
    Search in Google Scholar
  16. Bader M, Lewalter J, Angerer J. Analysis of N-alkylated amino acids in human hemoglobin: evidence for elevated N-methylvaline levels in smokers. Int Arch Occup Environ Health 1995;67:237-42.10.1007/BF00409405
    Search in Google Scholar
  17. van Sittert NJ, Angerer J, Bader M, Blaskewicz M, Ellrich D, Krämer A, Lewalter J. N-2-cyanoethylvaline, N-2-hydroxyethylvaline, N-methylvaline (as evidence of exposure to acrylonitrile, ethylene oxide and well as methylating agents). In: Angerer J, Schaller KH, editors. Analyses of hazardous substances in biological materials. Vol. 5. Weinheim: Wiley-VCH; 1997. p. 181-210.10.1002/3527600418.bi2176851e0005
    Search in Google Scholar
  18. Osterman-Golkar S, Ehrenberg L, Segerbäck D, Hällström I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat Res 1976;34:1-10.10.1016/0027-5107(76)90256-6
    Search in Google Scholar
  19. Osterman-Golkar S. Dosimetry of ethylene oxide. IARC Sci Publ 1988;89:249-57.
    Search in Google Scholar
  20. Granath F, Ehrenberg L, Törnqvist M. Degree of alkylation of macromolecules in vivo from variable exposure. Mutat Res 1992;284:297-306.10.1016/0027-5107(92)90014-S
    Search in Google Scholar
  21. Fennell TR, Sumner SCJ, Walker VE. A model for the formation and removal of hemoglobin adducts. Cancer Epidemiol Biomarkers Prev 1992;1:213-9.
    Search in Google Scholar
  22. Schettgen T, Broding HC, Angerer J, Drexler H. Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. Toxicol Letters 2002;34:65-70.10.1016/S0378-4274(02)00164-9
    Search in Google Scholar
  23. Bader M, Hecker H, Wrbitzky R. Querschnittstudie zur ernährungs- und tabakrauchbedingten Belastung der Allgemeinbevölkerung mit Acrylamid [Cross-sectional study on dietary and smoking related exposure to acrylamide, in German]. Dtsch Ärztebl 2005;39:B2231-4.
    Search in Google Scholar
  24. Müller M, Heinrich-Ramm R, Hoppe HW. Cotinine. In: Angerer J, Schaller KH editors. Analyses of hazardous substances in biological materials. Vol. 8. Weinheim: Wiley-VCH; 2003. p. 53-65.
    Search in Google Scholar
  25. Tsikas D, Wolf A, Mitschke A, Gutzki FM, Will W, Bader M. GC-MS determination of creatinine in human biological fluids as pentafluorobenzyl derivative in clinical studies and biomonitoring: Interlaboratory comparison in urine with Jaffé, HPLC and enzymatic assays. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:2582-92.10.1016/j.jchromb.2010.04.025
    Search in Google Scholar
  26. BASF Chemical Emergency Medical Guidelines. Ethylene oxide [displayed 17 May 2012]. Available at http://www.basf.com/group/corporate/en/sustainability/employees/occupational-medicine/responsiblecare
    Search in Google Scholar
  27. UBA (Umweltbundesamt, German Federal Environment Agency) Umwelt-Survey 1998, Band III: Human-Biomonitoring. Stoffgehalte in Blut und Urin der Bevölkerung in Deutschland. WaBoLu-Hefte 2002;1:214.
    Search in Google Scholar
  28. Törnqvist M, Gustafsson B, Kautiainen A, Harms-Ringdahl M, Granath F, Ehrenberg L. Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide. Carcinogenesis 1989;10:39-41.10.1093/carcin/10.1.39
    Search in Google Scholar
  29. Walker VE, MacNeela JP, Swenberg JA, Turner MJ, Fennell TR. Molecular dosimetry of ethylene oxide: Formation and Persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice. Cancer Res 1992;52:4320-7.
    Search in Google Scholar
  30. Granath F, Westerholm R, Peterson A, Törnqvist M, Ehrenberg L. Uptake and metabolism of ethene studied in a smoke-stop experiment. Mutat Res 1994;313:285-91.10.1016/0165-1161(94)90058-2
    Search in Google Scholar
  31. Bader M, Wrbitzky R. Follow-up biomonitoring after accidental exposure to acrylonitrile - Implications for protein adducts as a dose monitor for short-term exposures. Toxicol Lett 2006;162:125-31.10.1016/j.toxlet.2005.09.03416280213
    Search in Google Scholar
  32. Filser JG, Denk B, Törnqvist M, Kessler W, Ehrenberg L. Pharmacokinetics of ethylene oxide in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch Toxicol 1992;66:157-63.10.1007/BF019740081303633
    Search in Google Scholar
DOI: https://doi.org/10.2478/10004-1254-63-2012-2211 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Journal RSS Feed
Language: English, Slovenian
Page range: 107 - 115
Published on: Jun 21, 2012
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
accidental exposure,
haemoglobin adduct kinetics,
occupational exposure
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2012 Michael Bader, Wolfgang Will, Gunild Frey, Michael Nasterlack, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 63 (2012): Issue 2 (June 2012)