Have a personal or library account? Click to login
Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium Cover

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Open Access
|Mar 2011

References

  1. Nordberg NF. Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 2009;238:192-200.10.1016/j.taap.2009.03.015
  2. Friberg L. Proteinuria and kidney injury among workmen exposed to cadmium and nickel dust. J Ind Hyg Toxicol 1948;30:32-6.
  3. Tcuchiya K. Causation of ouch-ouch disease (Itai-Itai Byõ) an introductory review. II. Epidemiology and evaluation. Keio J Med 1969;18:181-94.10.2302/kjm.18.181
  4. Margoshes M, Vallee BL. A cadmium protein from equine kidney cortex. J Am Chem Soc 1957;79:4813-4.10.1021/ja01574a064
  5. Kagi JH, Vallee BL. Metallothionein: a cadmium- and zinccontaining protein from equine renal cortex. J Biol Chem 1960;235:3460-5.10.1016/S0021-9258(18)64490-4
  6. Sabolić I, Breljak D, Škarica M, Herak-Kramberger CM. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. Biometals 2010;23(5 Special Issue):897-926.10.1007/s10534-010-9351-z20549307
  7. Memiši N, Žujović M, Bogdanović V, Tomić Z, Petrović MP. The influence of presence of cadmium and arsenic in feedmeal on production and reproduction traits of goats. Biotechnol Anim Husbandry 2008;24:39-47.10.2298/BAH0804039M
  8. Lane TW, Saito MA, George GN, Pickering IJ, Prince RC, Morell FMM. Biochemistry: A cadmium enzyme from a marine diatom. Nature 2005;435:42.10.1038/435042a15875011
  9. Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004;4:11-8.10.1021/nl0347334558868828890669
  10. Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz Javier A, Gaub HE, Stölzle S, Fertig N, Parak WJ. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005;5:331-8.10.1021/nl047996m15794621
  11. Green M, Howman E. Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun 2005;1: 121-3.10.1039/b413175d15614393
  12. Smith AM, Duan h, Mohs AM, Nie S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Delivery Rev 2008;60:1226-40.10.1016/j.addr.2008.03.015
  13. New insights into the mechanisms of cadmium toxicity - Advances in cadmium research, Special issue. Toxicol Appl Pharmacol 2009;238 (3): 191-326.
  14. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium. Atlanta (USA): ATSDR; 2008.
  15. Lewis GP, Coughlin LL, Jusko WJ, Hartz S. Contribution of cigarette smoking to cadmium accumulation in man. Lancet 1972;299:291-2.10.1016/S0140-6736(72)90294-2
  16. Nawrot TS, Staessen JA, Roels HA, Munters E, Cuypers A, Richart T, Ruttens A, Smeets K, Clijsters h, Vangronsveld J. Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 2010;23:769-82.10.1007/s10534-010-9343-z20517707
  17. Agency for Toxic Substances and Disease Registry (ATSDR). CERCLA Priority list of hazardous substances that will be the subject of toxicological profiles and support document. Atlanta (USA): ATSDR, U. S. Department of Health and Human Services; 2007.
  18. Bhattacharyya MH. Cadmium osteotoxicity in experimental animals: Mechanisms and relationship to human exposures. Toxicol Appl Pharmacol 2009;238:258-65.10.1016/j.taap.2009.05.015282616519463839
  19. Everett CJ, Frithsen IL. Association of urinary cadmium and myocardial infarction. Environ Res 2008;106:284-6.10.1016/j.envres.2007.10.00918053980
  20. Edwards JR, Prozialeck WC. Cadmium, diabetes and chronic kidney disease. Toxicol Appl Pharmacol 2009;238:289-93.10.1016/j.taap.2009.03.007270971019327375
  21. Darbre PD. Metalloestrogens: An emerging class of inorganic xenoestrogens with potential to add to the estrogenic burden of the human breast. J Appl Toxicol 2006;26:191-7.10.1002/jat.113516489580
  22. McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst 2006;98:869-73.10.1093/jnci/djj23316788160
  23. Il'yasova D, Schwartz GG. Cadmium and renal cancer. Toxicol Appl Pharmacol 2005;207:179-86.10.1016/j.taap.2004.12.00516102569
  24. International Agency for Research on Cancer (IARC). Cadmium and cadmium compounds, In: IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 58. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. Lyon: IARC; 1993. p. 119-237.
  25. NTP Report on Carcinogens Background Document for Cadmium, March 1999. NIEHS Contract No. NO1-ES-25346 [displayed 9 January 2011]. Available at http://ntp.niehs.nih.gov/files/Cadmium.pdf
  26. Nawrot TS, Van Hecke E, Thijs L, Richart T, Kuznetsova T, Jin Y, Vangronsveld J, Roels HA, Staessen JA. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect 2008;116:1620-8.10.1289/ehp.11667259975419079711
  27. Jin YH, Clark AB, Slebos RJ, Al-Refai h, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 2003;34: 326-9.10.1038/ng1172
  28. Pan J, Plant JA, Voulvoulis N, Oates CJ, Ihlenfeld C. Cadmium levels in Europe: implications for human health. Environ Geochem Health 2010;32:1-12.10.1007/s10653-009-9273-2
  29. Joseph P. Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharmacol 2009;238:272-9.10.1016/j.taap.2009.01.011
  30. Moulis J-M. Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals 2010;23:877-96.10.1007/s10534-010-9336-y
  31. Matović V, Plamenac-Bulat Z, Djukić-Ćosić D, Soldatović D. Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. Magnesium Res 2010;23:19-26.10.1684/mrh.2010.0196
  32. Lazarus M. Međudjelovanje kadmija i selenija u sisavaca. Arh Hig Rada Toksikol 2010;61:357-69.10.2478/10004-1254-61-2010-2021
  33. Müller L. Consequences of cadmium toxicity in rat hepatocytes: Mitochondrial dysfunction and lipid peroxidation. Toxicology 1986;40:285-95.10.1016/0300-483X(86)90061-2
  34. Hart BA, Lee CH, Shukla GS, Shukla A, Osier A, Eneman JD, Chiu JF. Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology 1999;133:43-5810.1016/S0300-483X(99)00013-X
  35. Liu F, Jan KY. DNA damage in arsenite-and cadmium-treated bovine aortic endothelial cells. Free Radic Biol Med 2000;28:55-63.10.1016/S0891-5849(99)00196-3
  36. Manca D, Richard AC, Tra HV, Chevalier G. Relation between lipid peroxidation and inflammation in the pulmonary toxicity of cadmium. Arch Toxicol 1994;68: 364-9.10.1007/s0020400500838092928
  37. Amara S, Abdelmelek H, Garrel C, Guiraud P, Douki T, Ravanat J-L, Favier A, Sakly M, Ben Rhouma K. Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev 2008;54:129-34.10.1262/jrd.18110
  38. Djukić-Ćosić D, Ćurčić-Jovanović M, Plamenac-Bulat Z, Ninković M, Maličević Z, Matović V. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication. J Trace Elem Med Biol 2008;22:66-72.10.1016/j.jtemb.2007.09.024
  39. Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-208.10.2174/0929867053764635
  40. Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009;238:209-14.10.1016/j.taap.2009.01.029
  41. Djukić-Ćosić D, Ninković M, Maličević Ž, Matović V, Soldatović D. Effect of magnesium pretreatment on reduced gluthatione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study. Magnes Res 2007;20:177-86.
  42. Casalino E, Sblano C, Landriscina C. Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 1997;346:171-9.10.1006/abbi.1997.0197
  43. Yamano T, DeCicco LA, Rikans LE. Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of Kupffer cells and inflammatory cytokines. Toxicol Appl Pharmacol 2000;162:68-75.10.1006/taap.1999.8833
  44. Belyaeva EA, Dymkowska D, Wieckowski MR, Wojtczak L. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharmacol 2008;231:34-42.10.1016/j.taap.2008.03.017
  45. Shaikh ZA, Vu TT, Zaman K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharmacol 1999;154:256-63.10.1006/taap.1998.8586
  46. Ramirez DC, Gimenez MS. Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages. Toxicol Lett 2003;145:121-32.10.1016/S0378-4274(03)00237-6
  47. Waisberg M, Joseph P, Hale B, Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003;192:95-117.10.1016/S0300-483X(03)00305-6
  48. Thijssen S, Cuypers A, Maringwa J, Smeets K, Horemans N, Lambrichts I, Van Kerkhove E. Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 2007;236:29-41.10.1016/j.tox.2007.03.022
  49. Qu W, Diwan BA, Reece JM, Bortner CD, Pi J, Liu J, Waalkes MP. Cadmium-induced malignant transformation in rat liver cells: Role of aberrant oncogene expression and minimal role of oxidative stress. Int J Cancer 2005;114:346-55.10.1002/ijc.20736
  50. Wuehler SE, Peerson JM, Brown KH. Use of national food balance data to estimate the adequacy of zinc in national food supplies: Methodology and regional estimates. Public Health Nutr 2005;8:812-9.10.1079/PHN2005724
  51. Task Group on Metal Interactions. Factors influencing metabolism and toxicity of metals: a consensus report. Environ Health Perspect 1978;25:3-41.
  52. Plamenac Z, Matović V, Vujanović D, Soldatović D. Zinc content in rabbits submitted to prolonged cadmium intoxication. In: Kovatsis AV, Tsoukali-Papadopoulou h, editors. Aspects on Forensis Toxicology. Greece: Thessaloniki-Tecnika Studio; 1995. p. 31-5.
  53. Brzóska MM, Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem Toxicol 2001;39:967-80.10.1016/S0278-6915(01)00048-5
  54. Ishitobi h, Watanabe C. Effects of low-dose perinatal cadmium exposure on tissue zinc and copper concentrations in neonatal mice and on the reproductive development of female offspring. Toxicol Lett 2005;159:38-46.10.1016/j.toxlet.2005.04.006
  55. Martelli A, Rousselet E, Dycke C, Bouron A, Moulis JM. Cadmium toxicity in animal cells by interference with essential metals. Biochimie 2006;88:1807-14.10.1016/j.biochi.2006.05.013
  56. Osman K, Akesson A, Berglund M, Bremme K, Schütz A, Ask K, Vahter M. Toxic and essential elements in placentas of Swedish women. Clin Biochem 2000;33:131-8.10.1016/S0009-9120(00)00052-7
  57. Sorell TL, Graziano JH. Effect of oral cadmium exposure during pregnancy on maternal and fetal zinc metabolism in the rat. Toxicol Appl Pharmacol 1990;102:537-45.10.1016/0041-008X(90)90048-Y
  58. Plamenac Bulat Z. Interakcije kadmijuma i bioelemenata cinka, bakra i magnezijuma kod ljudi i kunića izloženih kadmijumu [Interactions of cadmium and bioelements zinc, copper and magnesium in humans and rabbits exposed to cadmium, in Serbian]. [PhD thesis]. Belgrade: Faculty of Pharmacy, University of Belgrade; 2009.
  59. Soldatović D, Matović V, Vujanović D, Stojanović Z. Contribution to interaction between magnesium and toxic metals: the effect of prolonged cadmium intoxication on magnesium metabolism in rabbits. Magnes Res 1998;11: 283-8.
  60. Smetana RH, Glogar DH, Gemeiner M. Role of cadmium and magnesium in pathogenesis of idiopathic dilated cardiomyopathy. Am J Cardiol 1986;58:364-6.10.1016/0002-9149(86)90082-2
  61. Ezaki T, Tsukahara T, Moriguchi J, Furuki K, Fukui Y, Ukai H, Okamoto S, Sakurai H, Honda S, Ikeda M. Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan. Int Arch Occup Environ Health 2003;76:197-204.10.1007/s00420-002-0390-912690494
  62. Plamenac Bulat Z, Đukić-Ćosić D, Đokić M, Bulat P, Matović V. Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia. Toxicol Ind Health 2009;25:129-35.10.1177/074823370910448819458135
  63. World Health Organization (WHO). Cadmium. Environmental Health Criteria No. 134. Geneva: WHO; 1992.
  64. Pařizek J. The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J Endocrinol 1957;15: 56-63.10.1677/joe.0.015005613439083
  65. Barbier O, Jacquillet G, Taue M, Poujeol P, Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am J Physiol Renal Physiol 2004;287:F1067-75.10.1152/ajprenal.00120.200415280159
  66. Jacquillet G, Barbier O, Cougnon M, Tauc M, Namorado MC, Martin D, Reyes JL, Poujeol P. Zinc protects renal function during cadmium intoxication in the rat. Am J Physiol Renal Physiol 2006;290:F127-37.10.1152/ajprenal.00366.200415942048
  67. Brzóska MM, Rogalska J, Galazyn-Sidorczuk M, Jurczuk M, Roszczenko A, Kulikowska-Karpińska E, Moniuszko-Jakoniuk J. Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium. Toxicology 2007;237:89-103.10.1016/j.tox.2007.05.00117560002
  68. Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR. Cadmium carcinogenesis in male wistar [Crl:(WI)BR] rats: Doseresponse analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res 1989;49:4282-8.
  69. Hu Y, Jin T, Zhou T, Pang B, Wang Y. Effects of zinc on gene expressions induced by cadmium in prostate and testes of rats. Biometals 2004;17:571-2.10.1023/B:BIOM.0000045835.21954.c7
  70. Bulat PZ, Djukić-Ćosić D, Maličević Ž, Bulat P, Matović V. Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. Biol Trace Elem Res 2008;124:110-7.10.1007/s12011-008-8128-518418555
  71. Bridges CC, Zalups RK. Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharm 2005;204:274-308.10.1016/j.taap.2004.09.007240929115845419
  72. Jihen EH, Fatima H, Nouha A, Baati T, Imed M, Abdelhamid K. Cadmium retention increase: A probable key mechanism of the protective effect of zinc on cadmium-induced toxicity in the kidney. Toxicol Lett 2010;196:104-9.10.1016/j.toxlet.2010.04.00620394811
  73. Boujelben M, Ghorbel F, Vincent C, Makni-Ayadi F, Guermazi F, Croute F, El-Feki A. Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation. Exp Toxicol Pathol 2006;57:437-43.10.1016/j.etp.2006.02.01216616466
  74. Djukić-Ćosić D, Ninković M, Maličević Z, Plamenac-Bulat Z, Matović V. Effect of supplemental magnesium on the kidney levels of cadmium, zinc, and copper of mice exposed to toxic levels of cadmium. Biol Trace Elem Res 2006;114:281-92.10.1385/BTER:114:1:281
  75. Blanuša M, Varnai VM, Piasek M, Kostial K. Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem 2005;12:2771-94.10.2174/092986705774462987
  76. Brzóska MM, Galazyn-Sidorczuk M, Rogalska J, Roszczenko A, Jurczuk M, Majewska K, Moniuszko-Jakoniuk J. Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium. Chem Biol Interact 2008;171:312-24.10.1016/j.cbi.2007.11.007
  77. Rogalska J, Brzóska MM, Roszczenko A, Moniuszko-Jakoniuk J. Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats. Chem Biol Interact 2009;177:142-52.10.1016/j.cbi.2008.09.011
  78. Waalkes MP. Cadmium carcinogenesis. Mutat Res 2003;533:107-20.10.1016/j.mrfmmm.2003.07.011
  79. Liu X, Jin T, Nodberg GF, Rännar S, Sjöström M, Zhou Y. A multivariate study of protective effects of Zn and Cu against nephrotoxicity induced by cadmium metallothionein in rats. Toxicol Appl Pharmacolacol 1992;114:239-45.10.1016/0041-008X(92)90074-3
  80. Turgut S, Enli Y, Emmungil G, Turgut G, Demir S, Kaptanoglu B, Genc O. Influence of cadmium and copper on tissue element levels of pregnant rats. Cent Eur J Med 2007;2:447-57.10.2478/s11536-007-0047-x
  81. Matović V, Plamenac-Bulat Z, Djukić-Ćosić D, Soldatović D. Zinc, copper or magnesium supplementation against cadmium toxicity: an experimental study. In: Blanc G, Moreu D, editors. Biometals: Molecular Structures, Binding Properties and Applications. 1st ed. New York (NY): Nova Science Publisher; 2010. p. 1-31.
  82. Matović V, Soldatović D, Vujanović D. Magnesium against lead: new approach to prophylaxis and therapy of chronic lead intoxication. In: Kotsaki-Kovatsi VP, Vafiadu AJ, editors. Aspects on Environmental Toxicology. Thessaloniki: Tecnika Studio; 1995. p. 78-82.
  83. Soldatović D, Matović V, Vujanović D. Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes Res 1993;6:145-8.
  84. Soldatović D, Vujanović D, Matović V, Stojanović Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. Magnes Res 1997;10:127-33.
  85. Soldatović D, Matović V. Influence of magnesium on the urinary lead excretion in rabbits submitted to chronic lead intoxication. In: Chhaparwal B, Durlach J, editors. Magnesium Research New Vistas. Indora: India; 1999. p. 125-31.
  86. Soldatović D, Matović V, Vujanović D, Guiet-Bara A, Bara M, Durlach J. Metal pollutants and bioelements: retrospective of interactions between magnesium and toxic metals. Magnes Res 2002;15:67-72.
DOI: https://doi.org/10.2478/10004-1254-62-2011-2075 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Language: English, Slovenian
Page range: 65 - 76
Published on: Mar 21, 2011
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2011 Vesna Matović, Aleksandra Buha, Zorica Bulat, Danijela Đukić-Ćosić, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 62 (2011): Issue 1 (March 2011)