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Potentiation of Bleomycin Lethality in HeLa and V79 Cells by Bee Venom Cover

Potentiation of Bleomycin Lethality in HeLa and V79 Cells by Bee Venom

By: Nada Oršolić  
Open Access
|Sep 2009

References

  1. Oršolić N, Šver L, Verstovšek S, Terzić S, Bašić I. Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom. Toxicon 2003;41:861-70.10.1016/S0041-0101(03)00045-X
  2. Oršolić N, Sacases F, Percie du Sert P, Bašić I. Antimetastatic ability of honey bee products. Period Biol 2007;109:173-80.
  3. Liu S, Yu M, He Y, Xiao L, Wang F, Song C, Sun S, Ling C, Xu Z. Melittin prevents liver cancer cell metastasis through inhibition of the Rac 1-dependent pathway. Hepatology 2008;47:1964-73.10.1002/hep.22240
  4. Liu X, Chen DW, Xie LP, Rongqing Z. Effect of honey bee venom on proliferation of K1735M2 mouse melanoma cells in-vitro and growth of murine B 16 melanomas in-vivo. J Pharm Pharmacol 2002 54:1083-9.10.1211/002235702320266235
  5. Yusuf N, Irby C, Katiyar SK, Elmets CA. Photoprotective effects of green tea polyphenols. Photodermatol Photoimmunol Photomed 2007;23:48-56.10.1111/j.1600-0781.2007.00262.x
  6. Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz, AJ, Le E JH. Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain 2001;90:271-80.10.1016/S0304-3959(00)00412-7
  7. Raghuraman H, Chattopadhyay A. Melittin: a membraneactive peptide with diverse functions. Biosci Rep 2007;27:189-223.10.1007/s10540-006-9030-z
  8. Habermann E, Jentsch J. Sequential analysis of melittin from triptic and peptic fragments. Biochem J 1967;348:37-42.
  9. Gauldie J, Hanson JM, Shipolini RA, Vernon CA. The structures of some peptides from bee venom. Eur J Biochem 1978;83:405-10.10.1111/j.1432-1033.1978.tb12106.x
  10. Habermann E. Bee and wasp venoms: The biochemistry and pharmacology of their peptides and enzymes are reviewed. Science 1972;177:314-22.10.1126/science.177.4046.314
  11. Orlov BN, Romanova EB, Omarov SM. Immunological properties of bee venom. In: Proceedings of the XXVIIIth International Congress of Apiculture; 23-29 Oct 1981; Acapulco, Mexico. Bucharest, Romania; Apimondia Publishing House; 1981. p. 490-3.
  12. Orlov BN. Theoretical basis for therapeutical use of bee venom. Apiacta 1979;14:12-5.
  13. Sharma SV. Melittin-induced hyperactivation of phospholipase A2 activity and calcium influx in ras-transformed cells. Oncogene 1993;8:939-47.
  14. Hait WN, Cadman E, Benz C, Cole J, Weiss B. Inhibition of cyclic nucleotide phosphodiesterase and calmodulin. Proc Am Assoc Cancer Res 1983;2:5-9.
  15. Hait WN, Grais L, Benz C, Cadman EC. Inhibition of growth of leukemic cells by inhibitors of calmodulin: phenothiazines and melittin. Cancer Chemother Pharmacol 1985;14:202-5.10.1007/BF00258116
  16. Hait WN, Lee GL. Characterization of the cytotoxic effects of calmodulin inhibitors. Clin Res 1984;32:416A.
  17. Lee GL, Hait WN. Growth inhibition of C6 astrocytoma cells by inhibitions of calmodulin. Life Sci 1985;36:347-54.10.1016/0024-3205(85)90120-1
  18. Okumara K, Kato T, Ito J, Tanaka R. Inhibition by calmodulin antagonists of glioblast DNA synthesis and morphological changes induced by glial maturation factor. Dev Brain Res 1982;255:661-5.
  19. Means AR, Chafouleas JA, Lagace L, Lai E, Stein JP. Multiple roles for calmodulin in the regulation of eukaryotic cell metabolism. In: O'Malley BW, editor. Gene regulation. New York: Academic Press; 1982. p. 307-26.10.1016/B978-0-12-525960-6.50027-4
  20. Chafouleas JG, Bolton WE, Hidaka H, Boyd AE, Means AR. Calmodulin and the cell cycle: involvement in regulation of cell cycle progression. Cell 1982;28:41-50.10.1016/0092-8674(82)90373-7
  21. Chafouleas JG, Botton WE, Means AR. Potentiation of bleomycin lethality by anti-calmodulin drugs: a role for calmodulin in DNA repair. Science 1984;224:1346-8.10.1126/science.6203171
  22. Gamapathi R, Grabowski D. Enhancement of sensitivity to adriamyc in resistant P388 leukemia by the calmodulin inhibitor, trifluoperazine. Cancer Res 1983;43:3696-9.
  23. Tsuro T, Iida H, Tsukagoshi S, Sakurai Y. Increased accumulation of vineristine and adriamycin in drug-resistant P388 tumor cells following with calcium antagonists and calmodulin inhibitors. Cancer Res 1982;42:4730-3.
  24. Wei JW, Hickie RA, Klaassen DJ. Inhibition of human breast cancer colony formation by anticalmodulin agents, trifluoperazine, W-7 and W-13. Cancer Chemother Pharmacol 1983;11:86-90.10.1007/BF00254251
  25. Ito, H, Hidaka H. Antitumor effect of a calmodulin antagonist on the growth of solid sarcoma-180. Cancer Lett 1983;19:215-9.10.1016/0304-3835(83)90157-X
  26. Oršolić N, Josipović P, Bašić I. Direct antitumor activity of honey bee venom in vivo and in vitro. Egypt J Nat Tox 2009;6:1-16.
  27. Gajski G, Garaj-Vrhovac V. Genotoxic potential of bee venom (Apis Mellifera) on human peripheral blood lymphocytes in vitro using single cell gel electrophoresis assay. J Environ Sci Health A Tox Hazard Subst Environ Eng 2008;43:1279-87.10.1080/10934520802177862
  28. Telford WG, King LE, Fraker PJ. Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. J Immunol Methods 1994;172:1-16.10.1016/0022-1759(94)90373-5
  29. Levin RM, Weiss B. Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleutide phosphodiesterase. Mol Pharmacol 1977;13:690-5.
  30. Sellinger-Barnette M, Weiss B. Interaction of various peptides with calmodulin. In: Greengard P, Robinson GA, editors. Advances in cyclic nucleotide and protein phosphorylation research. New York (NY): Raven Press; 1984. p. 261-76.
  31. Killion JJ, Dunn JD. Differential cytolysis of murine spleen, bone-marrow and leukemia cells by melittin reveals differences in membrane topography. Biochem Biophys Res Commun 1986;139:222-7.10.1016/S0006-291X(86)80102-4
  32. Balk SD, Polimeni PI, Hoon BS, LeStourgeon DN, Mitchell RS. Proliferation of Rous sarcoma virus-infected, but not of normal chicken fibroblasts in a medium of reduced calcium and magnesium concentration. Proc Natl Acad Sci USA 1979;76:3913-6.10.1073/pnas.76.8.3913383946226989
  33. Whitfield JF, Boynton AL, MacManus JP, Sicorska M, Tsang BK. The regulation of cell proliferation by calcium and cyclic AMP. Mol Cell Biochem 1979;27:155-79.10.1007/BF00215364229407
  34. Barnette MS, Daly R, Weiss B. Inhibition of calmodulin activity by insect venom peptides. Biochem Pharmacol 1983;32:2929-33.10.1016/0006-2952(83)90398-2
  35. Comte M, Maulet Y, Cox JA. Ca2+ dependent high affinity complex formation between calmodulin and melittin. Biochem J 1983;209:269-72.10.1042/bj2090269
  36. Maulet Y, Cox JA. Structural changes in melittin and calmodulin upon complex formation and their modulation by calcium. Biochemistry 1983;22:5680-6.10.1021/bi00293a035
  37. Tanaka J, Takahashi S, Mitsui Y, Itoh S, Iitaka Y, Kasai H, Okuyama T. X-Ray crystallographic and chromatographic characterization of the crystals of Ca2+-calmodulin complexed with bee venom melittin. J Mol Biol 1985;186:675-7.10.1016/0022-2836(85)90141-X
  38. Cheung WY. Calmodulin: an overview. Fed Proc 1982;41:2253-7.
  39. Weiss B, Wallace TL. Mechanism and pharmacological implications of altering calmodulin activity In: Cheung WY, editor. Calcium and cell function. Vol. 1. New York (NY): Academic Press; 1980. p. 329-79.10.1016/B978-0-12-171401-7.50021-5
  40. Zimmerman TP, Wolberg G. Effect of calmodulin antagonists on lymphocyte-mediated cytolysis. Proc Am Assoc Cancer Res 1984;25:351-5.
  41. Melino G, Knight RA, Nicotera P. How many ways to die? How many different models of cell death? Cell Death Differ 2005;12(Suppl 2):1457-62.10.1038/sj.cdd.440178116247490
  42. Lennon SV, Kilfeathr SA, Hallett MB, Campbell AK, Cotter, TG. Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukemia cells. Clin Exp Immunol 1992;87:465-71.10.1111/j.1365-2249.1992.tb03021.x15543311544231
  43. Oberhammer F, Fritsch G, Schmied M. Condensation of the cromation at the membrane of an apoptotic nucleus is not associated with activation an endonuclease. J Cell Sci 1993;104;317-26.10.1242/jcs.104.2.3178389375
  44. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR, Sikorska M. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993;12:3679-84.10.1002/j.1460-2075.1993.tb06042.x4136448253089
  45. Zakeri ZF, Quaglino D, Latham T, Lockshin, RA. Delayed internucleosomal DNA fragmentation in programmed cell death. FASEB J 1993;7:470-8.10.1096/fasebj.7.5.84627898462789
  46. Tu WC, Wu CC, Hsieh HL, Chen CY, Hsu SL. Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells. Toxicon 2008;52;318-29.10.1016/j.toxicon.2008.06.00718602939
  47. Chu ST, Cheng HH, Huang CJ, Chang HC, Chi CC, Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Lu YC, Huang JK, Ho CM, Jan CR. Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells. Life Sci 2007;80;364-9.10.1016/j.lfs.2006.09.02417054998
  48. Ip SW, Wei HC, Lin JP, Kuo HM, Liu KC, Hsu SC, Yang JS, Mei-Dueyang Chiu TH, Han SM, Chung JG. Bee venom induced cell cycle arrest and apoptosis in human cervical epidermoid carcinoma Ca Ski cells. Anticancer Res 2008;28:833-42.
  49. Ip SW, Liao SS, Lin SY, Lin JP, Yang JS, Lin mL, Chen GW, Lu HF, Lin MW, Han SM, Chung JG. The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7 cells. In Vivo 2008;22;237-45.
  50. Moon DO, Park SY, Choi YH, Kim ND, Lee C, Kim GY. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon 2008;51:112-20.10.1016/j.toxicon.2007.08.01517936321
  51. Wang C, Chen T, Zhang N, Yang M, Li B, Lu X, Cao X, Ling C. Melittin, a major component of Bee Venom, sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IKK-NFkappa B. J Biol Chem 2009;284:384-13.
DOI: https://doi.org/10.2478/10004-1254-60-2009-1936 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Language: English, Croatian, Slovenian
Page range: 317 - 326
Published on: Sep 29, 2009
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2009 Nada Oršolić, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 60 (2009): Issue 3 (September 2009)