References
- Varanda EA, Tavares DC. Radioprotection: Mechanism and radioprotective agents including honey bee venom. Venom Anim Toxins 1998;4:5-21.
- Varanda EA, Monti R, Tavares DC. Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens. Teratogen Carcinogen Mutagen 1999;19:403-13.
- Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, Kang SK, Mar W. Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble subfractionated parts from bee (Apis mellifera) venom. Arch Pharm Res 2003;26:383-8.
- Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Lee HJ, Han HJ, Yang IS, Beitz AJ, Lee JH. Acupoint stimulation using bee venom attenuates formalin-induced pain behavior and spinal cord fos expression in rats. J Vet Med Sci 2003;65:349-55.
- Orsolic N, Sver L, Verstovsek S, Terzic S, Basic I. Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom. Toxicon 2003;41:861-70.
- Liu X, Chen D, Xie L, Zhang R. Effect of honey bee venom on proliferation of K1735M2 mouse melanoma cells in-vitro and growth of murine B16 melanomas in-vivo. J Pharm Pharmacol 2002;54:1083-9.
- Jang MH, Shin MC, Lim S, Han SM, Park HJ, Shin I. Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299. J Pharmacol Sci 2003;91:95-104.
- Yin CS, Lee HJ, Hong SJ, Chung JH, Koh HG. Microarray analysis of gene expression in chondrosarcoma cells treated with bee venom. Toxicon 2005;45:81-91.
- Hu H, Chen D, Li Y, Zhang X. Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC-7721 in-vitro and Balb/c nude mice in-vivo. J Pharm Pharmacol 2006;58:83-9.
- Moon DO, Park SY, Heo MS, Kim KC, Park C, Ko WS. Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt. Int Immunopharmacol 2006;6:1796-807.
- Han S, Lee K, Yeo J, Kweon H, Woo S, Lee M, Baek H, Kim S, Park K. Effect of honey bee venom on microglial cells nitric oxide and tumor necrosis factor-alpha production stimulated by LPS. J Ethnopharmacol 2007;111:176-81.
- Habermann E. Bee and wasp venoms. Science 1972;177:314-22.
- Dotimas EM, Hamid KR, Hider RC, Ragnarsson U. Isolation and structure analysis of bee venom mast cell degranulating peptide. Biochim Biophys Acta 1987;911:285-93.
- Neumann W, Habermann E. Characterization of the substances of the bee venom. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 1954;222:267-87.
- Vogel H. Incorporation of melittin into phosphatidylcholine bilayers. Study of binding and conformational changes. FEBS Lett 1981;134:37-42.
- Gauldie J, Hanson JM, Rumjanek FD, Shipolini RA, Vernon CA. The peptide components of bee venom. Eur J Biochem 1976;1:369-76.
- Gevod VS, Birdi KS. Melittin and the 8-26 fragment. Differences in ionophoric properties as measured by monolayer method. Biophys J 1984;45:1079-83.
- Habermann E. Chemistry, pharmacology, and toxicology of bee, wasp and hornet venoms. In: Bucherl W, and Buckley EE, editors. Venomous animals and their venoms. Vol. 3. New York (NY): Academic Press; 1971. p. 61-93.
- Fletcher JE, Jiang MS. Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin. Toxicon 1993;31:669-95.
- Gajski G, Ravlic S, Capuder Z, Garaj-Vrhovac V. Use of sensitive methods for detection of DNA damage on human lymphocytes exposed to p,p'-DDT: Comet assay and new criteria for scoring micronucleus test. J Environ Sci Health B 2007;42:607-13.
- Gajski G, Garaj-Vrhovac V. Application of cytogenetic endpoints and comet assay on human lymphocytes treated with atorvastatin in vitro. J Environ Sci Health A Tox Hazard Subst Environ Eng 2008;43:78-85.
- Gajski G, Garaj-Vrhovac V, Orescanin V. Cytogenetic status and oxidative DNA-damage induced by atorvastatin in human peripheral blood lymphocytes: Standard and Fpg-modified comet assay. Toxicol Appl Pharmacol 2008;231:85-93.
- Singh NP, McCoy MT, Tice RR, Schneider LL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.
- Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res 1985;147:29-36.
- Duke RC, Cohen JJ. Morphological and biochemical assays of apoptosis. In: Coligan JE, Kruisbeal AM, editors. Current protocols in immunology. New York (NY): John Willey & Sons; 1992. p. 1-3.
- Singh NP. Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat Res 2000;455:111-27.
- Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004;26:249-61.
- Betti C, Davini T, Giannessi L, Loprieno N, Barale R. Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects. Mutat Res 1994;307:323-33.
- Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E. HUMN project: detailed description of scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res 2003;534:65-75.
- Henderson L, Wolfreys A, Fedyk J, Bourner C, Windebank S. The ability of the Comet assay to discriminate between genotoxins and cytotoxins. Mutagenesis 1998;13:89-94.
- Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35:206-16.
- Hellman B, Vaghef H, Boström B. The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay. Mutat Res 1995;336:123-31.
- Kumaravel TS, Vilhar B, Faux SP, Jha AN. Comet Assay measurements: a perspective. Cell Biol Toxicol 2009;25:53-64.
- Olive PL. DNA damage and repair in individual cells: applications of the comet assay in radiobiology. Int J Radiat Biol 1999;75:395-405.
- Piperakis SM, Visvardis EE, Tassiou AM. Comet assay for nuclear DNA damage. Methods Enzymol 1999;300:184-94.
- Kirsch-Volders M, Sofuni T, Aardema M, Albertini S, Eastmond D, Fenech M, Ishidate MJr, Kirchner S, Lorge E, Morita T, Norppa H, Surralles J, Vanhauwaert A, Wakata A. Report from the in vitro micronucleus assay working group. Mutat Res 2003;540:153-63.
- Fenech M. The in vitro micronucleus technique. Mutat Res 2000;455:81-95.
- Fenech M. Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. Mutat Res 2006;600:58-66.
- Garaj-Vrhovac V, Gajski G, Ravlić S. Efficacy of HUMN criteria for scoring the micronucleus assay in human lymphocytes exposed to a low concentration of p,p'-DDT. Braz J Med Biol Res 2008;41:473-6.
- Garaj-Vrhovac V, Đurinec M, Kojpar N, Oreščanin V. A survey on the cytogenetic status of the Croatian general population by use of the cytokinesis-block micronucleus assay. Mutat Res 2008;649:91-100.
- Gajski G, Garaj-Vrhovac V. Genotoxic potential of bee venom (Apis mellifera) on human peripheral blood lymphocytes in vitro using single cell gel electrophoresis assay. J Environ Sci Health A Tox Hazard Subst Environ Eng 2008;43:1279-87.
- Lee YJ, Kang SJ, Kim BM, Kim YJ, Woo HD, Chung HW. Cytotoxicity of honeybee (Apis mellifera) venom in normal human lymphocytes and HL-60 cells. Chem Biol Interact 2007;169:189-97.
- Ip SW, Liao SS, Lin SY, Lin JP, Yang JS, Lin ML, Chen GW, Lu HF, Lin MW, Han SM, Chung JG. The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7 cells. In Vivo 2008;22:237-45.
- Stuhlmeier KM. Apis mellifera venom and melittin block neither NF-kappa B-p50-DNA interactions nor the activation of NF-kappa B, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates. J Immunol 2007;179:655-64.