Genetics of amyotrophic lateral sclerosis: more than twenty years of studies

Mazzini, Letizia; Marchi, Fabiola De; Corrado, Lucia; D’Alfonso, Sandra

doi:10.24190/ISSN2564-615X/2017/S2.05

Abstract

Amyotrophic lateral sclerosis, also known as motor neuron disease or Lou Gehrig’s disease, is an adult-onset neurodegenerative disease that targets motor neurons in the spinal cord, cortex and brain stem. Selective degeneration of corticospinal (upper) and spinal (lower) motor neurons manifests as a linear decline in muscular function, eventually resulting in paralysis, speech and swallowing deficits and death, usually from impaired respiratory function, over a time course of approximately 3-5 years.

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Genetics of amyotrophic lateral sclerosis: more than twenty years of studies

Abstract

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