Have a personal or library account? Click to login
cis- and trans- regulation controls of human meiotic recombination at a hotspot Cover

cis- and trans- regulation controls of human meiotic recombination at a hotspot

Open Access
|Oct 2017

References

  1. 1. Jeffreys AJ, Ritchie A, Neumann R. High resolution analysis of haplotype
  2. diversity and meiotic crossover in the human TAP2 recombination
  3. hotspot. Hum Mol Genet 2000; 9:725-331074997910.1093/hmg/9.5.725
  4. 2. Jeffreys AJ, Murray J, Neumann R. High-resolution mapping of
  5. crossovers in human sperm defines a minisatellite-associated recombination9734365
  6. hotspot. Mol Cell 1998; 2:267-73973436510.1016/S1097-2765(00)80138-0
  7. 3. Jeffreys AJ, Neumann R. Reciprocal crossover asymmetry and
  8. meiotic drive in a human recombination hot spot. Nat Genet
  9. 2002; 31:267-71
  10. 4. Myers S, Freeman C, Auton A, Donnelly P, McVean G. A common
  11. sequence motif associated with recombination hot spots and genome
  12. instability in humans. Nat Genet 2008; 40:1124-910.1038/ng.21319165926
  13. 5. Myers S, Bottolo Leonardo, Freeman C, McVean G, Donnelly P. A
  14. fine-scale map of recombination rates and hotspots across the
  15. human genome Science 2005; 310: 321-32410.1126/science.111719616224025
  16. 6. Baudat F, et al. PRDM9 is a major determinant of meiotic recombination
  17. hotspots in humans and mice. Science 2010; 327:836-840.10.1126/science.1183439429590220044539
  18. 7. Myers S, et al. Drive against hotspot motifs in primates implicates
  19. the PRDM9 gene in meiotic recombination. Science 2010
  20. 327:876-879.
  21. 8. Parvanov ED, Petkov PM, Paigen K. Prdm9 controls activation of
  22. mammalian recombination hotspots. Science 2010; 327:835.10.1126/science.1181495282145120044538
  23. 9. Hayashi K, Yoshida K, Matsul Y. A histone H3 methyltransferase
  24. controls epigenetic events required for meiotic prophase. Nature16292313
  25. 2005; 438:374-8
  26. 10. Berg IL, Neumann R, Lam KW, Sarbajna S, Odenthal-Hesse L, May
  27. CA, Jeffreys AJ PRDM9 variation strongly influences recombination
  28. hot-spot activity and meiotic instability in humans. Nat Genet20818382
  29. 2010; 42:859-63
  30. 11. Berg IL, Neumann R, Sarbajna S, Odenthal-Hesse L, Butler NJ, Jeffreys
  31. AJ. Variants of the protein PRDM9 differentially regulate a set
  32. human meiotic recombination hotspots highly active in African21750151
  33. populations. Proc Natl Acad Sci USA 2011; 108:12378-8310.1073/pnas.1109531108314572021750151
  34. 12. Maniatis N, Collins A, Xu CF, McCarthy LC, Hewett DR, Tapper
  35. W, Ennis S, Ke X, Morton NE. The first linkage disequilibrium (LD)
  36. maps: delineation of hot and cold blocks by diplotype analysis.11842208
  37. Proc Natl Acad Sci USA 2002; 99:2228-223310.1073/pnas.04268099912234711842208
  38. 13. McVean GA, Myers SR, Hunt S, Deloukas P, Bentley DR, Donnelly
  39. P. The fine-scale structure of recombination rate variation in the
  40. human genome. Science 2004 304:581-584.10.1126/science.109250015105499
  41. 14. Kauppi L, May CA, Jeffreys AJ. Analysis of meiotic recombination
  42. products from human sperm. Methods Mol Biol 2009; 557: 323-355.
  43. 15. Webb AJ, Berg IL, Jeffreys A. Sperm cross-over activity in regions
  44. of the human genome showing extreme breakdown of marker association.18650392
  45. Proc Natl Acad Sci USA 2008; 105: 10471-10476.10.1073/pnas.0804933105248323518650392
  46. 16. Jeffreys AJ, Kauppi L, Neumann R. Intensely punctate meiotic recombination
  47. in the class II region of the major histocompatibility
  48. complex. Nat Genet 2001; 29:217-222.10.1038/ng1001-2171158630311586303
  49. 17. Jeffreys AJ, Neumann R. Factors influencing recombination frequency
  50. and distribution in a human meiotic crossover hotspot.
  51. Hum Mol Genet 2005; 14:2277-8710.1093/hmg/ddi2321598769815987698
  52. 18. Ergoren MC (2013) Control of meiotic recombination at a human
  53. crossover hotspot. University of Leicester, Leicester, United Kingdom.
  54. 19. Holloway K, Lawson VE, Jeffreys AJ. Allelic recombination and de
  55. novo deletions in sperm in the human beta-globin gene region.16501000
  56. Hum Mol Genet 2006; 15:1099-111
  57. 20. Sarbajna S, Denniff M, Jeffreys AJ, Neumann R, Soler Artigas M, Veselis A, May CA. A major recombination hotspot in the XqYq
  58. preudoautosomal region gives new sights into processing of human
  59. gene conversion events. Hum Mol Genet 2012; 21:2029-382229144310.1093/hmg/dds01922291443
  60. 21. Petes TD Meiotic recombination hot spots and cold spots. Nat Rev
  61. Genet 2001; 2:360-910.1038/3507207811331902
  62. 22. May CA, Shone AC, Kalaydjieva L, Sajantila A, Jeffreys AJ. Crossover
  63. clustering and rapid decay of linkage disequilibrium in the
  64. Xp/Yp pseudoautosomal gene SHOX. Nat Genet 2002 31:272-5.10.1038/ng91812089524
  65. 23. Kauppi L, Jeffreys AJ, Keeney S. Where the crossovers are: recombination
  66. distributions in mammals. Nat Rev Genet 2004; 5:413-2410.1038/nrg134615153994
  67. 24. Jeffreys AJ, Neumann R. The rise and fall of a human recombination
  68. hot spot. Nat Genet 2009; 41:625-91934998510.1038/ng.346267827919349985
  69. 25. Neumann R, Jeffreys AJ. Polymorphism in the activity of human
  70. crossover hotspots independent of local DNA sequence variation.16543360
  71. 2006; 15:1401-11.
  72. 26. Ptak SE, Voelpel K, Przeworski M. Insights into recombination from
  73. patterns of linkage disequilibrium in humans. Genetics 2004;
  74. 167:387-97
  75. 27. Ardlie KG, Kruglyak L, Seielstad M. Patterns of linkage disequilibrium
  76. in the human genome. Nat Rev Genet 2002; 3:299-3091196755410.1038/nrg77711967554
  77. 28. Grey C, Clément JA, Buard J, Leblanc B, Gut I, Gut M, Duret L, de
  78. Massy B. In vivo binding of PRDM9 reveals interactions with noncanonical
  79. genomic sites. Genome Res 2016; 4:580-590.
  80. 29. Striedner Y, Schwarz T, Welte T, Futschik A, Rant U, Tiemann-Boege
  81. I. The long zinc finger domain of PRDM9 forms a highly stable
  82. and long-lived complex with its DNA recognition sequence
  83. 2017; 2:155-172.
  84. 30. Ponting CP. What are the genomic drivers of the rapid evolution of
  85. PRDM9? Trends Genet 2011; 27:165-7110.1016/j.tig.2011.02.00121388701
Language: English
Page range: 319 - 331
Published on: Oct 27, 2017
Published by: European Biotechnology Thematic Network Association
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2017 Mahmut C. Ergören, Rita Neumann, Ingrid Berg, Alec J. Jeffreys, published by European Biotechnology Thematic Network Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.