Interferon Gamma Release Assays in Patients with Respiratory Isolates of Non-Tuberculous Mycobacteria – a Preliminary Study

Sex	No of pts	Age Median (range)	BMI Median (range)	Number of patients with certain coexisting disease
Sex	No of pts	Age Median (range)	BMI Median (range)	COPD	ILD or GPA	CTD	CF	Npl	Others^*
Males	16	58.5 (28–75)	24.9 (19.5–38.9)	5	3	0	0	3	5
Females	23	62 (29–85)	23.8 (16.2–37.3)	5	6	4	2	2	4
Total	39	61 (27–85)	24.3 (15–38.9)	10	9	4	2	5	9

1 COPD – chronic obstructive pulmonary disease; ILD – interstitial lung disease; GPA – granulomatosis with polyangiitis; CTD – connective tissue disease; CF – cystic fibrosis; npl – neoplasm; BMI – body mass index

2* Diabetes (2), hypothyreosis (1), lung aspergilloma (1), renal insufficiency (1), bronchiectasis (2), actinomycosis (1), lung cirrhosis (1), lobar pulmonary artery agenesis (1), trombofilia (1)

Table II

IGRAs results according to the NTM species.

Species	IGRA (+)	IGRA (−)	Total
M. kansasii	2 (22%)	7	9
M. avium	0	7	7
M. gordonae	0	6	6
M. chimaera	0	5	5
M. xenopi	0	5	5
M. fortuitum	1 (33%)	2	3
M. szulgai	0	1	1
M. abscessus	0	1	1
M. mucogenicum	0	1	1
M. smegmatis	0	1	1
Total	3 (8%)	36	39

Table III

IGRAs result according to patients’ age.

Age (years)	25–44	45–59	≥ 60	Total
IGRAs (+)	0	0	3 (14%)	3
IGRAs (−)	11	8	17	36
Total	11	8	20	39

Table IV

The IGRAs results according to radiologic signs of past tuberculosis.

Chest CT	IGRA (+)	IGRA (−)	Total
Past tb signs	3 (18%)	14 (82%)	17
No past tb signs	0 (0%)	22	22
Total	3	36	39

1 CT – computed tomography, tb – tuberculosis

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DOI: https://doi.org/10.21307/pjm-2019-002 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331

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Language: English

Page range: 15 - 19

Published on: Mar 27, 2019

Published by: Polish Society of Microbiologists

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

interferon gamma release,

non-tuberculous mycobacteria,

Mycobacterium kansasii,

latent tuberculosis infection

Related subjects:

Life sciences,

Microbiology and virology

© 2019 EWA AUGUSTYNOWICZ-KOPEĆ, IZABELA SIEMION-SZCZEŚNIAK, ANNA ZABOST, DOROTA WYROSTKIEWICZ, DOROTA FILIPCZAK, KARINA ONISZH, DARIUSZ GAWRYLUK, ELŻBIETA RADZIKOWSKA, DAMIAN KORZYBSKI, MONIKA SZTURMOWICZ, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 68 (2019): Issue 1 (March 2019)