Have a personal or library account? Click to login
Brucella – Virulence Factors, Pathogenesis and Treatment Cover

Brucella – Virulence Factors, Pathogenesis and Treatment

Polish Journal of Microbiology
Volume 67 (2018): Issue 2 (June 2018)
By: PATRYCJA GŁOWACKA,  DOROTA ŻAKOWSKA,  KATARZYNA NAYLOR,  MARCIN NIEMCEWICZ and  AGATA BIELAWSKA-DRÓZD  
Open Access
|Jun 2018

Figures & Tables

Fig. 1.

Mammalian cell invasion and intracellular trafficking.Smooth Brucella invasion into a cell by lipid rafts and acquisition of Rab5 and EEA1 markers – early BCV. β-1,2-glucans present in mature BCV and modification of lipid rafts. Then, the transient BCV interacts with lysosomes, T4SS is activated and it regulates intracellular trafficking from autophagosome to endoplasmatic reticulum (BCV acquires LAMP1 and Sec61β markers – late BCV – occurs only in epithelial cells). BCV acquires the endoplasmic reticulum markers (calnexin, calreticulin and Sec61-β) and the Brucella replicates. Rough Brucella organisms do not penetrate cell by lipid rafts, and therefore is exterminated.
Mammalian cell invasion and intracellular trafficking.Smooth Brucella invasion into a cell by lipid rafts and acquisition of Rab5 and EEA1 markers – early BCV. β-1,2-glucans present in mature BCV and modification of lipid rafts. Then, the transient BCV interacts with lysosomes, T4SS is activated and it regulates intracellular trafficking from autophagosome to endoplasmatic reticulum (BCV acquires LAMP1 and Sec61β markers – late BCV – occurs only in epithelial cells). BCV acquires the endoplasmic reticulum markers (calnexin, calreticulin and Sec61-β) and the Brucella replicates. Rough Brucella organisms do not penetrate cell by lipid rafts, and therefore is exterminated.
DOI: https://doi.org/10.21307/pjm-2018-029 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
Journal RSS Feed
Language: English
Page range: 151 - 161
Submitted on: Oct 17, 2017
|
Accepted on: Feb 28, 2018
|
Published on: Jun 30, 2018
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Brucella,
endoplasmic reticulum,
macrophage,
replication,
virulence factors
Related subjects:
Life sciences,
Microbiology and virology

© 2018 PATRYCJA GŁOWACKA, DOROTA ŻAKOWSKA, KATARZYNA NAYLOR, MARCIN NIEMCEWICZ, AGATA BIELAWSKA-DRÓZD, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Previous articleVolume 67 (2018): Issue 2 (June 2018)Next article