Summary of recommendations data on lacosamide and levetiracetam use in renal replacement therapy
| Renal replacement therapy | Lacosamide | Levetiracetam |
|---|---|---|
| Peritoneal dialysis | No data | With a dose of 1000 mg daily, a trough concentration at least at the upper limit of the therapeutic range may result |
| Intermittent haemodialysis | 100 mg daily with a supplementary dose of 150 mg post-haemodialysis may result in concentrations in the therapeutic range | 500 mg daily with a supplementary dose of 750 mg post-haemodialysis may result in subtherapeutic trough levels. A dose of 1000 mg twice/day may be more sufficient. |
| Continous venovenous haemofiltration | Whether 200 mg twice/day results in trough concentrations, at least in the lower therapeutic range, depends on the replacement rate used | 1000 mg every 12 hours may generate a trough concentration in the lower therapeutic range. |