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The influence of clinical and immune variables on psychopathological syndromes in partial epilepsies in relation to handedness Cover

The influence of clinical and immune variables on psychopathological syndromes in partial epilepsies in relation to handedness

Journal of Epileptology
Volume 27 (2019): Issue 1 (February 2019)
By: Vladimir V. Kalinin,  Elena V. Zheleznova,  Kirill Y. Subbotin,  Natalia G. Yermakova,  Anna A. Zemlyanaya and  Lyudmila V. Sokolova  
Open Access
|Sep 2019

Figures & Tables

The rank Spearman correlations between frequency of seizures of different semiotics and SCL-90 constructs in group of right-handers

VariableFocal seizures (FS)Focal sensory seizures (FSS)Focal motor seizures (FMS)Focal seizures with impaired awareness (FSIA)Focal to bilateral tonic-clonic seizures (FBTCS)NHS3
Somatization (SCL-90)− 0.029− 0.111− 0.044   0.000− 0.039   0.137
Obsession (SCL-90)− 0.024− 0.035   0.031   0.065− 0.112   0.069
Interpersonal sensitivity (SCL-90)   0.025− 0.004   0.042   0.164− 0.064   0.150
Depression (SCL-90)   0.065   0.057   0.106− 0.023− 0.043− 0.016
Anxiety (SCL-90)− 0.027− 0.043   0.004   0.010− 0.147   0.169
Hostility (SCL-90)   0.138   0.196   0.284р = 0.045   0.007   0.016   0.082
Phobic anxiety (SCL-90)− 0.160− 0.144− 0.128− 0.077− 0.128− 0.069
Paranoid ideations (SCL-90)− 0.086− 0.071   0.000   0.087− 0.064   0.119
Psychoticism (SCL-90)− 0.107− 0.126− 0.047− 0.028− 0.088   0.086

The rank Spearman correlations between immune variables and SCL-90 constructs in group of left-handers

VariableT-lymph.CD3+CD4+CD3+CD8+T-NKB-lymph.NKCD4/CD8 ratio
Somatization (SCL-90)− 0.612− 0.099− 0.291− 0.313   0.942р = 0.002− 0.122   0.209
Obsessions (SCL-90)− 0.128   0.529− 0.735− 0.424   0.107   0.218   0.780р = 0.039
Interpersonal sensitivity (SCL-90)   0.249   0.822р = 0.023− 0.763р = 0.046− 0.032− 0.152− 0.133   0.800р = 0.031
Depression (SCL-90)− 0.307   0.493− 0.796р = 0.032− 0.409   0.417   0.088   0.834р = 0.020
Anxiety (SCL-90)− 0.241   0.197− 0.429− 0.109   0.496− 0.144   0.470
Aggression (SCL-90)− 0.303   0.637− 0.954р = 0.001− 0.515   0.115   0.432   0.925р = 0.003
Phobic anxiety (SCL-90)− 0.433   0.241− 0.625− 0.262   0.441   0.194   0.657
Paranoid ideations (SCL-90)− 0.074   0.659− 0.829р = 0.021− 0.265   0.218− 0.023   0.873р = 0.010
Psychoticism (SCL-90)− 0.207   0.682− 0.897р = 0.006− 0.518   0.459   0.074   0.913р = 0.004

The rank Spearman correlations between frequency of seizures of different semiotics and SCL-90 constructs in group of left-handers

VariableFocal seizures (FS)Focal sensory seizures (FSS)Focal motor seizures (FMS)Focal seizures with impaired awareness (FSIA)Focal to bilateral tonic-clonic seizures (FBTCS)NHS3
Somatization (SCL-90)   0.069   0.074− 0.350   0.406   0.444   0.669
Obsession (SCL-90)− 0.110− 0.116− 0.093   0.876р = 0.01   0.875р = 0.01   0.651
Interpersonal sensitivity (SCL-90)− 0.708− 0.710   0.733   0.426   0.444   0.620
Depression (SCL-90)− 0.403− 0.398   0.158   0.947р = 0.001   0.913р = 0.004   0.823р = 0.023
Anxiety (SCL-90)− 0.071− 0.080− 0.015   0.833р = 0.02   0.915р = 0.004   0.769р = 0.043
Aggression (SCL-90)− 0.528− 0.521   0.024   0.686   0.616   0.662
Phobic anxiety (SCL-90)− 0.337− 0.336− 0.041   0.975р = 0.000   0.973р = 0.000   0.762р = 0.047
Paranoid ideations (SCL-90)− 0.412− 0.416   0.287   0.871р = 0.011   0.899р = 0.006   0.858р = 0.013
Psychoticism (SCL-90)− 0.470− 0.459   0.356   0.749   0.690   0.847р = 0.016

Comparison of mean values of seizure frequency of different semiotics and immune variables in groups of left-handers and right-handers

VariableLeft-handersRight-handersSignificance
Focal seizures (FS)154.71 ± 272.51  18.41 ± 46.91p = 0.000
Focal sensory seizures (FSS)150.00 ± 275.38  15.44 ± 45.72p = 0.000
Focal motor seizures (FMS)  11.86 ± 20.55    7.66 ± 40.21n.s.
Focal seizures with impaired awareness (FSIA)    8.71 ± 22.62  14.65 ± 36.86n.s.
Focal to bilateral tonic-clonic seizures (FBTCS)    9.57 ± 17.48  14.98 ± 22.39n.s.
NHS3  16.71 ± 12.78  13.15 ± 8.67n.s.
T-lymphocytes  77.63 ± 5.19  73.97 ± 6.60n.s.
T-helpers CD3+CD4  46.59 ± 8.94  46.59 ± 6.71n.s.
T-cytotoxic (CD3+CD8+)  28.87 ± 7.51  25.62 ± 6.22n.s.
T-NK (CD3+CD16+CD56+)    9.29 ± 5.91    6.01 ± 4.16n.s.
B-lymphocytes (CD3+CD19+)  10.24 ± 3.02  12.62 ± 4.97n.s.
Natural Killers (CD3-CD16+CD+56)    9.81 ± 3.20  11.69 ± 5.69n.s.
Regulatory index (CD4/CD8) ratio    1.79 ± 0.79    1.97 ± 0.65n.s.

Comparison of psychopathological variables in patients with left-handedness and right-handedness

VariableLeft-handed Patients (N = 7)Right-handed Patients (N = 59)Significance
Somatization SCL-90)    5.57 ± 3.69    7.15 ± 6.18N.S.
Obsession (SCL-90)    6.14 ± 4.45    8.34 ± 6.47N.S.
Sensitivity (SCL-90)    4.71 ± 2.43    8.06 ± 6.85p = 0.018
Depression (SCL-90)    6.14 ± 5.55    9.47 ± 8.68N.S.
Anxiety (SCL-90)    5.00 ± 2.65    5.59 ± 6.01N.S.
Aggression (SCL-90)    2.86 ± 2.67    5.14 ± 4.33N.S.
Phobia (SCL-90)    1.43 ± 2.07    3.45 ± 3.98N.S.
Paranoid (SCL-90)    3.00 ± 3.06    4.00 ± 3.80N.S.
Psychoticism (SCL-90)    2.57 ± 2.64    3.40 ± 4.30N.S.
Total Score (SCL-90)  37.43 ± 23.96  46.47 ± 31.47N.S.

The rank Spearman correlations between immune variables and SCL-90 constructs in group of right-handers

VariableT-lymph.CD3+CD4+CD3+CD8+T-NKB-lymph.NKCD4/CD8 ratio
Somatization (SCL-90)− 0.209− 0.089− 0.109− 0.063− 0.020   0.169   0.040
Obsessions (SCL-90)− 0.228   0.000− 0.232− 0.078− 0.010   0.175   0.182
Interpersonal sensitivity (SCL-90)− 0.169− 0.006− 0.141− 0.105− 0.090   0.173   0.145
Depression (SCL-90)− 0.169− 0.045− 0.108− 0.159− 0.023   0.123   0.085
Anxiety (SCL-90)− 0.172− 0.112− 0.023− 0.153− 0.026   0.124− 0.023
Aggression (SCL-90)− 0.119   0.074− 0.184− 0.202   0.063   0.061   0.195
Phobic anxiety (SCL-90)− 0.043   0.095− 0.188− 0.211   0.006− 0.027   0.187
Paranoid ideations (SCL-90)− 0.208− 0.006− 0.187− 0.058− 0.070   0.185   0.154
Psychoticism (SCL-90)− 0.271р=0.05− 0.043− 0.199− 0.213− 0.021   0.244   0.104
DOI: https://doi.org/10.21307/joepi-2019-005 | Journal eISSN: 2299-9728 | Journal ISSN: 2300-0147
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Language: English
Page range: 17 - 25
Submitted on: Apr 3, 2019
|
Accepted on: Jun 19, 2019
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Published on: Sep 12, 2019
Published by: The Foundation of Epileptology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
epilepsy,
seizure frequency,
immunity variables,
psychopathological constructs
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Neurology,
Pharmacology, toxicology,
Pharmacy,
Clinical pharmacy

© 2019 Vladimir V. Kalinin, Elena V. Zheleznova, Kirill Y. Subbotin, Natalia G. Yermakova, Anna A. Zemlyanaya, Lyudmila V. Sokolova, published by The Foundation of Epileptology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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