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Long-term offspring epilepsy outcomes following planned assisted homebirth versus hospital birth Cover

Long-term offspring epilepsy outcomes following planned assisted homebirth versus hospital birth

Open Access
|Feb 2018

Figures & Tables

Figure 1.

Death rates of 230 patients with childhood onset epilepsy. Black line: homebirths (n = 29); grey line: hospital births (n = 201).
Death rates of 230 patients with childhood onset epilepsy. Black line: homebirths (n = 29); grey line: hospital births (n = 201).

Figure 2.

Five-year terminal remission rates of 230 patients with childhood-onset epilepsy by birthplace. Black line: homebirths (n = 29); grey line: hospital births (n = 201).
Five-year terminal remission rates of 230 patients with childhood-onset epilepsy by birthplace. Black line: homebirths (n = 29); grey line: hospital births (n = 201).

Figure 3.

Ten-year terminal remission rates of 230 patients with childhood-onset epilepsy by birthplace. Black line: homebirths (n = 29); grey line: hospital births (n = 201).
Ten-year terminal remission rates of 230 patients with childhood-onset epilepsy by birthplace. Black line: homebirths (n = 29); grey line: hospital births (n = 201).

Univariate and multivariable analyses for predictors of seizure outcome in homebirths vs hospital births

UnivariateaMultivariableb
HR(95% CI)p-valueHR(95% CI)
5YTR, 2 years off-AEDs
Home birth1.1(0.6–2.0)0.8541.4(0.8–2.5)0.269
Abnormal birth0.5(0.3–0.8)0.0020.5(0.3–0.7)0.002
Abnormal pregnancy0.8(0.5–1.3)0.432
Cognitive disability in 1st degree relatives1.0(0.6–1.6)0.993
Clustering of seizures0.8(0.5–1.5)0.510
10YTR, 5years off-AEDs
Home birth1.2(0.6–2.2)0.5881.6(0.9–2.9)0.123
Abnormal birth0.4(0.3–0.7)0.0020.4(0.3–0.7)0.001
Abnormal pregnancy0.8(0.5–1.4)0.497
Cognitive disability in 1st degree relatives1.0(0.6–1.6)0.939
Clustering of seizures1.0(0.5–1.7)0.880

Univariate and multivariable analyses for predictors of long-term survival in homebirths vs hospital births

UnivariateaMultivariableb
HR(95% CI)p-valueHR(95% CI)
Death
Home birth1.5(0.8–2.7)0.2351.3(0.7–2.5)0.391
Clustering of seizures2.0(1.2–3.5)0.0112.0(1.1–3.3)0.014
Abnormal birth1.3(0.8–2.1)0.382
Abnormal pregnancy1.3(0.7–2.1)0.466
Cognitive disability in 1st degree relatives0.8(0.4–1.6)0.576
DOI: https://doi.org/10.21307/joepi-2018-001 | Journal eISSN: 2299-9728 | Journal ISSN: 2300-0147
Language: English
Page range: 7 - 14
Submitted on: Jan 9, 2018
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Accepted on: Jan 16, 2018
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Published on: Feb 13, 2018
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2018 Matti Sillanpaa, Maiju M. Saarinen, Päivi Polo-Kantola, published by The Foundation of Epileptology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.