The Cromer blood group system: an update

Figures & Tables

High-prevalence antigen number	Name	Low-prevalence antigen number	Name	Nucleotide change	Exon	Amino acid change	Reference	rs number*	Low-prevalence antigen identified in	gnomAD^† frequency of the low-prevalence allele (>0.01%)
CROM2	_Tc ^a	CROM3	Tc^b	c.155G>T	2	p.Arg52Leu	2	rs28371588	African Americans	African 2.6%Latin American 0.1%
		CROM4	Tc^c	c.155G>C		p.Arg52Pro	4		Europeans	European 0.03%
CROM9	WES^b	CROM8	WES^a	c.245T>G	2	p.Leu82Arg	4	rs147474393	African Americans, Finns	African 0.3%Finn 0.4%

ISBT allele name	Nucleotide change	Exon	Amino acid change	Reference	rs number^†	Null phenotype identified in	Occurrence in gnomAD^‡
CROM01N.04*	c.366 367insA	3	p.Thr123Asnfs*6	819	No rs	Moroccans
CROM01N.05*	c.148G>T	2	p.Glu50Ter	13	rs773074921	Pakistanis	3/30,616 alleles in South Asian population only
CROM01N.06*	c.639G>A	5	p.Trp213Ter	9	rs1391706310	Thais	3/18,392 alleles in East Asian population only
Not assigned	c.149_150delAAinsCCTT	2	p.Glu50Alafs*12	19	rs1135402916	Turks	No data
	c.109delG	2	p.Gly37Alafs*24		rs1135402915	Turks, Syrians	No data
	c.800G>C	6	p.Cys267Ser		rs1135402917	Turks	No data
	c.287-1G>A	3	Exon skipping		rs1135402918	Turks	No data

Number	Name	Nucleotide change	Exon	Amino acid change	Reference	rs number*	Negative phenotype identified in	gnomAD^† frequency of the variant allele (≥0.01%)
CROM1	Cr^a	c.679G>C	6	p.Ala227Pro	2	rs60822373	African Americans	African 2%
CROM5	Dr^a	c.596C>T	5	p.Ser199Leu	3	rs1135402914	Uzbekistani Jewish, Japanese	None
CROM6	Es^a	c.239T>A	2	p.Ile80Asn	4	rs776347919	Mexicans, African Americans	None
CROM10	UMC	c.749C>T	6	p.Thr250Met	5	rs566298946	Japanese	East Asian 0.1%
CROM11	GUTI	c.719G>A	6	p.Arg240His	6	rs199705465	Native Chileans(5.3%)	Finn 0.02%
CROM12	SERF	c.647C>T	5	p.Pro216Leu	7	rs144692928	Thais	South Asian 0.1%East Asian 0.02%African 0.018%
CROM13	ZENA	c.726T>G	6	p.His242Gln	7	rs769586650	Turkish Syrians	None
CROM14	CROV	c.466G>A	3	p.Glu156Lys	7	No rs	Croatians	Data not available
CROM15	CRAM	c.740A>G	6	p.Gln247Arg	7	No rs	Somalians	Data not available
CROM16	CROZ	c.389G>A	3	p.Arg130His	8	rs756646491	Australians	None
CROM17	CRUE	c.650T>G	5	p.Leu217Trp	9	rs567156112	Thais	East Asian 0.1%(Vietnamese 1%)
CROM18	CRAG	c.173A>G	2	p.Asp58Gly	10	No rs	Greeks	Data not available
CROM19	CROK	c. 245T>C	2	p.Leu82Pro	11	No rs	Israeli Druze	Data not available
CROM20	CORS	c.713G>A	6	p.Gly238Glu	12	No rs	French Corsicans	Data not available