A second example of anti-Esa, an antibody to a high-incidence Cromer antigen

Reid, M.E.; Marfoe, R.A.; Mueller, A.L.; Arndt, P.A.; Sausais, L.; Spruell, P.

doi:10.21307/immunohematology-2019-760

Abstract

A blood sample contained an antibody to a high-incidence antigen that reacted with all red blood cells (RBCs) tested by the indirect antiglobulin test (IAT). The antibody reacted with papain-, ficin-, and trypsin-treated RBCs, but not with α-chymotrypsin-treated RBCs. This pattern of reactivity suggested the possibility that the antibody was recognizing an antigen in the Cromer blood group system. Tests against RBCs deficient in decay-accelerating factor (which carries the Cromer antigens) were weakly positive. Tests with antibodies to high-incidence Cromer antigens and with RBCs lacking high-incidence Cromer antigens led to identification of the second example of anti-Es^a in an Es(a-) person. The antibody was IgGl and reacted by the IAT to a titer of 64. The monocyte monolayer assay indicated potential clinical significance of this antibody in relation to transfusion.

References

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A second example of anti-Esa, an antibody to a high-incidence Cromer antigen

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