Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion

Chan, D.; Poole, G.D.; Binney, M.; Hamon, M.D.; Copplestone, J.A.; Prentice, A.G.

doi:10.21307/immunohematology-2019-751

Abstract

Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wr^b that caused severe hemolysis that resulted in death. Immunohematology 1996;12:80–83.

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Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion

Abstract

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