Quantitation of red cell-bound immunoglobulins and complement in lymphoma patients

Podberezin, M.; Levina, A.; Romanova, L.; Margolin, O.; Nasibov, O.; Pivnik, A.V.

doi:10.21307/immunohematology-2019-597

Abstract

Quantitative ELISA may be useful for determining the amount of red blood cell (RBC)-associated immunoglobulins (Igs) in patients with autoimmune hemolytic anemia (AIHA). In idiopathic AIHA, there is about 20 times more RBC-associated IgG and complement than in normal persons. In patients with low-grade lymphomas (particularly, B-CLL and splenic marginal zone lymphoma) autoimmune hemolysis is a component of their anemia. In highgrade malignant lymphomas (i.e, diffuse large B-cell lymphoma and peripheral T-cell lymphoma), as well as in Hodgkin’s disease, autoimmune hemolysis contributes little, if any, anemia. The quantitative ELISA for RBC-associated IgG and complement is useful for following the effects of treatment in patients with immune hemolysis. Immunohematology 2000; 16:147–153.

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Quantitation of red cell-bound immunoglobulins and complement in lymphoma patients

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