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The Rh blood group system: the first 60 years of discovery Cover

The Rh blood group system: the first 60 years of discovery

By: C. Lomas-Francis and  M. E. Reid  
Paid access
|Nov 2020

References

  1. Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications, 1998.
  2. Daniels G. Human blood groups. Oxford, England: Blackwell Science, 1995.
  3. Race RR, Sanger R. Blood groups in man. 6th ed. Oxford, England: Blackwell Scientific Publications, 1975.
  4. Huang C-H. Molecular insights into the Rh protein family and associated antigens. Current Opinion in Hematology 1997;4:94–103.10.1097/00062752-199704020-00004
  5. Cartron J-P, Bailly P, Le van Kim C, et al. Insights into the structure and function of membrane polypeptides carrying blood group antigens. Vox Sang 1998; 74: (Suppl 2):29-64.10.1111/j.1423-0410.1998.tb05397.x
  6. Avent ND, Reid ME. The Rh blood group system: a review. Blood 2000; 95:375–87.10.1182/blood.V95.2.375
  7. Daniels GL, Anstee DJ, Cartron J-P, et al. Terminology for red cell surface antigens. ISBT working party Oslo report. Vox Sang 1999; 77:52–7.8. Tippett P. A speculative model for the Rh blood groups. Ann Hum Genet 1986; 50:241–7.10.1111/j.1469-1809.1986.tb01045.x
  8. Smythe JS, Avent ND, Judson PA, Parsons SF, Martin PG, Anstee DJ. Expression of RH D and R HC E gene products using retroviral transduction of K562 cells establishes the molecular basis of Rh blood group antigens. Blood 1996;87:2968–73.10.1182/blood.V87.7.2968.bloodjournal8772968
  9. Mouro I, Colin Y, Chérif-Zahar B, Cartron J-P, Le van Kim C. Molecular genetic basis of the human Rhesus blood group system. Nature Genet 1993; 5:62–510.1038/ng0993-62
  10. Carritt B, Kemp TJ, Poulter M. Evolution of the human RH (rhesus) blood group genes:a 50 year old prediction (partially) fulfilled. Hum Mol Genet 1997; 6:843–50.10.1093/hmg/6.6.843
  11. Okuda H, Suganuma H, Tsudo N, Omi T, Iwamoto S, Kajii E. Sequence analysis of the spacer region between the R H D and R H C E genes. Biochem Biophys Res Commun 1999;263:378–83.10.1006/bbrc.1999.1370
  12. Chérif-Zahar B, Le van Kim C, Rouillac C, Raynal V, Cartron J-P, Colin Y. Organization of the gene (RH CE) encoding the human blood group RhCcEe antigens and characterization of the promoter region. Genomics 1994; 19:68–74.10.1006/geno.1994.1014
  13. Hartel-Schenk S, Agre P. Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex. J Biol Chem 1992;267:5569–74.10.1016/S0021-9258(18)42803-7
  14. Huang C-H. The human Rh50 glycoprotein gene: structural organization and associated splicing defect resulting in Rhnull disease. J Biol Chem 1998; 273:2207–13.10.1074/jbc.273.4.2207
  15. Moore S, Green C. The identification of specific Rhesus polypeptide blood group ABH-active glycoprotein complexes in the human red-cell membrane. Biochem J 1987;244:735–41.10.1042/bj2440735
  16. Mallinson G, Anstee DJ, Avent ND, et al. Murine monoclonal antibody MB-2D10 recognizes Rh-related glycoproteins in the human red cell membrane. Transfusion 1990; 30:222–5.10.1046/j.1537-2995.1990.30390194341.x
  17. Matassi G, Chérif-Zahar B, Pesole G, Raynal V, Cartron J-P. The members of the RH gene family (R H5 0 and RH 3 0) fol lowed different evol utionary pathways. J Mol Evol 1999;48:151–9.10.1007/PL00006453
  18. Liu W, Smythe JS, Scott ML, et al. Site-directed mutagenesis of the human D antigen:definition of D epitopes on the sixth external domain of the D protein expressed on K562 cells. Transfusion 1999;39:17–25.10.1046/j.1537-2995.1999.39199116890.x
  19. Green FA. Erythrocyte membrane sulfhydryl groups and Rh antigen activity. Immunochemistry 1967; 4:247–57.10.1016/0019-2791(67)90186-3
  20. Suyama K, Lunn R, Goldstein J. Red cell surface cysteine residue (285) of D polypeptide is not essential for D antigenicity. Transfusion 1995;35:653–9.10.1046/j.1537-2995.1995.35895357896.x7631405
  21. Smythe JS, Anstee DJ. K562 cells expressing RhD polypeptide with a Cys285 to Ala mutation have a normal D antigen (abstract). Transfus Med 1997; 7 (Suppl 1):29.
  22. Westhoff CM, Silberstein LE, Sipherd B, et al. Altered “e”antigen expression associated with 16Cys in exon 1 of the RH ce gene (abstract). Transfusion 1998; 38 (Suppl):64S.
  23. Huang C-H, Reid ME, Chen Y, et al. Deletion of Arg229 in RhCE polypeptide alters expression of RhE and CE-associated Rh6 (abstract). Blood 1997; 90 (Suppl 1):272a.
  24. Daniels GL, Faas BHW, Green CA, et al. The VS and V blood group polymorphisms in Africans: a serological and molecular analysis. Transfusion 1998; 38: 951–8.10.1046/j.1537-2995.1998.381098440860.x9767746
  25. Noizat-Pirenne F, Mouro I, Le Pennec P, et al. Evidence that serine at position 103 is not sufficient for complete C antigen expression (abstract). Transfusion 1999; 39 (Suppl):103S.
  26. Lomas C, Mougey R. Rh antigen D: variable expression in DVI phenotypes; a possible subdivision of category VI by a low- frequency antigen (abstract). Transfusion 1989; 29 (Suppl):14S.
  27. Westhoff CM, Silberstein LE, Wylie DE, et al. Characterization of the Rh locus of the New World c a p u chin (Cebus apella) monkey (ab s trac t). Transfusion 1998;38 (Suppl):102S.
  28. Faas BHW, Ligthart PC, Lomas-Francis C, Overbeeke MAM, von dem Borne AEGKr, van der Schoot CE. Involvement of Gly96 in the formation of the RH:26 epitope. Transfusion 1997;37:1123–30.10.1046/j.1537-2995.1997.37111298088040.x9426634
  29. Noizat-Pirenne F, Mouro I, Gane P, et al. Heterogeneity of blood group RhE variants revealed by serological analysis and molecular alteration of the R H CE gene and transcript. Br J Haematol 1998; 103:429–36.10.1046/j.1365-2141.1998.01004.x9827916
  30. Noizat-Pirenne F, Mouro I, Le Pennec P, et al. Molecular basis of category EIV variant phenotype (abstract). Transfusion 1999; 39 (Suppl):103S.
  31. Tippett P, Lomas-Francis C, Wallace M. The Rh antigen D: partial D antigens and associated low incidence antigens. Vox Sang 1996; 70:123–3110.1111/j.1423-0410.1996.tb01309.x
  32. Jones J, Scott ML, Voak D. Monoclonal anti-D specificity and Rh D structure: criteria for selection of monoclonal anti-D reagents for routine typing of patients and donors. Transfus Med 1995;5:171–84.10.1111/j.1365-3148.1995.tb00225.x
  33. Scott M. Rh serology—Coordinator’s report. Trans Clin Biol 1996; 6:333–7.10.1016/S1246-7820(96)80040-1
  34. Wagner FF, Gassner C, Eicher N, et al. Characterization of D category IV type IV, DFW, and DNB (abstract). Transfusion 1998; 38 (Suppl):63S.
  35. Jones J, Finning K, Mattock R, et al. The serological profile and molecular basis of a new partial D phe- notype, DHR. Vox Sang 1997; 73:252–6.10.1159/000461941
  36. Wagner FF, Gassner C, Müller TH, et al. Three molecular structures cause rhesus D category VI phenotypes with distinct immunohematological features. Blood 1998;91:2157–68.10.1182/blood.V91.6.2157
  37. Omi T, Takahashi J, Tsudo N, et al. The genomic organization of the partial D category DVa : the presence of a new partial D associated with the DVa phenotype. Biochem Biophys Res Commun 1999; 254:786–94.10.1006/bbrc.1998.0121
  38. Rios M, Storry JR, Hue-Roye K, Reid ME, Castilho LL, Pelegrino JJ. Incidence of partial D, DIIIa, in black donors as determined by PCR-RFLP analysis (abstract). Transfusion 1998; 38 (Suppl):63S.
  39. Rouillac C, Gane P, Cartron J, Le Pennec PY, Cartron J-P, Colin Y. Molecular basis of the altered expression of RhD in weak D(DU) and RhC/e in RN phenotype (abstract). Blood 1996; 87:4853–61.10.1182/blood.V87.11.4853.bloodjournal87114853
  40. Beckers EAM, Faas BHW, Overbeeke MAM, von dem Borne AEGKr, van Rhenen DJ, van der Schoot CE. Molecular aspects of the weak-D phenotype (abstract). Transfusion 1995; 35 (Suppl):50S.
  41. Wagner FF, Gassner C, Müller TH, et al. Molecular basis of weak D phenotypes. Blood 1999; 93:385–93.10.1182/blood.V93.1.385
  42. Okuda H, Kawano M, Iwamoto S, et al. The RH D gene is highly detectable in RhD-negative Japanese donors. J Clin Invest 1997; 100:373–9.10.1172/JCI119543
  43. Daniels G, Green C, Smart E. Differences between RhD-negative Africans and RhD-negative Europeans. Lancet 1997; 350:862–4.10.1016/S0140-6736(05)62031-4
  44. Daniels GL, Faas BHW, Green CA, et al. The VS and V blood group polymorphisms in Africans: a serological and molecular analysis. Transfusion 1998; 38:951–8.10.1046/j.1537-2995.1998.381098440860.x
  45. Sausais L, Øen R, Rios M, et al. DAK, a low incidence antigen shared by DIIIa and RN RBCs (abstract). Transfusion 1999; 39 (Suppl):79S.
  46. Cartron J-P, Agre P. Rh blood groups and Rh deficiency syndrome. Blood Cell Biochem 1995; 6:189–225.10.1007/978-1-4757-9537-0_6
  47. Eye rs SA, R i d g well K, M aw by W J, Tanner MJ. Topology and organization of human Rh (rhesus) blood group-related polypeptides. J Biol Chem 1994;269:6417–23.10.1016/S0021-9258(17)37388-X
  48. Beckmann R, Smythe J, Anstee D, Tanner M. Functional cell surface expression of band 3, the human red blood cell anion exchange protein (AE1), in K562 erythroleukemia cells: band 3 enhances the cell surface reactivity of Rh antigens. Blood 1998;92:4428–38.10.1182/blood.V92.11.4428
  49. Huang C-H, Chen Y, Reid ME, Seidl C. Rhnull disease: the amorph type results from a novel double mutation in R hC egene on D-negative background. Blood 1998;92:664–71.10.1182/blood.V92.2.664
  50. Huang C-H, Cheng G-J, Reid ME, Chen Y. Rhmod syn- drome:a family study of the translation-initiator mutation in the Rh50 glycoprotein gene. Am J Hum Genet 1999; 64:108–17.10.1086/302215
  51. Hyland CA, Chérif-Zahar B, Cowley N, et al. A novel single missense mutation identified along the R H 50 gene in a composite heterozygous Rhnull blood donor of the regulator type. Blood 1998; 91:1458–63.10.1182/blood.V91.4.1458
  52. Huang C-H, Lui Z, Cheng G, Chen Y. Rh50 glycoprotein gene and Rhnull disease:a silent splice donor is trans to a Gly279÷ Glu missense mutation in the conserved transmembrane segment. Blood 1998; 92:1776–84.10.1182/blood.V92.5.1776
  53. Chérif-Zahar B, Matassi G, Raynal V, et al. Rh-defi- ciency of the regulator type caused by splicing mutations in the human RH 5 0 gene. Blood 1998; 92:2535–40.10.1182/blood.V92.7.2535
  54. Marini A M, U rrestarazuA, B e a u wens R, André B. The Rh (rhesus) blood group polypeptides are related to NH4+ transporters. Trends in Biochemical Sciences 1997;22:460–1.10.1016/S0968-0004(97)01132-8
  55. Reid M, Yazdanbakhsh K. Molecular insights into blood groups and implications for blood transfusion. Current Opinion in Hematology 1998; 5:93–102.10.1097/00062752-199803000-000039570701
  56. Flegel W, Wagner F, Müller T, Gassner C. Rh phenotype prediction by DNA typing and its application to practice. Transfus Med 1998;8:281–302.10.1046/j.1365-3148.1998.00173.x9881423
DOI: https://doi.org/10.21307/immunohematology-2019-573 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 7 - 17
Published on: Nov 9, 2020
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 C. Lomas-Francis, M. E. Reid, published by American National Red Cross
This work is licensed under the Creative Commons License.