Red blood cell antigen changes in malignancy: case report and review

Winters, J.L.; Howard, D.S.

doi:10.21307/immunohematology-2019-533

Abstract

Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a patient in whom the expression of the Rh D and C antigens was lost due to the development of chronic myelogenous leukemia (CML). For this patient, this represented more than a blood bank curiosity but was of critical importance in determining further treatment of the leukemia.

The mechanisms behind changes in RBC antigens due to malignancy are reviewed for a number of antigens, antigen systems, and antigen collections. Previous case reports of RBC antigen changes due to malignancy are summarized.

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Red blood cell antigen changes in malignancy: case report and review

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