Red blood cell antigen changes in malignancy: case report and review

J.L. Winters; D.S. Howard

doi:10.21307/immunohematology-2019-533

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Red blood cell antigen changes in malignancy: case report and review

Immunohematology

Volume 17 (2001): Issue 1 (March 2001)

By: J.L. Winters and D.S. Howard

Paid access

|Oct 2020

Abstract

Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a patient in whom the expression of the Rh D and C antigens was lost due to the development of chronic myelogenous leukemia (CML). For this patient, this represented more than a blood bank curiosity but was of critical importance in determining further treatment of the leukemia.

The mechanisms behind changes in RBC antigens due to malignancy are reviewed for a number of antigens, antigen systems, and antigen collections. Previous case reports of RBC antigen changes due to malignancy are summarized.

References

Gale RP, Horowitz MM, Ash RC, et al. Identical-twin bone marrow transplants for leukemia. Ann Inter Med 1994;120:646–52.10.7326/0003-4819-120-8-199404150-00004
Search in Google Scholar Back to article
van Loghem JJ, Dorfmeier H, van der Hart M. Two A antigens with abnormal serological properties. Vox Sang 1957;2:16–24.10.1159/000478290
Search in Google Scholar Back to article
Kolins J, Holland PV, McGinniss MH. Multiple red cell antigen loss in acute granulocytic leukemia. Cancer 1978;42:2248–53.10.1002/1097-0142(197811)42:5<;2248::AID-CNCR2820420524>3.0.CO;2-T
Search in Google Scholar Back to article
Satheesh P, Thomas M, Rajan GB. Change in the ABO blood group phenotype. J Assoc Physicians India 1994;42:830.
Search in Google Scholar Back to article
Chiewsilp P, Atichartakarn V. Change of red cell B antigen in a leukemic patient. J Med Assoc Thailand 1981;64:413–7.
Search in Google Scholar Back to article
Yamada K, Yoshizaki Y, Fujii Y, et al. Concurrent ABO blood type change and erythrophagocytosis by leukemic cells in a case of acute myeloblastic leukemia. Acta Haematol Jpn 1985;48:1409–13.
Search in Google Scholar Back to article
van der Hart M, van der Veer M, van Loghem JJ. Change of blood group B in a case of leukemia. Vox Sang 1962;7:449–53.10.1159/000464801
Search in Google Scholar Back to article
Hoogstraten B, Rosenfield RE, Wasserman LR. Change of ABO blood type in a patient with leukemia.Transfusion 1961;1:32–5.10.1111/j.1537-2995.1961.tb00008.x
Search in Google Scholar Back to article
Crookston MC. Anomalous ABO, H, Ii phenotypes in disease. In: Garratty G, ed. Blood group antigens and disease.Arlington,VA:American Association of Blood Banks, 1983:67–84.
Search in Google Scholar Back to article
Yoshida A, Kumazaki T, Dave V, Blank J, Dzik WH. Suppressed expression of blood group B antigen and blood group galactosyltransferase in a preleukemic subject. Blood 1985;66:990–2.10.1182/blood.V66.4.990.990
Search in Google Scholar Back to article
Reid ME, Bird GW. Associations between human red cell blood group antigens and disease. Transfus Med Rev 1990;4:47–55.10.1016/S0887-7963(90)70247-7
Search in Google Scholar Back to article
Dobrovic A, O’Keefe D, Sage RE, Batchelder E. Imprinting and loss of ABO antigens in leukemia. Blood 1993;82:1684–5.10.1182/blood.V82.5.1684.bloodjournal8251684b
Search in Google Scholar Back to article
Kuhns WJ, Oliver RT, Watkins WM, Greenwell P. Leukemia-induced alterations of serum glycosyltransferase enzymes. Cancer Res 1980;40:268–75.
Search in Google Scholar Back to article
Salmon C. Blood group changes in preleukemic states. Blood Cells 1976;2:211–20.
Search in Google Scholar Back to article
Lopez M, Bonnet-Gajdos M, Reviron M, Janvier D, Huet M, Salmon C. An acute leukaemia augured before clinical signs by blood group antigen abnormalities and low levels of A and H blood group transferase activities in erythrocytes. Br J Haematol 1986;63:535–9.10.1111/j.1365-2141.1986.tb07531.x
Search in Google Scholar Back to article
Gold ER, Tovey GH, Benny WE, Lewis FJW. Changes in group A antigen in a case of leukaemia. Nature 1959;183:892–3.10.1038/183892a0
Search in Google Scholar Back to article
Treacy M, Geiger J, Goss MF. Substances in serum causing interference with blood group determination.Transfusion 1967;7:443–6.10.1111/j.1537-2995.1967.tb04883.x4965289
Search in Google Scholar Back to article
Levan A, Nichols WW, Hall B, Low B, Nilsson SB, Norden A. Mixture of Rh positive and Rh negative erythrocytes and chromosomal abnormalities in a case of polycythemia. Hereditas 1964;52:89–105.
Search in Google Scholar Back to article
Majsky A. Some cases of leukaemia with modifications of the D(Rh_o)-receptor. Neoplasma 1967;14:335–44.
Search in Google Scholar Back to article
Cooper B, Tishler PV, Atkins L, Breg WR. Loss of Rh antigen associated with acquired Rh antibodies and a chromosome translocation in a patient with myeloid metaplasia. Blood 1979;54:642–7.10.1182/blood.V54.3.642.642
Search in Google Scholar Back to article
Bracey AW, McGinniss MH, Levine RM, Whang-Peng J. Rh mosaicism and aberrant MNSs antigen expression in a patient with chronic myelogenous leukemia. Am J Clin Pathol 1983;79:397–401.10.1093/ajcp/79.3.3976402921
Search in Google Scholar Back to article
van Bockstaele DR, Berneman ZN, Muylle L, Cole-Dergent J, Peetermans ME. Flow cytometric analysis of erythrocytic D antigen density profile. Vox Sang 1986;51:40–6.10.1159/000461449
Search in Google Scholar Back to article
Mohandas V, Najfeld H, Gilbert P, Azar D, Tabrizi D. Loss and reappearance of Rh_o antigen in an individual with acute myelogenous leukemia (abstract).Transfusion 1993;33:24s.
Search in Google Scholar Back to article
Cherif-Zahar B, Bony V, Steffensen R, et al. Shift from Rh-positive to Rh-negative phenotype caused by a somatic mutation within the RHD gene in a patient with chronic myelocytic leukaemia. Br J Haematol 1998;102:1263–70.10.1046/j.1365-2141.1998.00895.x9753055
Search in Google Scholar Back to article
Tovey GH, Lockyer JW, Tierney RB. Changes in Rh grouping reactions in a case of leukaemia. Vox Sang 1961;6:628–31.10.1111/j.1423-0410.1961.tb03215.x13922189
Search in Google Scholar Back to article
Callender ST, Kay HE, Lawler SD, Millard RE, Sanger R, Tippett PA. Two populations of Rh groups together with chromosomally abnormal cell lines in the bone marrow. Br Med J 1971;1:131–3.10.1136/bmj.1.5741.13117951414992703
Search in Google Scholar Back to article
Habibi B, Lopez M, Salmon C. Two new cases of Rh mosaicism. Selective study of red cell populations. Vox Sang 1974;27:232–42.10.1111/j.1423-0410.1974.tb02413.x4213520
Search in Google Scholar Back to article
Mertens G, Gielis M, Muylle L, de Raedt S. Loss of D and C expression in chronic myelomonocytic leukemia.Transfusion 1997;37:880–1.10.1046/j.1537-2995.1997.37897424418.x9280340
Search in Google Scholar Back to article
Kolins J, Allgood JW, Burghardt DC, Klein HG, McGinniss MH. Modifications of B, I, i, and Lewis^b antigens in a patient with DiGuglielmo’s erythroleukemia.Transfusion 1980;20:574–7.10.1046/j.1537-2995.1980.20581034514.x6932779
Search in Google Scholar Back to article
Csato E, Vass E. Frequency of Lewis group substances in patients with cancer of stomach. Haematologia (Budap) 1989;22:55–9.
Search in Google Scholar Back to article
Schmidt PJ, Yokoyama M, McGinniss MH, Carbone PP. Effect of disease on an expression of blood group I. Bibl Haematol 1965;23:343–5.
Search in Google Scholar Back to article
Jenkins WJ, Marsh WL, Gold ER. Reciprocal relationship of antigens I and i in health and disease. Nature 1965;205:813.10.1038/205813a014283149
Search in Google Scholar Back to article
Giblett ER, Crookston MC. Agglutinability of red cells by anti-i in patients with thalassemia major and other haematological disorders. Nature 1964;201:1138–9.10.1038/2011138a014152804
Search in Google Scholar Back to article
Perkins HA, McIlroy M, Swanson J, Kadin M. Transient LW-negative red blood cells and anti-LW in a patient with Hodgkin’s disease. Vox Sang 1977;33:299–303.
Search in Google Scholar Back to article
Komatsu F, Kajiwara M. Transient depression of LW^a antigen with coincident production of anti-LW^a repeated in relapses of malignant lymphoma. Transfus Med 1996;6:139–43.10.1046/j.1365-3148.1996.d01-63.x8809962
Search in Google Scholar Back to article
Chown B, Kaita H, Lowen B, Lewis M. Transient production of anti-LW by LW-positive people. Transfusion 1971;11:220–2.10.1111/j.1537-2995.1971.tb04405.x4998711
Search in Google Scholar Back to article
37.Poole J, Williamson LM, Clark N, Black A. Loss of Lutheran and LW antigen expression in a patient with autoimmune thrombocytopenic purpura (ITP) (abstract).Transfusion 1991;31:38s. 38.de la Chapelle A, Vuopio P, Sanger R, Teesdale P. Monosomy-7 and the Colton blood-groups. Lancet 1975;2:817.
Back to article
Boetius G, Hustinx TW, Smits AP, Scheres JM, Rutten FJ, Haanen C. Monosomy 7 in two patients with a myeloproliferative disorder. Br J Haematol 1977;37:101–9.10.1111/j.1365-2141.1977.tb08815.x
Search in Google Scholar Back to article
Pasquali F, Bernasconi P, Casalone R, et al. Pathogenetic significance of “pure” monosomy 7 in myeloproliferative disorders. Analysis of 14 cases. Hum Genet 1982;62:40–51.10.1007/BF002956026961098
Search in Google Scholar Back to article
Telen MJ, Rao N, Udani M, Liao H-X, Haynes BF. The AnWj blood group antigen/Hemophilus influenzae receptor resides on a high-molecular weight protein expressed by CD44 transfectants. Clin Res 1993;41:161A.
Search in Google Scholar Back to article
Mannessier L, Rouger P, Johnson CL, Mueller KA, Marsh WL. Acquired loss of red-cell Wj antigen in a patient with Hodgkin’s disease. Vox Sang 1986;50:240–4.
Search in Google Scholar Back to article
Yomtovian R, Prince GM, Medof ME. The molecular basis for paroxysmal nocturnal hemoglobinuria. Transfusion 1993;33:852–73.10.1046/j.1537-2995.1993.331094054626.x8236430
Search in Google Scholar Back to article
Dunn DE, Tanawattanacharoen P, Boccuni P, et al. Paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure syndromes. Ann Intern Med 1999;131:401–8.10.7326/0003-4819-131-6-199909210-0000210498555
Search in Google Scholar Back to article
Cartron JP, Andreu G, Cartron J, Bird GW, Salmon C, Gerbal A. Demonstration of T-transferase deficiency in Tn-polyagglutinable blood samples. Eur J Biochem 1978;92:111–9.10.1111/j.1432-1033.1978.tb12728.x83233
Search in Google Scholar Back to article
Vengelen-Tyler V, ed. Technical manual. 13th ed. Bethesda, MD: American Association of Blood Banks, 1999.
Search in Google Scholar Back to article
Bird GW, Wingham J, Pippard MJ, Hoult JG, Melikian V. Erythrocyte membrane modification in malignant diseases of myeloid and lymphoreticular tissues. I. Tn-polyagglutination in acute myelocytic leukaemia. Br J Haematol 1976;33:289–94.10.1111/j.1365-2141.1976.tb03540.x1063594
Search in Google Scholar Back to article
Roxby DJ, Morley AA, Burpee M. Detection of the Tn antigen in leukaemia using monoclonal anti-Tn antibody and immunohistochemistry. Br J Haematol 1987;67:153–6.10.1111/j.1365-2141.1987.tb02319.x3479188
Search in Google Scholar Back to article
Roxby DJ, Pfeiffer MB, Morley AA, Kirkland MA. Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia. Transfusion 1992;32: 834–8.10.1046/j.1537-2995.1992.32993110755.x1471247
Search in Google Scholar Back to article
Ness PM, Garratty G, Morel PA, Perkins HA. Tn polyagglutination preceding acute leukemia. Blood 1979;54:30–4.10.1182/blood.V54.1.30.30
Search in Google Scholar Back to article
Bird GW, Wingham J, Richardson SG. Myelofibrosis, autoimmune haemolytic anaemia and Tn polyagglutinability. Haematologia (Budap) 1985; 18:99–103.
Search in Google Scholar Back to article