Practical aspects of investigating drug-induced immune hemolytic anemia due to cefotetan or ceftriaxone—a case study approach

Arndt, P.A.

doi:10.21307/immunohematology-2019-504

Abstract

In the 1970s, the most common causes of drug-induced immune hemolytic anemia were methyldopa and penicillin. Since 1990, the most common causes of drug-induced immune hemolytic anemia have been the second- and third-generation cephalosporins, cefotetan and ceftriaxone. Three case histories illustrate the common findings in the serologic investigation of immune hemolytic anemias due to these two drugs. Immunohematology 2002;18:27–32.

References

Garratty G, Postoway N, Schwellenbach J, McMahill PC. A fatal case of ceftriaxone (Rocephin)-induced hemolytic anemia associated with intravascular immune hemolysis. Transfusion 1991;31:176-9.10.1046/j.1537-2995.1991.31291142951.x
Search in Google Scholar Back to article
Garratty G, Nance S, Lloyd M, Domen R. Fatal immune hemolytic anemia due to cefotetan. Transfusion 1992;32:269-71.10.1046/j.1537-2995.1992.32392213813.x
Search in Google Scholar Back to article
Shulman IA, Arndt PA, MeGehee W, Garratty G. Cefotaxime-induced immune hemolytic anemia due to antibodies reacting in vitro by more than one mechanism. Transfusion 1990;30:263-6.10.1046/j.1537-2995.1990.30390194351.x
Search in Google Scholar Back to article
Arndt PA, Garratty G, Maranto LS, Wohl H. Immune hemolytic anemia associated with mefloquine (letter). Transfusion 1997;37:1220-1.10.1046/j.1537-2995.1997.37111298088058.x
Search in Google Scholar Back to article
Arndt PA, Wolf CF, Kripas CJ, Garratty G. First example of an antibody to ticarcillin; a possible cause of hemolytic anemia (abstract). Transfusion 1999;39(Suppl):47S.
Search in Google Scholar Back to article
Arndt PA, Garratty G, Hill J, Kasper M, Chandrasekaran V. Two cases of immune haemolytic anaemia associated with anti-piperacillin detected by the “immune complex” method. Vox Sang (in press).
Search in Google Scholar Back to article
Arndt PA, Leger RM, Garratty G. Serology of antibodies of second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin tests. Transfusion 1999;39:1239-46.10.1046/j.1537-2995.1999.39111239.x
Search in Google Scholar Back to article
Petz LD, Garratty G. Acquired immune hemolytic anemias. New York: Churchill Livingstone, 1980.
Search in Google Scholar Back to article
Spath P, Garratty G, Petz L. Studies on the immune response to penicillin and cephalothin in humans. II. Immunohematologic reactions to cephalothin administration. J Immunol 1971;107:860-9.10.4049/jimmunol.107.3.860
Search in Google Scholar Back to article
Branch DR, Sy Siok Hian AL, Petz LD. Mechanism of nonimmunologic adsorption of proteins using cephalosporin-coated red cells (abstract). Transfusion 1984;24(Suppl):415.
Search in Google Scholar Back to article
Garratty G, Arndt P, Nance S. Nonimmunological adsorption of proteins onto red cells treated with second and third generation cephalosporins (abstract). Transfusion 1994;34 (Suppl):69S.
Search in Google Scholar Back to article
Garratty G, Arndt PA. Positive direct antiglobulin tests and haemolytic anaemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Br J Haematol 1998;100:777-83.10.1046/j.1365-2141.1998.00615.x
Search in Google Scholar Back to article
Arndt PA, Leger RM, Garratty G. Reactivity of “last wash” elution controls in investigations of cefotetan antibodies (abstract). Transfusion 1999;39(Suppl):47S.
Search in Google Scholar Back to article
Löw B, Messeter L. Antiglobulin test in low-ionic strength salt solution for rapid antibody screening and cross-matching. Vox Sang 1974;26:53-61.10.1111/j.1423-0410.1974.tb02666.x
Search in Google Scholar Back to article
Leger RM, Arndt PA, Ciesielski DJ, Garratty G. Falsepositive eluate reactivity due to the low-ionic wash solution used with commercial acid-elution kits. Transfusion 1998;38:565-72.10.1046/j.1537-2995.1998.38698326336.x
Search in Google Scholar Back to article
Garratty G, Leger RM, Arndt PA. Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures. Am J Obstet Gynecol 1999;181:103-4.10.1016/S0002-9378(99)70443-6
Search in Google Scholar Back to article
Moallem HJ, Garratty G, Wakeham M, et al. Ceftriaxone-related fatal hemolysis in an adolescent with perinatally acquired human immunodeficiency virus infection. J Pediatr 1998;133:279-81.10.1016/S0022-3476(98)70236-7
Search in Google Scholar Back to article
Petersen BH, Graham J. Immunologic cross-reactivity of cephalexin and penicillin. J Lab Clin Med 1974;83:860-70.
Search in Google Scholar Back to article
Garratty G, Houston M, Petz LD, Webb M. Acute immune intravascular hemolysis due to hydrochlorothiazide. Am J Clin Pathol 1981;76:73-8.10.1093/ajcp/76.1.737258154
Search in Google Scholar Back to article
Shirey RS, Morton SJ, Lawton KB, et al. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol 1988;89:410-4.10.1093/ajcp/89.3.4103348176
Search in Google Scholar Back to article
Physicians’ Desk Reference. 54th ed. Montvale, NJ: Medical Economics Company, Inc., 1990.
Search in Google Scholar Back to article
Meyer O, Hackstein H, Hoppe B, Göbel F-J, Bein G. Fatal immune haemolysis due to a degradation product of ceftriaxone. Br J Haematol 1999;105: 1084-5.10.1046/j.1365-2141.1999.01434.x10554824
Search in Google Scholar Back to article
Seltsam A, Salama A. Ceftriaxone-induced immune haemolysis: two case reports and a concise review of the literature. Intensive Care Med 2000;26:1390-4.10.1007/s00134000059811089773
Search in Google Scholar Back to article

Practical aspects of investigating drug-induced immune hemolytic anemia due to cefotetan or ceftriaxone—a case study approach

Abstract

Paradigm

My account