HPA-1a/b (PlA1/A2, Zwa/b): the odyssey of an alloantigen system
By:
R.H Aster and P.J. Newman
Paid access
|Apr 2020References
- Zucker MB, Ley AB, Borrelli J, Mayer K, Firmat J. Thrombocytopenia with a circulating platelet agglutinin, platelet agglutinin, platelet lysin and clot retraction inhibitor. Blood 1959;14:148–61.
- van Loghem JjJ, Dorfmeijer H, Van Hart M, Schreuder F. Serological and genetical studies on a platelet antigen (Zw). Vox Sang 1959;4:161–9.
- Shulman NR, Aster RH, Leitner A, Hiller MC. Immunoreactions involving platelets. V. Posttransfusion purpura due to a complement-fixing antibody against a genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in “autoimmunity.” J Clin Invest 1961;40:1597–620.
- Shulman NR, Aster RH, Pearson HA, Hiller MC. Immunoreactions involving platelet. VI. Reactions of maternal isoantibodies responsible for neonatal purpura. Differentiation of a second platelet antigen system. J Clin Invest 1962;41:1059–69.
- Van Der Weerdt CM, Veenhoven-Vonriesz LE, Nijenhuis LE, Van Loghem J. The Zw blood group system in platelets. Vox Sang 1963;8:513–30.
- von dem Borne AE, Decary F. Nomenclature of platelet-specific antigens. Hum Immunol 1990;29: 1–2.
- Covas DT, Delgado M, Zeitune MM, Guerreiro JF, Santos SE, Zago MA. Gene frequencies of the HPA-1 and HPA-2 platelet antigen alleles among the Amerindians. Vox Sang 1997;73:182–4.
- Kim HO, Jin Y, Kickler TS, Blakemore K, Kwon OH, Bray PF. Gene frequencies of the five major human platelet antigens in African American, white, and Korean populations. Transfusion 1995;35:863–7.
- Chang YW, Mytilineos J, Opelz G, Hawkins BR. Distribution of human platelet antigens in a Chinese population. Tissue Antigens 1998;51: 391–3.
- Shulman NR, Jordan JV. Platelet immunology. In: Colman RW HJ, Marder VJ, Salzman EW, eds. Hemostasis and thrombosis. Philadelphia: JB Lippincott, 1987:452–529.
- Newman PJ, McFarland JG, Aster RH. Alloimmune thrombocytopenias. In: J Loscalzo AS, ed. Thrombosis and Hemorrhage. Philadelphia: JB Lippincott, 2003:441–56.
- Adner MM, Fisch GR, Starobin SG, Aster RH. Use of “compatible” platelet transfusions in treatment of congenital isoimmune thrombocytopenic purpura. N Engl J Med 1969;280:244–7.
- Kunicki TJ, Aster RH. Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann’s thrombasthenia. J Clin Invest 1978; 61:1225–31.
- Kunicki TJ, Aster RH. Isolation and immunologic characterization of the human platelet alloantigen, PlA1. Mol Immunol 1979;16:353–60.
- Newman PJ, Martin LS, Knipp MA, Kahn RA. Studies on the nature of the human platelet alloantigen, PlA1: localization to a 17,000-dalton polypeptide. Mol Immunol 1985;22:719–29.
- Fitzgerald LA, Steiner B, Rall SC Jr, Lo SS, Phillips DR. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin.” J Biol Chem 1987;262:3936–9.
- Newman PJ, Kawai Y, Montgomery RR, Kunicki TJ. Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa. J Cell Biol 1986;103: 81–6.
- Giltay JC, Leeksma OC, von dem Borne AE, van Mourik JA. Alloantigenic composition of the endothelial vitronectin receptor. Blood 1988;72:230–3.
- Giltay JC, Brinkman HJ, von dem Borne AE, van Mourik JA. Expression of the alloantigen Zwa (or PlA1) on human vascular smooth muscle cells and foreskin fibroblasts: a study on normal individuals and a patient with Glanzmann’s thrombasthenia. Blood 1989;74:965–70.
- Newman PJ, Gorski J, White GC 2nd, Gidwitz S, Cretney CJ, Aster RH. Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. J Clin Invest 1988;82: 739–43.
- Newman PJ, Derbes RS, Aster RH. The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing. J Clin Invest 1989;83:1778–81.
- Goldberger A, Kolodziej M, Poncz M, Bennett JS, Newman PJ. Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes. Blood 1991;78:681–7.
- Lyman S, Aster RH, Visentin GP, Newman PJ. Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system. Blood 1990;75:2343–8.
- Wang R, Furihata K, McFarland JG, Friedman K, Aster RH, Newman PJ. An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system. J Clin Invest 1992;90:2038–43.
- Santoso S, Kalb R, Walka M, Kiefel V, Mueller-Eckhardt C, Newman PJ. The human platelet alloantigens Br(a) and Br(b) are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2). J Clin Invest 1993; 92:2427–32.
- McFarland JG, Aster RH, Bussel JB, Gianopoulos JG, Derbes RS, Newman PJ. Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele-specific oligonucleotide probes. Blood 1991; 78:2276–82.
- Skogen B, Bellissimo DB, Hessner MJ, et al. Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers. Transfusion 1994;34:955–60.
- Calvete JJ, Henschen A, Gonzalez-Rodriguez J. Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family. Biochem J 1991;274(Pt 1):63–71.
- Flug F, Espinola R, Liu LX, et al. A 13-mer peptide straddling the leucine33/proline33 polymorphism in glycoprotein IIIa does not define the PLA1 epitope. Blood 1991;77:1964–9.
- Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 2004;432:59–67.
- Valentin N, Visentin GP, Newman PJ. Involvement of the cysteine-rich domain of glycoprotein IIIa in the expression of the human platelet alloantigen, PlA1: evidence for heterogeneity in the humoral response. Blood 1995;85:3028–33.
- Reznikoff-Etievant MF, Muller JY, Julien F, Patereau C. An immune response gene linked to MHC in man. Tissue Antigens 1983;22:312–4.
- Mueller-Eckhardt C, Mueller-Eckhardt G, Willen-Ohff H, et al. Immunogenicity of and immune response to the human platelet antigen Zwa is strongly associated with HLA-B8 and DR3. Tissue Antigens 1985;26:71–6.
- Valentin N, Vergracht A, Bignon JD, et al. HLA-DRw52a is involved in alloimmunization against PL-A1 antigen. Hum Immunol 1990;27:73–9.
- L’Abbe D, Tremblay L, Goldman M, Decary F, Chartrand P. Alloimmunization to platelet antigen HPA-1a (Zwa): association with HLA-DRw52a is not 100%. Transfus Med 1992;2:251.
- Maslanka K, Yassai M, Gorski J. Molecular identification of T cells that respond in a primary bulk culture to a peptide derived from a platelet glycoprotein implicated in neonatal alloimmune thrombocytopenia. J Clin Invest 1996;98:1802–8.
- Kuijpers RW, von dem Borne AE, Kiefel V, et al. Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PlA1) and HPA-1b (Zwb/PlA2). Hum Immunol 1992;34:253–6.
- Wu S, Maslanka K, Gorski J. An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding: a model for unidirectional alloimmune responses. J Immunol 1997;158: 3221–6.
- Weiss EJ, Bray PF, Tayback M, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996;334:1090–4.
- Vijayan KV, Liu Y, Souza S, Thiagarajan P, Bray PF. Fibrinogen and prothrombin binding is enhanced to the Pro33 isoform of purified integrin alphaIIbbeta3. J Thromb Haemost 2006;4:905–6.
- Bennett JS, Catella-Lawson F, Rut AR, et al. Effect of the Pl(A2) alloantigen on the function of beta(3)-integrins in platelets. Blood 2001;97:3093–9.
- Meiklejohn DJ, Urbaniak SJ, Greaves M. Platelet glycoprotein IIIa polymorphism HPA 1b (PlA2): no association with platelet fibrinogen binding. Br J Haematol 1999;105:664–6.
- Gardemann A, Humme J, Stricker J, et al. Association of the platelet glycoprotein IIIa PlA1/A2 gene polymorphism to coronary artery disease but not to nonfatal myocardial infarction in low risk patients. Thromb Haemost 1998;80: 214–7.
- Salido E, Martin B, Barrios Y, et al. The PlA2 polymorphism of the platelet glycoprotein IIIA gene as a risk factor for acute renal allograft rejection. J Am Soc Nephrol 1999;10:2599–605.
- Ridker PM, Hennekens CH, Schmitz C, Stampfer MJ, Lindpaintner K. PlA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet 1997;349:385–8.
- Feng D, Lindpaintner K, Larson MG, et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1999;19:1142–7.
- Lasne D, Krenn M, Pingault V, et al. Interdonor variability of platelet response to thrombin receptor activation: influence of PlA2 polymorphism. Br J Haematol 1997;99:801–7.
- Vijayan KV, Liu Y, Dong JF, Bray PF. Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. J Biol Chem 2003;278:3860–7.
- Vijayan KV, Liu Y, Sun W, Ito M, Bray PF. The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases. J Biol Chem 2005;280:21756–62.
DOI: https://doi.org/10.21307/immunohematology-2019-311 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 2 - 8
Published on: Apr 1, 2020
Published by: American National Red Cross
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Related subjects:
© 2020 R.H Aster, P.J. Newman, published by American National Red Cross
This work is licensed under the Creative Commons License.