Overt immediate hemolytic transfusion reaction attributable to anti-Wra

F.N. Boctor

doi:10.21307/immunohematology-2019-282

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Overt immediate hemolytic transfusion reaction attributable to anti-Wra

Immunohematology

Volume 24 (2008): Issue 3 (September 2008)

By: F.N. Boctor

Paid access

|Mar 2020

Abstract

Wr^a is a low-prevalence antigen. Anti-Wr^a is a relatively common antibody present in approximately 1 in 100 healthy blood donors. Anti-Wr^a is reported to cause different degrees of hemolysis in transfusion and in HDN, ranging from benign to severe. This report describes an acute overt hemolytic transfusion reaction in a patient whose serum contained anti-Wr^a and who received a Wr(a+) RBC component. Immunohematology2008;24:113–115.

References

Holman CA. A new rare human blood-group antigen (Wr^a). Lancet 1953;2:119–20.10.1016/S0140-6736(53)90058-0
Search in Google Scholar Back to article
Issitt PD, Anstee DJ, eds. The Diego blood group system. In: Applied Blood Group Serology. 4th ed. Durham, NC; Montgomery Scientific Publications, 1999:581–607.
Search in Google Scholar Back to article
Zelinski T, Coghlan G, White L, Philipps S. The Diego blood group locus is located on chromosome 17q. Genomics 1993;17:665–6.10.1006/geno.1993.13877902326
Search in Google Scholar Back to article
Wallis JP, Hedley GP, Charlton D, Parker PC, Scott Y, Chapman CE. The incidence of anti-Wr^a and Wr^a antigen in blood donors and hospital patients. Transfus Med 1996;6:361–4.10.1111/j.1365-3148.1996.tb00096.x8981731
Search in Google Scholar Back to article
Arriaga F, Llopis F, de la Rubia J, Carpio N, Moscardo J, Marty ML. Incidence of Wr^a antigen and anti-Wr^a in a Spanish population. Transfusion 2005;45:1324–6.10.1111/j.1537-2995.2005.00196.x16078920
Search in Google Scholar Back to article
Arriaga F, Palau J, Lopez F, et al. Anti-Wr^a in newborn twins. Transfusion 1991;31:381–2.10.1046/j.1537-2995.1991.31491213311.x2021006
Search in Google Scholar Back to article
Lubenko A, Contreras M. The incidence of hemolytic disease of the newborn attributable to anti-Wr^a. Transfusion 1992;32:87–8.10.1046/j.1537-2995.1992.32192116442.x1731445
Search in Google Scholar Back to article
Drozda E. Anti-Wr(a) and mild hemolytic disease of the newborn. Transfusion 1991;31:783.10.1046/j.1537-2995.1991.31892023514.x1926328
Search in Google Scholar Back to article
Hoffmann JJ. Anti-Wr^a: to screen or not to screen? Transfusion 2007;47:948–9.10.1111/j.1537-2995.2007.01216.x17465965
Search in Google Scholar Back to article
Schonewille H, van Zijl A, Wijermans PW. The importance of antibodies against low-incidence RBC antigens in complete and abbreviated crossmatching. Transfusion 2003;43:939–44.10.1046/j.1537-2995.2003.t01-1-00435.x12823754
Search in Google Scholar Back to article
Garratty G. How concerned should we be about missing antibodies to low incidence antigens? Transfusion 2003;43:844–7.10.1046/j.1537-2995.2003.00492.x12823741
Search in Google Scholar Back to article
Cherian G, Search S, Thomas E, Poole J, Davies SV, Massey E. An acute haemolytic transfusion reaction caused by anti-Wr. Transfus Med 2007;17:312–4.10.1111/j.1365-3148.2007.00739.x17680958
Search in Google Scholar Back to article
Shulman IA. The risk of an overt hemolytic transfusion reaction following the use of an immediate spin crossmatch. Arch Pathol Lab Med 1990;114:412–4.
Search in Google Scholar Back to article