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Investigating the possibility of drug-dependent platelet antibodies

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Paid access
|Mar 2020

References

  1. van den Bemt PM, Meyboom RH, Egberts AC. Drug-induced immune thrombocytopenia. Drug Safety 2004;27:1243–52.10.2165/00002018-200427150-00007
  2. Kaufman DW, Kelly JP, Johannes CB, et al. Acute thrombocytopenic purpura in relation to the use of drugs. Blood 1993;82:2714–18.10.1182/blood.V82.9.2714.2714
  3. Visentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin N Am 2007;21:685–96,vi.10.1016/j.hoc.2007.06.005
  4. Bougie DW, Wilker PR, Aster RH. Patients with quinine-induced immune thrombocytopenia have both “drug-dependent” and “drug-specific” antibodies. Blood 2006;108:922–7.10.1182/blood-2006-01-009803
  5. Leach MF, AuBuchon JP. Coincidence of gentamycin induced drug-dependent platelet antibodies. Transfusion 1998;38:29S.
  6. Warkentin TE. Heparin-induced thrombocytopenia: diagnosis and management. Circulation 2004;110:e454-8.10.1161/01.CIR.0000147537.72829.1B
  7. Lau LG, Chng WJ, Liu TC. Transfusion medicine illustrated: unnecessary transfusions due to pseudothrombocytopenia. Transfusion 2004;44:801.10.1111/j.1537-2995.2004.04009.x
  8. Braester A. Pseudothrombocytopenia as a pitfall in the treatment of essential thrombocythemia. Eur J Haematol 2003;70:251–2.10.1034/j.1600-0609.2003.00033.x
  9. Aster RH. Can drugs cause autoimmune thrombocytopenic purpura? Seminar Hematol 2000;37:229–38.10.1053/shem.2000.8954
  10. Kenney B, Stack G. Drug-induced thrombocytopenia. Arch Pathol Lab Med 2009;133:309–14.10.5858/133.2.309
  11. Garratty G, Petz LD. Drug-induced immune hemolytic anemia. Am J Med 1975;58:398–407.10.1016/0002-9343(75)90606-3
  12. Christie DJ, Mullen PC, Aster RH. Fab-mediated binding of drug-dependent antibodies to platelets in quinidine- and quinine-induced thrombocytopenia. J Clin Invest 1985;75:310–14.10.1172/JCI111691
  13. Smith ME, Reid DM, Jones CE, Jordan JV, Kautz CA, Shulman NR. Binding of quinine- and quinidine-dependent drug antibodies to platelets is mediated by the Fab domain of the immunoglobulin G and is not Fc dependent. J Clin Invest 1987;79:912–17.10.1172/JCI112901
  14. Mueller-Eckhardt C, Salama A. Drug-induced immune cytopenias: a unifying pathogenetic concept with special emphasis on the role of drug metabolites. Transf Med Rev 1990;4:69–77.10.1016/S0887-7963(90)70249-0
  15. Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med 2007;357:580–7.10.1056/NEJMra06646917687133
  16. Asvadi P, Ahmadi Z, Chong BH. Drug-induced thrombocytopenia: localization of the binding site of GPIX-specific quinine-dependent antibodies. Blood 2003;102:1670–7.10.1182/blood-2002-07-217512738668
  17. Aster RH. Immune thrombocytopenia caused by glycoproteinIIb/IIIa inhibitors.Chest2005;127(2Suppl):53S–9S.10.1378/chest.127.2_suppl.53S15706031
  18. Honda S, Tomiyama Y, Aoki T, et al. Association between ligand-induced conformational changes of integrin IIbbeta3 and IIbbeta3-mediated intracellular Ca2+ signaling. Blood 1998;92:3675–83.10.1182/blood.V92.10.3675
  19. Bougie DW, Wilker PR, Wuitschick ED, et al. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Blood 2002;100:2071–6.10.1182/blood.V100.6.2071
  20. Curtis BR, Swyers J, Divgi A, McFarland JG, Aster RH. Thrombocytopenia after second exposure to abciximab is caused by antibodies that recognize abciximab-coated platelets. Blood 2002;99:2054–9.10.1182/blood.V99.6.205411877279
  21. Von Drygalski A, Curtis BR, Bougie DW, et al. Vancomycin-induced immune thrombocytopenia. N Engl J Med 2007;356:904–10.10.1056/NEJMoa06506617329697
  22. Grossjohann B, Eichler P, Greinacher A, Santoso S, Kroll H. Ceftriaxone causes drug-induced immune thrombocytopenia and hemolytic anemia: characterization of targets on platelets and red blood cells. Transfusion 2004;44:1033–40.10.1111/j.1537-2995.2004.03378.x15225244
  23. Leach MF, Cooper LK, AuBuchon JP. Detection of drug-dependent, platelet-reactive antibodies by solid-phase red cell adherence assays. Br J Haematol 1997;97:755–61.10.1046/j.1365-2141.1997.1472960.x9217173
  24. Leach MF, Cooper LK, AuBuchon JP. Detection of drug-dependent antibodies by use of solid-phase red cell adherence techniques. Immunohematology 1995;11:143–9.10.21307/immunohematology-2019-806
  25. Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994;93:81–8.10.1172/JCI1169872937378282825
  26. Greinacher A, Kohlmann T, Strobel U, Sheppard JA, Warkentin TE. The temporal profile of the anti-PF4/heparin immune response. Blood 2009;113:4970–6.10.1182/blood-2008-08-17306219109231
  27. Christie DJ, Weber RW, Mullen PC, Cook JM, Aster RH. Structural features of the quinidine and quinine molecules necessary for binding of drug-induced antibodies to human platelets. J Lab Clin Med 1984;104:730–40.
  28. Leach MF, AuBuchon JP, Szczepiorkowski ZM. The incidence of positive direct antiglobulin tests and red cell drug antibodies in patients with drug-induced thrombocytopenia. Transfusion 2005;45:134A.
DOI: https://doi.org/10.21307/immunohematology-2019-246 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 136 - 140
Published on: Mar 20, 2020
Published by: American National Red Cross
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year

© 2020 J.P. AuBuchon, M.F. Leach, published by American National Red Cross
This work is licensed under the Creative Commons License.